YRC Public Data Repository - Protein Structure Prediction

Protein:	YFBQ_ECOLI
Organism:	Escherichia coli
Length:	405 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YFBQ_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|90440101, gi\|... - gi\|90579268\|ref\|ZP_01235078.1\| aspartate aminotransferase [Vibrio angustum S14], gi\|90440101\|gb\|EAS6...	377.0	[0..1]	[404..1]
gi\|89073240, gi\|... - gi\|89073240\|ref\|ZP_01159770.1\| aspartate aminotransferase [Photobacterium sp. SKA34], gi\|89050950\|gb...	376.0	[0..1]	[404..1]
gi\|113527019, gi... - gi\|113868243\|ref\|YP_726732.1\| aminotransferase AlaT [Ralstonia eutropha H16], gi\|113527019\|emb\|CAJ93...	372.0	[0..1]	[404..1]
AAT_AQUAE - Aspartate aminotransferase OS=Aquifex aeolicus (strain VF5) GN=aspC PE=3 SV=1 AAT_AQUAE - Aspartate aminotransferase OS=Aquifex aeolicus GN=aspC PE=3 SV=1	372.0	[0..6]	[401..5]
gi\|72119095, gi\|... - gi\|73541682\|ref\|YP_296202.1\| aminotransferase AlaT [Ralstonia eutropha JMP134], gi\|72119095\|gb\|AAZ61...	370.0	[0..2]	[404..18]
gi\|46914225, gi\|... - gi\|54309787\|ref\|YP_130807.1\| aminotransferase AlaT [Photobacterium profundum SS9], gi\|46914225\|emb\|C...	369.0	[0..1]	[404..1]
gi\|90410793, gi\|... - gi\|90410793\|ref\|ZP_01218808.1\| aspartate aminotransferase [Photobacterium profundum 3TCK], gi\|903284...	368.0	[0..1]	[404..1]
gi\|94310905, gi\|... - gi\|94310905\|ref\|YP_584115.1\| aminotransferase, class I and II [Ralstonia metallidurans CH34], gi\|933...	368.0	[0..2]	[404..46]
gi\|59480381, gi\|... - gi\|59712280\|ref\|YP_205056.1\| aminotransferase AlaT [Vibrio fischeri ES114], gi\|59480381\|gb\|AAW86168.... gi\|197316739, gi... - gi\|197335249\|ref\|YP_002156493.1\| aminotransferase, class I and II [Vibrio fischeri MJ11], gi\|1973167...	367.0	[0..1]	[404..1]
gi\|145588624, gi... - gi\|145588624\|ref\|YP_001155221.1\| aminotransferase AlaT [Polynucleobacter necessarius subsp. asymbiot...	367.0	[0..1]	[404..1]

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Predicted Domain #1

Region A:
Residues: [1-405]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPIEKSSKL ENVCYDIRGP VLKEAKRLEE EGNKVLKLNI GNPAPFGFDA PDEILVDVIR  60
   61 NLPTAQGYCD SKGLYSARKA IMQHYQARGM RDVTVEDIYI GNGVSELIVQ AMQALLNSGD 120
  121 EMLVPAPDYP LWTAAVSLSS GKAVHYLCDE SSDWFPDLDD IRAKITPRTR GIVIINPNNP 180
  181 TGAVYSKELL MEIVEIARQH NLIIFADEIY DKILYDDAEH HSIAPLAPDL LTITFNGLSK 240
  241 TYRVAGFRQG WMVLNGPKKH AKGYIEGLEM LASMRLCANV PAQHAIQTAL GGYQSISEFI 300
  301 TPGGRLYEQR NRAWELINDI PGVSCVKPRG ALYMFPKIDA KRFNIHDDQK MVLDFLLQEK 360
  361 VLLVQGTAFN WPWPDHFRIV TLPRVDDIEL SLSKFARFLS GYHQL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	92.154902
Match:	1xi9A
Description:	Alanine aminotransferase from Pyrococcus furiosus Pfu-1397077-001
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
L-aspartate:2-oxoglutarate aminotransferase activity	5.51961002550688	bayes_pls_golite062009
catalytic activity	2.29878871754893	bayes_pls_golite062009
4-aminobutyrate transaminase activity	1.82501790383768	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor	1.63055151623667	bayes_pls_golite062009
glycine dehydrogenase (decarboxylating) activity	1.63055151623667	bayes_pls_golite062009
transferase activity	1.44093490824786	bayes_pls_golite062009
transferase activity, transferring nitrogenous groups	1.28316822767388	bayes_pls_golite062009
transaminase activity	1.24990480711889	bayes_pls_golite062009
hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances	0.942545094747784	bayes_pls_golite062009
hydrolase activity, acting on acid carbon-carbon bonds	0.845816961387768	bayes_pls_golite062009
transferase activity, transferring acyl groups	0.319452731970428	bayes_pls_golite062009
pyridoxal phosphate binding	0.16957228630576	bayes_pls_golite062009
vitamin B6 binding	0.16957228630576	bayes_pls_golite062009
binding	0.107301373746935	bayes_pls_golite062009
aromatic-amino-acid:2-oxoglutarate aminotransferase activity	0.0916183433120769	bayes_pls_golite062009
kynureninase activity	0.0900983660305177	bayes_pls_golite062009
cystathionine beta-lyase activity	0.0833010353195099	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: