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View Structure Prediction Details

Protein: YOS9
Organism: Saccharomyces cerevisiae
Length: 542 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YOS9.

Description E-value Query
Range
Subject
Range
OS9_YEAST - Protein OS-9 homolog OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YOS9 PE=1 SV=1
YOS9 - ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-...
0.0 [1..542] [1..542]
OS9_ARATH - Protein OS-9 homolog OS=Arabidopsis thaliana GN=OS9 PE=1 SV=1
7.0E-66 [49..269] [49..266]
CG6766-PA - This gene is referred to in FlyBase by the symbol Dmel\CG6766 (CG6766, FBgn0032398). It is a protein...
4.0E-59 [18..260] [1..251]
gi|123984679, gi... - gi|123998678|gb|ABM86982.1| amplified in osteosarcoma [synthetic construct], gi|123984679|gb|ABM8368...
gi|39644954, gi|... - gi|63252866|ref|NP_001017956.1| osteosarcoma amplified 9 isoform 2 precursor [Homo sapiens], gi|3964...
3.0E-55 [56..259] [56..247]
gi|13905114 - gi|13905114|gb|AAH06844.1| Os9 protein [Mus musculus]
4.0E-52 [56..259] [10..201]
gi|19113877 - gi|19113877|ref|NP_592965.1| hypothetical protein SPAC227.11c [Schizosaccharomyces pombe 972h-]
SPAC227.11c - sensor for misfolded ER glycoproteins Yos9
1.0E-49 [72..272] [83..278]

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Predicted Domain #1
Region A:
Residues: [1-265]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQAKIIYALS AISALIPLGS SLLAPIEDPI VSNKYLISYI DEDDWSDRIL QNQSVMNSGY  60
   61 IVNMGDDLEC FIQNASTQLN DVLEDSNEHS NSEKTALLTK TLNQGVKTIF DKLNERCIFY 120
  121 QAGFWIYEYC PGIEFVQFHG RVNTKTGEIV NRDESLVYRL GKPKANVEER EFELLYDDVG 180
  181 YYISEIIGSG DICDVTGAER MVEIQYVCGG SNSGPSTIQW VRETKICVYE AQVTIPELCN 240
  241 LELLAKNEDQ KNASPILCRM PAKSK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [266-542]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IGSNSIDLIT KYEPIFLGSG IYFLRPFNTD ERDKLMVTDN AMSNWDEITE TYYQKFGNAI  60
   61 NKMLSLRLVS LPNGHILQPG DSCVWLAEVV DMKDRFQTTL SLNILNSQRA EIFFNKTFTF 120
  121 NEDNGNFLSY KIGDHGESTE LGQITHSNKA DINTAEIRSD EYLINTDNEL FLRISKEIAE 180
  181 VKELLNEIVS PHEMEVIFEN MRNQPNNDFE LALMNKLKSS LNDDNKVEQI NNARMDDDES 240
  241 TSHTTRDIGE AGSQTTGNTE SEVTNVAAGV FIEHDEL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.16931544864195 bayes_pls_golite062009
receptor activity 0.66788201077791 bayes_pls_golite062009
catalytic activity 0.282237710666423 bayes_pls_golite062009
transmembrane receptor activity 0.272927118711356 bayes_pls_golite062009
signal transducer activity 0.26239044372713 bayes_pls_golite062009
molecular transducer activity 0.26239044372713 bayes_pls_golite062009
protein binding 0.192633833830859 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.0376900612956657 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [241-414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LELLAKNEDQ KNASPILCRM PAKSKIGSNS IDLITKYEPI FLGSGIYFLR PFNTDERDKL  60
   61 MVTDNAMSNW DEITETYYQK FGNAINKMLS LRLVSLPNGH ILQPGDSCVW LAEVVDMKDR 120
  121 FQTTLSLNIL NSQRAEIFFN KTFTFNEDNG NFLSYKIGDH GESTELGQIT HSNK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [415-542]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADINTAEIRS DEYLINTDNE LFLRISKEIA EVKELLNEIV SPHEMEVIFE NMRNQPNNDF  60
   61 ELALMNKLKS SLNDDNKVEQ INNARMDDDE STSHTTRDIG EAGSQTTGNT ESEVTNVAAG 120
  121 VFIEHDEL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle