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View Structure Prediction Details

Protein: LBX1_MOUSE
Organism: Mus musculus
Length: 282 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LBX1_MOUSE.

Description E-value Query
Range
Subject
Range
gi|786328 - gi|786328|gb|AAB32671.1| Pax-6 [Rattus sp.]
gi|480038, gi|446399 - gi|480038|pir||S36166 paired box transcription factor Pax-6 - rat (fragment), gi|446399|prf||1911405...
137.0 [0..33] [203..25]
gi|2696969 - gi|2696969|dbj|BAA24022.1| PAX6 LS [Cynops pyrrhogaster]
132.0 [0..33] [257..149]
LBX1 - ladybird homeobox 1
131.0 [0..1] [270..1]
gi|55634463 - gi|55634463|ref|XP_521589.1| PREDICTED: transcription factor LBX1 [Pan troglodytes]
131.0 [0..1] [270..1]
gi|57107543 - gi|57107543|ref|XP_543979.1| PREDICTED: similar to transcription factor LBX1 [Canis familiaris]
130.0 [0..1] [270..1]
gi|109090317 - gi|109090317|ref|XP_001109952.1| PREDICTED: similar to transcription factor LBX1 [Macaca mulatta]
130.0 [0..1] [270..1]
gi|3402201 - gi|3402201|emb|CAA16493.1| PAX6 [Takifugu rubripes]
130.0 [0..33] [280..138]
gi|5758937 - gi|5758937|gb|AAD50902.1|AF169413_1 paired-box transcription factor +- isoform [Ambystoma mexicanum]
129.0 [0..33] [257..130]

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Predicted Domain #1
Region A:
Residues: [1-107]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSKEDGKAA PGEERRRSPL DHLPPPANSN KPLTPFSIED ILNKPSVRRS YSLCGAAHLL  60
   61 AAADKHAPGG LPLAGRALLS QTSPLCALEE LASKTFKGLE VSVLQAA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [108-189]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGRDGMTIFG QRQTPKKRRK SRTAFTNHQI YELEKRFLYQ KYLSPADRDQ IAQQLGLTNA  60
   61 QVITWFQNRR AKLKRDLEEM KA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 24.69897
Match: 1pufA
Description: Crystal Structure of HoxA9 and Pbx1 homeodomains bound to DNA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.51452285155271 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
RNA polymerase II transcription factor activity 3.16896789933192 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.73068440195944 bayes_pls_golite062009
chromatin binding 1.68956710349366 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.62096064323298 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
serum response element binding 0.32349914936049 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [190-282]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DVESAKKLGP SGQMDIVALA ELEQNSEASG GGGGGGCGRA KSRPGSPALP PGAPQAPGGG  60
   61 PLQLSPASPL TDQRASSQDC SEDEEDEEID VDD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle