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View Structure Prediction Details

Protein: TRER_ECOLI
Organism: Escherichia coli
Length: 315 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRER_ECOLI.

Description E-value Query
Range
Subject
Range
gi|20807285 - gi|20807285|ref|NP_622456.1| Transcriptional regulator [Thermoanaerobacter tengcongensis MB4]
gi|20807285, gi|... - gi|20807285|ref|NP_622456.1| transcriptional regulator [Thermoanaerobacter tengcongensis MB4], gi|20...
334.0 [0..5] [314..2]
gi|76797419, gi|... - gi|76797419|ref|ZP_00779738.1| regulatory protein, LacI:Periplasmic binding protein/LacI transcripti...
gi|241882990, gi... - gi|241904637|ref|ZP_04789316.1| transcriptional regulator, LacI family [Thermoanaerobacter brockii s...
332.0 [0..5] [314..3]
gi|167038831, gi... - gi|167038831|ref|YP_001661816.1| periplasmic binding protein/LacI transcriptional regulator [Thermoa...
gi|242258204, gi... - gi|242258204|ref|ZP_04803030.1| transcriptional regulator, LacI family [Thermoanaerobacter sp. X513]...
331.0 [0..5] [314..3]
gi|89209818, gi|... - gi|89209818|ref|ZP_01188212.1| regulatory protein, LacI:Periplasmic binding protein/LacI transcripti...
323.0 [0..4] [314..2]
gi|82401152, gi|... - gi|82500860|ref|ZP_00886253.1| regulatory protein, LacI [Caldicellulosiruptor saccharolyticus DSM 89...
321.0 [0..2] [314..9]
gi|51891908, gi|... - gi|51891908|ref|YP_074599.1| LacI family transcriptional repressor [Symbiobacterium thermophilum IAM...
319.0 [0..5] [314..1]

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Predicted Domain #1
Region A:
Residues: [1-62]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNRLTIKDI ARLSGVGKST VSRVLNNESG VSQLTRERVE AVMNQHGFSP SRSARAMRGQ  60
   61 SD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.154902
Match: 2bjcA
Description: NMR structure of a protein-DNA complex of an altered specificity mutant of the lac repressor that mimics the gal repressor
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 3.60509310049517 bayes_pls_golite062009
transcription regulator activity 3.48897156115814 bayes_pls_golite062009
nucleic acid binding 3.34114111237501 bayes_pls_golite062009
binding 2.84855827811506 bayes_pls_golite062009
transcription factor activity 2.15956406789231 bayes_pls_golite062009
catalytic activity 0.374904657353081 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.29966985317584 bayes_pls_golite062009
sequence-specific DNA binding 0.11459677079129 bayes_pls_golite062009
transcription repressor activity 0.0485771867742395 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [63-315]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVVAIIVTRL DSLSENLAVQ TMLPAFYEQG YDPIMMESQF SPQLVAEHLG VLKRRNIDGV  60
   61 VLFGFTGITE EMLAHWQSSL VLLARDAKGF ASVCYDDEGA IKILMQRLYD QGHRNISYLG 120
  121 VPHSDVTTGK RRHEAYLAFC KAHKLHPVAA LPGLAMKQGY ENVAKVITPE TTALLCATDT 180
  181 LALGASKYLQ EQRIDTLQLA SVGNTPLMKF LHPEIVTVDP GYAEAGRQAA CQLIAQVTGR 240
  241 SEPQQIIIPA TLS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.0
Match: 1bykA
Description: Trehalose repressor, C-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.03730517010624 bayes_pls_golite062009
DNA binding 2.13752511265098 bayes_pls_golite062009
transcription factor activity 2.10452652023643 bayes_pls_golite062009
nucleic acid binding 2.05471649974481 bayes_pls_golite062009
binding 1.58080550382179 bayes_pls_golite062009
signal transducer activity 0.11302624216037 bayes_pls_golite062009
molecular transducer activity 0.11302624216037 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle