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View Structure Prediction Details

Protein: FBpp0310590
Organism: Drosophila melanogaster
Length: 905 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FBpp0310590.

Description E-value Query
Range
Subject
Range
FBpp0310595, FBp... - type=protein; loc=2R:join(19553144..19553410,19553474..19553558,19559499..19559611,19561809..1956186...
566.0 [0..1] [905..1]

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Predicted Domain #1
Region A:
Residues: [1-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGCSPSTLPP APSAGQTGER GSLPLDASEK DESRLFCIKL RRSRLRRCSC GGVTLQPPSD  60
   61 GNGSTAGDNL CGQVLLNPLQ TKSEADYEKL STGKKDSIVT VAALGNFTHS VVRRATGSTG 120
  121 TSGTSSSGGN SRPGHRKSSL ALALTPEDE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.30103
Match: 2c2aA
Description: Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [150-391]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PMDVYQRNLM DLKYPTVLPP NPPLKALLVF HKSDSICEAI TAACQRHQLD VTLVKSKEEA  60
   61 LDTLQKSYAT AQCYHLIIID ARSSKNLDAE HIARTIRHTH GHHLTTIIAV CKKSFFEKDD 120
  121 VLIALLDAGV NRCVAETTNL AMCSVELKQI LHSIIRPHNV MSTQQALYTA LHRLKEVVLI 180
  181 TDDLLRIQYA NRATERLLNM RLDEIISKQL EDIFVSDLST ISEQCKNIKE FDGILTVRRK 240
  241 SQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 7.69897
Match: 1kgsA
Description: PhoB; PhoB receiver domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
signal transducer activity 6.27803885496668 bayes_pls_golite062009
molecular transducer activity 6.27803885496668 bayes_pls_golite062009
transcription regulator activity 4.41399633914211 bayes_pls_golite062009
two-component response regulator activity 3.34935030645912 bayes_pls_golite062009
DNA binding 2.40455942568472 bayes_pls_golite062009
nucleic acid binding 2.27397473548288 bayes_pls_golite062009
binding 2.13456601528542 bayes_pls_golite062009
transcription factor activity 1.64787246557234 bayes_pls_golite062009
protein kinase activity 0.609719108152158 bayes_pls_golite062009
receptor activity 0.348089236254884 bayes_pls_golite062009
transmembrane receptor activity 0.200362612626285 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0408032640298051 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [392-555]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGIPMHVRVV PVACIGSAPT HLIFNFDVPG GQMDFIATLP QPKEAPRGSL HSVRRCSFDV  60
   61 RSIASDGLRR TSLAKLTSLP LEAPITKENC SADEARLIDK VLEFLKREGL YSPQMKEIRT 120
  121 DDPIATDLIG ALLTGPSVYS SRRSSNDSII RTGSSTRTAA IVPA

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.38
Match: 1w25A
Description: Response regulator PleD in complex with c-diGMP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclase activity 4.05299211940818 bayes_pls_golite062009
phosphorus-oxygen lyase activity 3.70607617943807 bayes_pls_golite062009
signal transducer activity 3.23554823331362 bayes_pls_golite062009
molecular transducer activity 3.23554823331362 bayes_pls_golite062009
adenylate cyclase activity 3.13811436727886 bayes_pls_golite062009
guanylate cyclase activity 2.04284145414009 bayes_pls_golite062009
binding 0.713617732247444 bayes_pls_golite062009
receptor activity 0.562829609915074 bayes_pls_golite062009
transcription regulator activity 0.0406741669345618 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [556-905]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KMKSNPIIME LLDESLSWDF DIFKLEEITD YHPLLYLGME MFRRFDVFAT LNIDENVCKA  60
   61 WLAVIEAHYR KSNTYHNSTH AADVMQATGA FITQLTNKDM LVMDRMEEAT ALIAAAAHDV 120
  121 DHPGRSSAFL CNSNDALAVL YNDLTVLENH HAAITFKLTL GDDKINIFKN LDKETYKSAR 180
  181 STIIDMILAT EMTRHFEHLA KFVSVFGGEE PRDHNPQTDE ETSILMRRML IKVADVSNPA 240
  241 RPMQFCIEWA RRIAEEYFMQ TDEEKQRHLP IVMPMFDRAT CSIPKSQIGF IEYIIQDMMH 300
  301 AWESFIDMPQ LITYMQINYS QWKKYDEQGV NTLAEIMAKQ PPVGKMANSK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 108.0
Match: 1oynA
Description: Catalytic domain of cyclic nucleotide phosphodiesterase pde4d
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
3',5'-cyclic-nucleotide phosphodiesterase activity 4.72905094107626 bayes_pls_golite062009
cyclic-nucleotide phosphodiesterase activity 4.61245226349897 bayes_pls_golite062009
phosphoric diester hydrolase activity 3.65984874547256 bayes_pls_golite062009
3',5'-cyclic-AMP phosphodiesterase activity 3.3591603098704 bayes_pls_golite062009
3',5'-cyclic-GMP phosphodiesterase activity 2.96981753811593 bayes_pls_golite062009
hydrolase activity 1.22736412056595 bayes_pls_golite062009
catalytic activity 1.07048165010262 bayes_pls_golite062009
binding 0.994379083280533 bayes_pls_golite062009
phosphoric ester hydrolase activity 0.511207383357891 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.432240759268351 bayes_pls_golite062009
protein binding 0.162314119157812 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle