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Protein Overview: GCS1

General Information:
Name(s) found: GCS1 / YDL226C [SGD]
Description(s) found:
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  • gi|6319975|ref|NP_010055.1| ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p; Gcs1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|462172|sp|P35197.1|GCS1_YEAST RecName: Full=ADP-ribosylation factor GTPase-activating protein GCS1 [NCBI NR]
  • gi|408803|gb|AAA50389.1| zinc finger protein [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1431381|emb|CAA98805.1| GCS1 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S47006 zinc finger protein GCS1 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • ADP-ribosylation factor GTPase-activating protein GCS1 OS=Saccharomyces cerevisiae GN=GCS1 PE=1 SV=1 [Swiss-Prot]
  • GCS1 ADP-ribosylation factor GTPase-activating protein (ARF-GAP) [mips]
  • ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p [SGD]
  • GCS1, Chr IV from 51116-52174, reverse complement [yeast_orfs2]
  • Chr IV from 51116-52174, reverse complement [yeastorf3.fasta]
  • Chr IV from 52174-51116, reverse complement [yeastorf5.fasta]
  • (P35197) ADP-ribosylation factor GTPase-activating protein GCS1 [4932.FASTACCERV.txt]
  • GCS1 SGDID:S0002385, Chr IV from 52174-51116, reverse complement, Verified ORF [yeastflysequest.fasta]
  • ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p [Saccharomyces cerevisiae]gi|1431381|emb|CAA98805.1| GCS1 [Saccharomyces cerevisiae]gi|1078607|pir||S47006 zinc finger p [nrdb_11152004_Chlamydomonas]
  • GCS1 SGDID:S000002385, Chr IV from 52174-51116, reverse complement, Verified ORF, "ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • GCS1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p; Gcs1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • zinc finger protein [nr-271106-contam.fasta]
  • ADP-ribosylation factor GTPase-activating protein GCS1 [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • ADP-ribosylation factor GTPase-activating protein GCS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GCS1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GCS1 SGDID:S000002385, Chr IV from 52173-51115, Genome Release 64-1-1, reverse complement, Verified ORF, "ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p" [yeast-030211-contam.fasta]
  • GCS1 SGDID:S000002385, Chr IV from 52173-51115, Genome Release 64-2-1, reverse complement, Verified ORF, "ADP-ribosylation factor GTPase activating protein (ARF GAP); involved in ER-Golgi transport; required for prospore membrane formation; regulates phospholipase Spo14p; shares functional similarity with Glo3p; GCS1 has a paralog, SPS18, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YDL226C SGDID:S000002385, Chr IV from 52173-51115, Genome Release 64-1-1, reverse complement, Verified ORF, "ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 352 amino acids

    Gene Ontology:
    Cellular Component: trans-Golgi network [IDALink to PubMed article]
    endosome [IDALink to PubMed article]
    cytoskeleton [IMPLink to PubMed article][IPILink to PubMed article]
    ER-Golgi intermediate compartment [IPILink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IGILink to PubMed article][IMPLink to PubMed article]
    retrograde vesicle-mediated transport, Golgi to ER [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed article]
    Golgi to plasma membrane protein transport [IMPLink to PubMed article]
    actin filament reorganization involved in cell cycle [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: ARF GTPase activator activity [IDALink to PubMed article][ISSLink to PubMed article]
    actin binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDWKVDPDT RRRLLQLQKI GANKKCMDCG APNPQWATPK FGAFICLECA GIHRGLGVHI  60
   61 SFVRSITMDQ FKPEELLRME KGGNEPLTEW FKSHNIDLSL PQKVKYDNPV AEDYKEKLTC 120
  121 LCEDRVFEER EHLDFDASKL SATSQTAASA TPGVAQSREG TPLENRRSAT PANSSNGANF 180
  181 QKEKNEAYFA ELGKKNQSRP DHLPPSQGGK YQGFGSTPAK PPQERSAGSS NTLSLENFQA 240
  241 DPLGTLSRGW GLFSSAVTKS FEDVNETVIK PHVQQWQSGE LSEETKRAAA QFGQKFQETS 300
  301 SYGFQAFSNF TKNFNGNAED SSTAGNTTHT EYQKIDNNDK KNEQDEDKWD DF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GCS1 GLO3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GCS1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..201] PSI-BLAST 187.221849 Pyk2-associated protein beta; Pyk2-associated protein beta ARF-GAP domain
    2 View Details [202..254] deduced N/A No confident structure predictions are available.
    3 View Details [255..352] MSA 3.023988 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle