YRC Public Data Repository - Protein Structure Prediction

Protein:	YCJW_ECOLI
Organism:	Escherichia coli
Length:	332 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YCJW_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|167038831, gi... - gi\|167038831\|ref\|YP_001661816.1\| periplasmic binding protein/LacI transcriptional regulator [Thermoa... gi\|242258204, gi... - gi\|242258204\|ref\|ZP_04803030.1\| transcriptional regulator, LacI family [Thermoanaerobacter sp. X513]...	362.0	[0..1]	[332..1]
gi\|20515183, gi\|... - gi\|20806727\|ref\|NP_621898.1\| transcriptional regulator [Thermoanaerobacter tengcongensis MB4], gi\|20... gi\|20806727 - gi\|20806727\|ref\|NP_621898.1\| Transcriptional regulator [Thermoanaerobacter tengcongensis MB4] gi\|254478068, gi... - gi\|254478068\|ref\|ZP_05091451.1\| Periplasmic binding proteins and sugar binding domain of the LacI fa...	361.0	[0..1]	[332..1]
gi\|89209818, gi\|... - gi\|89209818\|ref\|ZP_01188212.1\| regulatory protein, LacI:Periplasmic binding protein/LacI transcripti...	351.0	[0..1]	[332..1]
gi\|76797419, gi\|... - gi\|76797419\|ref\|ZP_00779738.1\| regulatory protein, LacI:Periplasmic binding protein/LacI transcripti... gi\|241882990, gi... - gi\|241904637\|ref\|ZP_04789316.1\| transcriptional regulator, LacI family [Thermoanaerobacter brockii s...	351.0	[0..1]	[332..1]
gi\|51891908, gi\|... - gi\|51891908\|ref\|YP_074599.1\| LacI family transcriptional repressor [Symbiobacterium thermophilum IAM...	345.0	[0..4]	[332..2]
gi\|56380278, gi\|... - gi\|56420436\|ref\|YP_147754.1\| LacI family transcriptional regulator [Geobacillus kaustophilus HTA426]...	343.0	[0..1]	[332..1]

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Predicted Domain #1

Region A:
Residues: [1-332]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPTIYDIAR VAGVSKSTVS RVLNKQTNIS PEAREKVLRA IEELQYQPNK LARALTSSGF  60
   61 DAIMVISTRS TKTTAGNPFF SEVLHAITAK AEEEGFDVIL QTSHNPAEDL QKCESKIKQK 120
  121 MIKGIIMLSS PADESFFAQL DKYDIPVVVI GKVEGQYAHV YSVDTDNFGD SIALTDALIE 180
  181 SGHQNIACLH APLDVHVSVD RVNGYKQSLA AHNIAVRDEW IVDGGYTHET ALKAARQLLS 240
  241 QSPLPEAVFA TDSLKLMSIY RAAAEKNIAI PQQLAVVGYS NETLSFILTP APGGIDVPTQ 300
  301 ELGQQSCELL FRLISGKPSP QNITVATHMT LK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.221849
Match:	1rzrG
Description:	crystal structure of transcriptional regulator-phosphoprotein-DNA complex
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
transcription regulator activity	3.56046382984539	bayes_pls_golite062009
DNA binding	2.83896385348242	bayes_pls_golite062009
nucleic acid binding	2.80027597752699	bayes_pls_golite062009
transcription factor activity	2.66587775072853	bayes_pls_golite062009
binding	2.28053989162516	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.39285787026752	bayes_pls_golite062009
sequence-specific DNA binding	1.24210127552529	bayes_pls_golite062009
transporter activity	0.69447727045719	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	0.613419400163686	bayes_pls_golite062009
receptor activity	0.581432737510315	bayes_pls_golite062009
transmembrane transporter activity	0.537625088427333	bayes_pls_golite062009
transmembrane receptor activity	0.244777496593902	bayes_pls_golite062009
protein binding	0.186782087158009	bayes_pls_golite062009
G-protein coupled receptor activity	0.1760601003859	bayes_pls_golite062009
transcription factor binding	0.1642679595723	bayes_pls_golite062009
transcription cofactor activity	0.0349218665655747	bayes_pls_golite062009
substrate-specific transporter activity	0.00441561491566994	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: