YRC Public Data Repository - Protein Structure Prediction

Protein:	PTYC_ECOLI, PTMC...
Organism:	Escherichia coli
Length:	462 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PTYC_ECOLI, PTMC....

Description	E-value	Query Range	Subject Range
gi\|52424466, gi\|... - gi\|52424466\|ref\|YP_087603.1\| MtlA protein [Mannheimia succiniciproducens MBEL55E], gi\|52306518\|gb\|AA...	318.0	[0..1]	[459..1]
gi\|28897144, gi\|... - gi\|28897144\|ref\|NP_796749.1\| PTS system, mannitol-specific IIABC component [Vibrio parahaemolyticus ... gi\|28805353 - gi\|28805353\|dbj\|BAC58633.1\| PTS system, mannitol-specific IIABC component [Vibrio parahaemolyticus R...	317.0	[0..1]	[462..1]
gi\|62182179, gi\|... - gi\|62182179\|ref\|YP_218596.1\| PTS family, mannitol-specific enzyme IIABC components [Salmonella enter...	317.0	[0..3]	[462..2]
gi\|75228662, gi\|... - gi\|75228662\|ref\|ZP_00715283.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|75188362, gi\|... - gi\|75188362\|ref\|ZP_00701629.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|75179770, gi\|... - gi\|75179770\|ref\|ZP_00699757.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|170018170, gi... - gi\|170018170\|ref\|YP_001723124.1\| PTS system, mannitol-specific IIC subunit [Escherichia coli ATCC 87... gi\|73857644, gi\|... - gi\|74314167\|ref\|YP_312586.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella sonnei ... gi\|75255815, gi\|... - gi\|75255815\|ref\|ZP_00727561.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|124499171, gi... - gi\|124530530\|ref\|ZP_01701157.1\| PTS system, mannitol-specific IIC subunit [Escherichia coli B], gi\|1...	316.0	[0..3]	[462..2]
gi\|30065127, gi\|... - gi\|30065127\|ref\|NP_839298.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella flexner... gi\|24114863, gi\|... - gi\|24114863\|ref\|NP_709373.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella flexner... gi\|110617279, gi... - gi\|110807731\|ref\|YP_691251.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella flexne...	316.0	[0..3]	[462..2]
gi\|227839344, gi... - gi\|227883764\|ref\|ZP_04001569.1\| protein-N(pi)-phosphohistidine--sugar phosphotransferase [Escherichi... gi\|110345432, gi... - gi\|110643840\|ref\|YP_671570.1\| PTS system, mannitol-specific IIABC component [Escherichia coli 536], ... gi\|215266950, gi... - gi\|215488878\|ref\|YP_002331309.1\| fused mannitol-specific PTS enzymes: IIA components /IIB components... gi\|218691882, gi... - gi\|218691882\|ref\|YP_002400094.1\| fused mannitol-specific PTS enzymes: IIA components ; IIB component... gi\|26250238, gi\|... - gi\|26250238\|ref\|NP_756278.1\| PTS system, mannitol-specific IIABC component [Escherichia coli CFT073]... gi\|191170342, gi... - gi\|75242618\|ref\|ZP_00726362.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ...	316.0	[0..3]	[462..2]
PTM3C_PASMU - PTS system mannitol-specific EIICBA component OS=Pasteurella multocida (strain Pm70) GN=mtlA PE=3 SV... PTM3C_PASMU, PTM... - (Q9CLY8) PTS system, mannitol-specific IIABC component (EIIABC-Mtl) (Mannitol-permease IIABC compone...	316.0	[0..1]	[460..1]
gi\|194414527, gi... - gi\|75211354\|ref\|ZP_00711453.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ...	316.0	[0..3]	[462..2]
gi\|12721397, gi\|... - gi\|15602926\|ref\|NP_245998.1\| PtmA [Pasteurella multocida subsp. multocida str. Pm70], gi\|12721397\|gb...	316.0	[0..1]	[460..10]
gi\|168779748, gi... - gi\|189002293\|gb\|EDU71279.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|209747460, gi... - pir\|\|C91188 hypothetical protein ECs4475 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|189380162, gi... - gi\|189380162\|gb\|EDU98578.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|195935125 - gi\|195935125\|ref\|ZP_03080507.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia co... gi\|208725580, gi... - gi\|208805779\|ref\|ZP_03248116.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157... gi\|168753416, gi... - gi\|189358801\|gb\|EDU77220.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|168759690, gi... - gi\|189369645\|gb\|EDU88061.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|15833729, gi\|... - gi\|15833729\|ref\|NP_312502.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia coli ... gi\|189364590, gi... - gi\|189364590\|gb\|EDU83009.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|187771479, gi... - gi\|187771479\|gb\|EDU35323.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|254795553, gi... - gi\|254795553\|ref\|YP_003080390.1\| fused mannitol-specific PTS enzymes: IIA components, IIB components... gi\|188018385, gi... - gi\|188018385\|gb\|EDU56507.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|15833729, gi\|... - gi\|15833729\|ref\|NP_312502.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia coli ... gi\|208812259, gi... - gi\|208812259\|ref\|ZP_03253588.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157... gi\|208740178, gi... - gi\|208820055\|ref\|ZP_03260375.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157... gi\|209158199, gi... - gi\|209396799\|ref\|YP_002273078.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O15... gi\|217326167, gi... - gi\|217326167\|ref\|ZP_03442251.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157...	316.0	[0..3]	[462..2]

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Predicted Domain #1

Region A:
Residues: [1-94]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENKSARAKV QAFGGFLTAM VIPNIGAFIA WGFITALFIP TGWLPNEHFA KIVGPMITYL  60
   61 LPVMIGSTGG HLVGGKRGAV MGGIGTIGVI VGAE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [95-357]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPMFLGSMIM GPLGGLVIKY VDKALEKRIP AGFEMVINNF SLGIAGMLLC LLGFEVIGPA  60
   61 VLIANTFVKE CIEALVHAGY LPLLSVINEP AKVLFLNNAI DQGVYYPLGM QQASVNGKSI 120
  121 FFMVASNPGP GLGLLLAFTL FGKGMSKRSA PGAMIIHFLG GIHELYFPYV LMKPLTIIAM 180
  181 IAGGMSGTWM FNLLDGGLVA GPSPGSIFAY LALTPKGSFL ATIAGVTVGT LVSFAITSLI 240
  241 LKMEKTVETE SEDEFAQSAN AVK

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [358-462]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AMKQEGAFSL SRVKRIAFVC DAGMGSSAMG ATTFRKRLEK AGLAIEVKHY AIENVPADAD  60
   61 IVVTHASLEG RVKRVTDKPL ILINNYIGDP KLDTLFNQLT AEHKH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.69897
Match:	1vkrA
Description:	STRUCTURE OF IIB DOMAIN OF THE MANNITOL-SPECIFIC PERMEASE ENZYME II
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	5.08041453921791	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	4.49138214292642	bayes_pls_golite062009
sugar transmembrane transporter activity	1.77053981674308	bayes_pls_golite062009
transporter activity	1.6837050020547	bayes_pls_golite062009
transmembrane transporter activity	1.5685227361887	bayes_pls_golite062009
substrate-specific transporter activity	1.32293422112884	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.217268678967	bayes_pls_golite062009
active transmembrane transporter activity	1.12964417923438	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	0.71593290802554	bayes_pls_golite062009
binding	0.472595683811139	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.37663629577414	bayes_pls_golite062009
fructose transmembrane transporter activity	0.225562559709031	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0296784994545702	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: