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Protein Overview: ECM31

General Information:
Name(s) found: ECM31 / YBR176W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 312 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    Biological Process: pantothenate biosynthetic process [IMPLink to PubMed article]
    Molecular Function: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIMKRQLCT SSKRFFSTAK NVVKYNTIQD IRNKYFTGTP LSMCTAYDFI TATWVNKANC  60
   61 DLLLVGDSLA MTSLGYDSTI TLSLNEFKYH VASVCRAEGS SMVVVDMPFG TFESGISDGL 120
  121 KNAIDIMKLD SKVTSVKVEV GSYTKDKYAM KFIEELCSRG IPVMAHIGLT PQKVHSLGGY 180
  181 KVQGSKSLLQ MQELYETAMQ LQKIGCWSIL IECVPHKMAQ FITSKLSVPT IGIGAGNGTS 240
  241 GQVLVISDLL GMQGDSVPKF VKQAVNMTDI ATQGLKEYIA SVEDRTFPER GTHTFKVKED 300
  301 LWNEFLSSIN EK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARL3 CDC123 ECM31 PHO13 TEF1, TEF2 THP1 YIH1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #21 Asynchronous Prep2-IMAC Phosphopeptide enrichment A1 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ECM31 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..312] ORFEUS 8.63 Trp synthase alpha-subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
    		•  4.08693637310631 bayes_pls_golite062009
  • catalytic activity
    		•  2.59838799615646 bayes_pls_golite062009
  • hydroxymethyl-, formyl- and related transferase activity
    		•  2.05689968523792 bayes_pls_golite062009
  • transferase activity
    		•  1.07154136609184 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.646649320021871 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.366715189574293 bayes_pls_golite062009
  • oxo-acid-lyase activity
    		•  0.0960362356555544 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.0846611486307003 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle