YRC Public Data Repository - Protein Structure Prediction

Protein:	PPIB_ECOLI
Organism:	Escherichia coli
Length:	164 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PPIB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|50301248 - gi\|50301248\|gb\|AAT73777.1\| TRIM5/cyclophilin A fusion protein [Aotus trivirgatus]	215.0	[0..2]	[163..316]
gi\|91770247, gi\|... - gi\|91770247\|ref\|ZP_01272075.1\| Peptidylprolyl isomerase [Psychrobacter sp. PRwf-1], gi\|91720718\|gb\|E...	213.0	[0..1]	[163..30]
gi\|17428178 - gi\|17428178\|emb\|CAD14866.1\| probable peptidyl-prolyl cis-trans isomerase b (ppiase b) (rotamase b)(c... gi\|17545883 - gi\|17545883\|ref\|NP_519285.1\| peptidyl-prolyl cis-trans isomerase B [Ralstonia solanacearum GMI1000]	211.0	[0..2]	[164..15]
gi\|91784178, gi\|... - gi\|91784178\|ref\|YP_559384.1\| peptidylprolyl isomerase [Burkholderia xenovorans LB400], gi\|91688132\|g...	211.0	[0..1]	[164..1]
PPIB_STRAT - Peptidyl-prolyl cis-trans isomerase cyp18 OS=Streptomyces antibioticus GN=cyp18 PE=1 SV=3	210.0	[0..2]	[163..4]
gi\|77165714, gi\|... - gi\|77165714\|ref\|YP_344239.1\| peptidylprolyl isomerase [Nitrosococcus oceani ATCC 19707], gi\|76884028... gi\|207089446 - gi\|207089446\|gb\|EDZ66717.1\| peptidyl-prolyl cis-trans isomerase, cyclophilin-type, putative [Nitroso... gi\|254433113, gi... - gi\|254433113\|ref\|ZP_05046621.1\| peptidyl-prolyl cis-trans isomerase, cyclophilin-type, putative [Nit...	210.0	[0..2]	[164..34]
gi\|145589041, gi... - gi\|145589041\|ref\|YP_001155638.1\| peptidylprolyl isomerase [Polynucleobacter necessarius subsp. asymb...	210.0	[0..2]	[164..4]
gi\|238790850, gi... - gi\|77974236\|ref\|ZP_00829777.1\| COG0652: Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin...	209.0	[0..1]	[164..1]
gi\|238785351, gi... - gi\|77958383\|ref\|ZP_00822417.1\| COG0652: Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin... gi\|238720558, gi... - gi\|77962149\|ref\|ZP_00825973.1\| COG0652: Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin...	209.0	[0..1]	[164..1]

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Predicted Domain #1

Region A:
Residues: [1-164]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTFHTNHGD IVIKTFDDKA PETVKNFLDY CREGFYNNTI FHRVINGFMI QGGGFEPGMK  60
   61 QKATKEPIKN EANNGLKNTR GTLAMARTQA PHSATAQFFI NVVDNDFLNF SGESLQGWGY 120
  121 CVFAEVVDGM DVVDKIKGVA TGRSGMHQDV PKEDVIIESV TVSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	53.69897
Match:	2nulA
Description:	PEPTIDYLPROLYL ISOMERASE FROM E. COLI
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein deacetylase activity	4.3775483906311	bayes_pls_golite062009
histone deacetylase activity	4.29026678196473	bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity	3.73853378771688	bayes_pls_golite062009
cis-trans isomerase activity	3.66963215732405	bayes_pls_golite062009
deacetylase activity	3.49940864924766	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	3.01511519120932	bayes_pls_golite062009
RNA binding	2.94609837984526	bayes_pls_golite062009
isomerase activity	1.96529188741504	bayes_pls_golite062009
binding	1.51078436090781	bayes_pls_golite062009
mRNA binding	1.45537055700871	bayes_pls_golite062009
unfolded protein binding	1.38124355054041	bayes_pls_golite062009
nucleic acid binding	0.939772862764466	bayes_pls_golite062009
catalytic activity	0.748655649755714	bayes_pls_golite062009
hydrolase activity	0.493806105600863	bayes_pls_golite062009
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	0.408539130322443	bayes_pls_golite062009
drug binding	0.36339132904137	bayes_pls_golite062009
ubiquitin-protein ligase activity	0.322244688184474	bayes_pls_golite062009
small conjugating protein ligase activity	0.286133802341887	bayes_pls_golite062009
histone binding	0.268719695649015	bayes_pls_golite062009
protein binding	0.253009105026943	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: