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Protein Overview: FBpp0310590

General Information:
Name(s) found: FBpp0310590 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • type=protein; loc=2R:join(19553144..19553410,19553474..19553558,19559499..19559611,19561809..19561865,19561937..19562142,19562327..19562386,19562454..19562508,19562630..19562728,19562878..19562988,19563062..19563231,19563301..19563511,19564571..19564711,19564772..19564870,19564928..19565176,19565238..19565460,19565525..19565682,19565741..19566011,19566070..19566212); ID=FBpp0310590; name=Pde8-PE; parent=FBgn0266377,FBtr0344178; dbxref=FlyBase:FBpp0310590,FlyBase_Annotation_IDs:CG45019-PE; MD5=b966a9dd995e92f38fce075874bf33b3; length=905; release=r5.56; species=Dmel; [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 905 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: two-component signal transduction system (phosphorelay) [IEA]
    mesoderm development [IEP]
    regulation of transcription, DNA-dependent [IEA]
    Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity [IDA][ISS]
    two-component response regulator activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCSPSTLPP APSAGQTGER GSLPLDASEK DESRLFCIKL RRSRLRRCSC GGVTLQPPSD  60
   61 GNGSTAGDNL CGQVLLNPLQ TKSEADYEKL STGKKDSIVT VAALGNFTHS VVRRATGSTG 120
  121 TSGTSSSGGN SRPGHRKSSL ALALTPEDEP MDVYQRNLMD LKYPTVLPPN PPLKALLVFH 180
  181 KSDSICEAIT AACQRHQLDV TLVKSKEEAL DTLQKSYATA QCYHLIIIDA RSSKNLDAEH 240
  241 IARTIRHTHG HHLTTIIAVC KKSFFEKDDV LIALLDAGVN RCVAETTNLA MCSVELKQIL 300
  301 HSIIRPHNVM STQQALYTAL HRLKEVVLIT DDLLRIQYAN RATERLLNMR LDEIISKQLE 360
  361 DIFVSDLSTI SEQCKNIKEF DGILTVRRKS QEGIPMHVRV VPVACIGSAP THLIFNFDVP 420
  421 GGQMDFIATL PQPKEAPRGS LHSVRRCSFD VRSIASDGLR RTSLAKLTSL PLEAPITKEN 480
  481 CSADEARLID KVLEFLKREG LYSPQMKEIR TDDPIATDLI GALLTGPSVY SSRRSSNDSI 540
  541 IRTGSSTRTA AIVPAKMKSN PIIMELLDES LSWDFDIFKL EEITDYHPLL YLGMEMFRRF 600
  601 DVFATLNIDE NVCKAWLAVI EAHYRKSNTY HNSTHAADVM QATGAFITQL TNKDMLVMDR 660
  661 MEEATALIAA AAHDVDHPGR SSAFLCNSND ALAVLYNDLT VLENHHAAIT FKLTLGDDKI 720
  721 NIFKNLDKET YKSARSTIID MILATEMTRH FEHLAKFVSV FGGEEPRDHN PQTDEETSIL 780
  781 MRRMLIKVAD VSNPARPMQF CIEWARRIAE EYFMQTDEEK QRHLPIVMPM FDRATCSIPK 840
  841 SQIGFIEYII QDMMHAWESF IDMPQLITYM QINYSQWKKY DEQGVNTLAE IMAKQPPVGK 900
  901 MANSK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..149] PSI-BLAST 24.30103 Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
    2 View Details [150..391] PSI-BLAST 7.69897 PhoB; PhoB receiver domain
    3 View Details [392..555] FFAS03 2.38 Response regulator PleD in complex with c-diGMP
    4 View Details [556..905] PSI-BLAST 108.0 Catalytic domain of cyclic nucleotide phosphodiesterase pde4d

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • signal transducer activity
    		•  6.27803885496668 bayes_pls_golite062009
  • molecular transducer activity
    		•  6.27803885496668 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.41399633914211 bayes_pls_golite062009
  • two-component response regulator activity
    		•  3.34935030645912 bayes_pls_golite062009
  • DNA binding
    		•  2.40455942568472 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.27397473548288 bayes_pls_golite062009
  • binding
    		•  2.13456601528542 bayes_pls_golite062009
  • transcription factor activity
    		•  1.64787246557234 bayes_pls_golite062009
  • protein kinase activity
    		•  0.609719108152158 bayes_pls_golite062009
  • receptor activity
    		•  0.348089236254884 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  0.200362612626285 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0408032640298051 bayes_pls_golite062009
    3
    Term Confidence Notes
  • cyclase activity
    		•  4.05299211940818 bayes_pls_golite062009
  • phosphorus-oxygen lyase activity
    		•  3.70607617943807 bayes_pls_golite062009
  • signal transducer activity
    		•  3.23554823331362 bayes_pls_golite062009
  • molecular transducer activity
    		•  3.23554823331362 bayes_pls_golite062009
  • adenylate cyclase activity
    		•  3.13811436727886 bayes_pls_golite062009
  • guanylate cyclase activity
    		•  2.04284145414009 bayes_pls_golite062009
  • binding
    		•  0.713617732247444 bayes_pls_golite062009
  • receptor activity
    		•  0.562829609915074 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0406741669345618 bayes_pls_golite062009
    4
    Term Confidence Notes
  • 3',5'-cyclic-nucleotide phosphodiesterase activity
    		•  4.72905094107626 bayes_pls_golite062009
  • cyclic-nucleotide phosphodiesterase activity
    		•  4.61245226349897 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  3.65984874547256 bayes_pls_golite062009
  • 3',5'-cyclic-AMP phosphodiesterase activity
    		•  3.3591603098704 bayes_pls_golite062009
  • 3',5'-cyclic-GMP phosphodiesterase activity
    		•  2.96981753811593 bayes_pls_golite062009
  • hydrolase activity
    		•  1.22736412056595 bayes_pls_golite062009
  • catalytic activity
    		•  1.07048165010262 bayes_pls_golite062009
  • binding
    		•  0.994379083280533 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.511207383357891 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.432240759268351 bayes_pls_golite062009
  • protein binding
    		•  0.162314119157812 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle