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View Structure Prediction Details

Protein: LBX1_MOUSE
Organism: Mus musculus
Length: 282 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LBX1_MOUSE.

Description E-value Query
Range
Subject
Range
gi|786328 - gi|786328|gb|AAB32671.1| Pax-6 [Rattus sp.]
gi|480038, gi|446399 - gi|480038|pir||S36166 paired box transcription factor Pax-6 - rat (fragment), gi|446399|prf||1911405...
137.0 [0..33] [203..25]
gi|2696969 - gi|2696969|dbj|BAA24022.1| PAX6 LS [Cynops pyrrhogaster]
132.0 [0..33] [257..149]
LBX1 - ladybird homeobox 1
131.0 [0..1] [270..1]
gi|55634463 - gi|55634463|ref|XP_521589.1| PREDICTED: transcription factor LBX1 [Pan troglodytes]
131.0 [0..1] [270..1]
gi|57107543 - gi|57107543|ref|XP_543979.1| PREDICTED: similar to transcription factor LBX1 [Canis familiaris]
130.0 [0..1] [270..1]
gi|109090317 - gi|109090317|ref|XP_001109952.1| PREDICTED: similar to transcription factor LBX1 [Macaca mulatta]
130.0 [0..1] [270..1]
gi|3402201 - gi|3402201|emb|CAA16493.1| PAX6 [Takifugu rubripes]
130.0 [0..33] [280..138]
gi|5758937 - gi|5758937|gb|AAD50902.1|AF169413_1 paired-box transcription factor +- isoform [Ambystoma mexicanum]
129.0 [0..33] [257..130]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS YSLCGAAHLL  60
   61 AAADKHAPGG LPLAGRALLS QTSPLCALEE LASKTFKGLE VSVLQAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [108-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGRDGMTIFG QRQTPKKRRK SRTAFTNHQI YELEKRFLYQ KYLSPADRDQ IAQQLGLTNA  60
   61 QVITWFQNRR AKLKRDLEEM KA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 1pufA
Description: Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
serum response element binding 0.32349914936049 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [190-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVESAKKLGP SGQMDIVALA ELEQNSEASG GGGGGGCGRA KSRPGSPALP PGAPQAPGGG  60
   61 PLQLSPASPL TDQRASSQDC SEDEEDEEID VDD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle