YRC Public Data Repository - Protein Structure Prediction

Protein:	YGHZ_ECOLI
Organism:	Escherichia coli
Length:	346 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YGHZ_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|159184800, gi... - gi\|17935423\|ref\|NP_532213.1\| hypothetical protein Atu1524 [Agrobacterium tumefaciens str. C58], gi\|1... gi\|25316302 - pir\|\|AC2764 conserved hypothetical protein Atu1524 [imported] - Agrobacterium tumefaciens (strain C5...	365.0	[0..1]	[346..1]
gi\|26249568, gi\|... - gi\|26249568\|ref\|NP_755608.1\| aldo-keto reductase [Escherichia coli CFT073], gi\|26109976\|gb\|AAN82181.... gi\|218691292, gi... - gi\|218691292\|ref\|YP_002399504.1\| aldo-keto reductase [Escherichia coli ED1a], gi\|218428856\|emb\|CAR09... gi\|227887707, gi... - gi\|227887707\|ref\|ZP_04005512.1\| aldo-keto reductase [Escherichia coli 83972], gi\|227835103\|gb\|EEJ455...	360.0	[0..1]	[346..1]
gi\|75515202, gi\|... - gi\|75515202\|ref\|ZP_00737386.1\| COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydroge... gi\|194431726, gi... - gi\|194431726\|ref\|ZP_03064017.1\| oxidoreductase, aldo/keto reductase family [Shigella dysenteriae 101...	360.0	[0..1]	[346..1]
gi\|191172493, gi... - gi\|75240544\|ref\|ZP_00724472.1\| COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydroge...	360.0	[0..1]	[346..1]
gi\|13363357, gi\|... - gi\|15833139\|ref\|NP_311912.1\| aldo-keto reductase [Escherichia coli O157:H7 str. Sakai], gi\|13363357\|... gi\|208813978, gi... - gi\|208813978\|ref\|ZP_03255307.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7... gi\|254594357, gi... - gi\|254794957\|ref\|YP_003079794.1\| aldo-keto reductase [Escherichia coli O157:H7 str. TW14359], gi\|254... gi\|209399849, gi... - gi\|209399849\|ref\|YP_002272480.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H... gi\|217319477, gi... - gi\|217327110\|ref\|ZP_03443193.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7... gi\|168785870, gi... - gi\|189373785\|gb\|EDU92201.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7 str... gi\|209759770, gi... - pir\|\|E91114 probable reductase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 0509952... gi\|189379793, gi... - gi\|189379793\|gb\|EDU98209.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7 str... gi\|195937147 - gi\|195937147\|ref\|ZP_03082529.1\| aldo-keto reductase [Escherichia coli O157:H7 str. EC4024] gi\|208728041, gi... - gi\|208808240\|ref\|ZP_03250577.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7... gi\|168760156, gi... - gi\|189369235\|gb\|EDU87651.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7 str... gi\|168767019, gi... - gi\|189363673\|gb\|EDU82092.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7 str... gi\|187770824, gi... - gi\|187770824\|gb\|EDU34668.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7 str... gi\|189000568, gi... - gi\|189000568\|gb\|EDU69554.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7 str... gi\|188017914, gi... - gi\|188017914\|gb\|EDU56036.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7 str... GPR_ECO57 - L-glyceraldehyde 3-phosphate reductase OS=Escherichia coli O157:H7 GN=gpr PE=3 SV=1 gi\|189358453, gi... - gi\|189358453\|gb\|EDU76872.1\| oxidoreductase, aldo/keto reductase family [Escherichia coli O157:H7 str...	360.0	[0..1]	[346..1]
gi\|192959288, gi... - gi\|75239416\|ref\|ZP_00723387.1\| COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydroge... gi\|75187823, gi\|... - gi\|75187823\|ref\|ZP_00701090.1\| COG0667: Predicted oxidoreductases (related to aryl-alcohol dehydroge... gi\|24053466, gi\|... - gi\|24114308\|ref\|NP_708818.1\| aldo-keto reductase [Shigella flexneri 2a str. 301], gi\|24053466\|gb\|AAN... gi\|30064355, gi\|... - gi\|30064355\|ref\|NP_838526.1\| aldo-keto reductase [Shigella flexneri 2a str. 2457T], gi\|30042612\|gb\|A... gi\|110806903, gi... - gi\|110806903\|ref\|YP_690423.1\| aldo-keto reductase [Shigella flexneri 5 str. 8401], gi\|110616451\|gb\|A...	359.0	[0..1]	[346..1]
gi\|91073988, gi\|... - gi\|91212414\|ref\|YP_542400.1\| aldo-keto reductase [Escherichia coli UTI89], gi\|91073988\|gb\|ABE08869.1... gi\|226899292, gi... - gi\|237706252\|ref\|ZP_04536733.1\| aldo-keto reductase [Escherichia sp. 3_2_53FAA], gi\|226899292\|gb\|EEH... gi\|218560076, gi... - gi\|218560076\|ref\|YP_002392989.1\| aldo-keto reductase [Escherichia coli S88], gi\|218366845\|emb\|CAR046...	359.0	[0..1]	[346..1]
gi\|110643240, gi... - gi\|110643240\|ref\|YP_670970.1\| aldo-keto reductase [Escherichia coli 536], gi\|110344832\|gb\|ABG71069.1...	359.0	[0..1]	[346..1]
gi\|115514429, gi... - gi\|117625305\|ref\|YP_854506.1\| aldo-keto reductase [Escherichia coli APEC O1], gi\|115514429\|gb\|ABJ025...	359.0	[0..1]	[346..1]
gi\|74313545, gi\|... - gi\|74313545\|ref\|YP_311964.1\| aldo-keto reductase [Shigella sonnei Ss046], gi\|73857022\|gb\|AAZ89729.1\|...	359.0	[0..1]	[346..1]

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Predicted Domain #1

Region A:
Residues: [1-346]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVWLANPERY GQMQYRYCGK SGLRLPALSL GLWHNFGHVN ALESQRAILR KAFDLGITHF  60
   61 DLANNYGPPP GSAEENFGRL LREDFAAYRD ELIISTKAGY DMWPGPYGSG GSRKYLLASL 120
  121 DQSLKRMGLE YVDIFYSHRV DENTPMEETA SALAHAVQSG KALYVGISSY SPERTQKMVE 180
  181 LLREWKIPLL IHQPSYNLLN RWVDKSGLLD TLQNNGVGCI AFTPLAQGLL TGKYLNGIPQ 240
  241 DSRMHREGNK VRGLTPKMLT EANLNSLRLL NEMAQQRGQS MAQMALSWLL KDDRVTSVLI 300
  301 GASRAEQLEE NVQALNNLTF STKELAQIDQ HIADGELNLW QASSDK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	89.221849
Match:	1exbA
Description:	Voltage-dependent K+ channel beta subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
potassium channel activity	7.51963276589303	bayes_pls_golite062009
voltage-gated potassium channel activity	7.40239094355354	bayes_pls_golite062009
voltage-gated cation channel activity	6.67507110634301	bayes_pls_golite062009
metal ion transmembrane transporter activity	6.588881463055	bayes_pls_golite062009
voltage-gated ion channel activity	6.52286930358188	bayes_pls_golite062009
voltage-gated channel activity	6.50716590143831	bayes_pls_golite062009
cation channel activity	5.72172645555113	bayes_pls_golite062009
ion channel activity	5.15119282480682	bayes_pls_golite062009
passive transmembrane transporter activity	5.07214658557001	bayes_pls_golite062009
channel activity	5.07214658557001	bayes_pls_golite062009
substrate-specific channel activity	5.02503292701043	bayes_pls_golite062009
gated channel activity	4.92848832197692	bayes_pls_golite062009
pyridoxine 4-dehydrogenase activity	3.25535446462297	bayes_pls_golite062009
ion transmembrane transporter activity	2.63772951680109	bayes_pls_golite062009
cation transmembrane transporter activity	2.58068601897668	bayes_pls_golite062009
aldo-keto reductase activity	2.57303336304449	bayes_pls_golite062009
aryl-alcohol dehydrogenase activity	2.5168190536972	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.46488926936937	bayes_pls_golite062009
catalytic activity	1.68179794468736	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.48881830724998	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47641884930911	bayes_pls_golite062009
transporter activity	1.24767072239634	bayes_pls_golite062009
oxidoreductase activity	1.17915737521094	bayes_pls_golite062009
aldehyde reductase activity	1.16639404121425	bayes_pls_golite062009
binding	1.15657176144267	bayes_pls_golite062009
transmembrane transporter activity	1.03420335553507	bayes_pls_golite062009
potassium channel regulator activity	1.03017249802223	bayes_pls_golite062009
substrate-specific transporter activity	0.783004917746429	bayes_pls_golite062009
protein binding	0.220529867719707	bayes_pls_golite062009
3-alpha-hydroxysteroid dehydrogenase (B-specific) activity	0.207008954325429	bayes_pls_golite062009
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	0.207008954325429	bayes_pls_golite062009
	0.139676323362391	bayes_pls_golite062009
channel regulator activity	0.12154513851913	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: