YRC Public Data Repository - Protein Structure Prediction

Protein:	THRC_ECOLI
Organism:	Escherichia coli
Length:	428 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for THRC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|238795007, gi... - gi\|77976934\|ref\|ZP_00832399.1\| COG0498: Threonine synthase [Yersinia intermedia ATCC 29909], gi\|2387...	380.0	[0..1]	[427..1]
gi\|37524571, gi\|... - gi\|37524571\|ref\|NP_927915.1\| threonine synthase [Photorhabdus luminescens subsp. laumondii TTO1], gi...	380.0	[0..1]	[426..1]
gi\|74277383, gi\|... - gi\|75428855\|ref\|ZP_00731923.1\| Threonine synthase [Actinobacillus succinogenes 130Z], gi\|74277383\|gb...	379.0	[0..1]	[425..1]
gi\|53732619 - gi\|53732619\|ref\|ZP_00154816.2\| COG0498: Threonine synthase [Haemophilus influenzae R2846]	378.0	[0..1]	[425..1]
gi\|77961947, gi\|... - gi\|77961947\|ref\|ZP_00825775.1\| COG0498: Threonine synthase [Yersinia mollaretii ATCC 43969], gi\|2387...	376.0	[0..1]	[427..1]
gi\|32034857 - gi\|32034857\|ref\|ZP_00134963.1\| COG0498: Threonine synthase [Actinobacillus pleuropneumoniae serovar ... gi\|126097755, gi... - gi\|126208963\|ref\|YP_001054188.1\| threonine synthase [Actinobacillus pleuropneumoniae L20], gi\|126097...	376.0	[0..1]	[425..1]
gi\|145639588, gi... - gi\|145639588\|ref\|ZP_01795192.1\| threonine synthase [Haemophilus influenzae PittII], gi\|145271379\|gb\|... gi\|144978539, gi... - gi\|145629036\|ref\|ZP_01784835.1\| threonine synthase [Haemophilus influenzae 22.1-21], gi\|144978539\|gb... gi\|46133760 - gi\|46133760\|ref\|ZP_00157680.2\| COG0498: Threonine synthase [Haemophilus influenzae R2866]	376.0	[0..1]	[425..1]
gi\|110613625, gi... - gi\|110804077\|ref\|YP_687597.1\| threonine synthase [Shigella flexneri 5 str. 8401], gi\|110613625\|gb\|AB... gi\|30061575, gi\|... - gi\|30061575\|ref\|NP_835746.1\| threonine synthase [Shigella flexneri 2a str. 2457T], gi\|30039817\|gb\|AA...	375.0	[0..1]	[428..1]
THRC_HAEIN - Threonine synthase OS=Haemophilus influenzae GN=thrC PE=3 SV=1 THRC_HAEIN - Threonine synthase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=thrC PE=...	375.0	[0..1]	[425..1]
gi\|193065648, gi... - gi\|75256316\|ref\|ZP_00727988.1\| COG0498: Threonine synthase [Escherichia coli E22], gi\|193065648\|ref\|... gi\|194429170, gi... - gi\|75209608\|ref\|ZP_00709826.1\| COG0498: Threonine synthase [Escherichia coli B171], gi\|194429170\|ref...	375.0	[0..1]	[428..1]

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Predicted Domain #1

Region A:
Residues: [1-428]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLYNLKDHN EQVSFAQAVT QGLGKNQGLF FPHDLPEFSL TEIDEMLKLD FVTRSAKILS  60
   61 AFIGDEIPQE ILEERVRAAF AFPAPVANVE SDVGCLELFH GPTLAFKDFG GRFMAQMLTH 120
  121 IAGDKPVTIL TATSGDTGAA VAHAFYGLPN VKVVILYPRG KISPLQEKLF CTLGGNIETV 180
  181 AIDGDFDACQ ALVKQAFDDE ELKVALGLNS ANSINISRLL AQICYYFEAV AQLPQETRNQ 240
  241 LVVSVPSGNF GDLTAGLLAK SLGLPVKRFI AATNVNDTVP RFLHDGQWSP KATQATLSNA 300
  301 MDVSQPNNWP RVEELFRRKI WQLKELGYAA VDDETTQQTM RELKELGYTS EPHAAVAYRA 360
  361 LRDQLNPGEY GLFLGTAHPA KFKESVEAIL GETLDLPKEL AERADLPLLS HNLPADFAAL 420
  421 RKLMMNHQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	104.0
Match:	1vb3A
Description:	Crystal Structure of Threonine Synthase from Escherichia coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
threonine synthase activity	3.59927532963055	bayes_pls_golite062009
carbon-oxygen lyase activity, acting on phosphates	2.61572425646119	bayes_pls_golite062009
catalytic activity	2.38994231321972	bayes_pls_golite062009
lyase activity	1.87743897464083	bayes_pls_golite062009
cysteine synthase activity	1.31641967296632	bayes_pls_golite062009
binding	1.19751827446411	bayes_pls_golite062009
tryptophan synthase activity	1.04832999357666	bayes_pls_golite062009
carbon-oxygen lyase activity	0.923824749425553	bayes_pls_golite062009
ammonia-lyase activity	0.476674617721478	bayes_pls_golite062009
L-threonine ammonia-lyase activity	0.37325071016009	bayes_pls_golite062009
protein binding	0.251404253093929	bayes_pls_golite062009
carbon-nitrogen lyase activity	0.249761226675912	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: