YRC Public Data Repository - Protein Structure Prediction

Protein:	OXC_ECOLI
Organism:	Escherichia coli
Length:	564 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for OXC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|219993234, gi... - gi\|89210057\|ref\|ZP_01188450.1\| Acetolactate synthase, large subunit, biosynthetic type [Halothermoth...	575.0	[0..5]	[563..1]
gi\|91202797 - gi\|91202797\|emb\|CAJ72436.1\| strongly similar to acetohydroxy acid synthase IilvB [Candidatus Kueneni...	573.0	[0..3]	[564..6]
gi\|106884385, gi... - gi\|119947033\|ref\|YP_944713.1\| acetolactate synthase, large subunit, biosynthetic type [Psychromonas ...	573.0	[0..5]	[561..1]
gi\|17232105, gi\|... - gi\|17232105\|ref\|NP_488653.1\| acetolactate synthase 3 catalytic subunit [Nostoc sp. PCC 7120], gi\|171... gi\|25291313 - pir\|\|AE2382 acetohydroxy acid synthase [imported] - Nostoc sp. (strain PCC 7120)	572.0	[0..4]	[563..29]
gi\|75908969, gi\|... - gi\|75908969\|ref\|YP_323265.1\| acetolactate synthase 3 catalytic subunit [Anabaena variabilis ATCC 294...	572.0	[0..4]	[563..29]
gi\|72394929, gi\|... - gi\|73667767\|ref\|YP_303782.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina barkeri str. ...	570.0	[0..1]	[563..1]
gi\|88602528, gi\|... - gi\|88602528\|ref\|YP_502706.1\| acetolactate synthase, large subunit, biosynthetic type [Methanospirill...	568.0	[0..7]	[561..1]
gi\|222054607, gi... - gi\|222054607\|ref\|YP_002536969.1\| acetolactate synthase, large subunit, biosynthetic type [Geobacter ...	568.0	[0..6]	[563..1]
gi\|21226772, gi\|... - gi\|21226772\|ref\|NP_632694.1\| acetolactate synthase 3 catalytic subunit [Methanosarcina mazei Go1], g...	568.0	[0..1]	[563..1]
gi\|77977565 - gi\|77977565\|ref\|ZP_00833010.1\| COG0028: Thiamine pyrophosphate-requiring enzymes [acetolactate synth...	568.0	[0..2]	[561..8]

Back

Predicted Domain #1

Region A:
Residues: [1-564]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSDQLQMTDG MHIIVEALKQ NNIDTIYGVV GIPVTDMARH AQAEGIRYIG FRHEQSAGYA  60
   61 AAASGFLTQK PGICLTVSAP GFLNGLTALA NATVNGFPMI MISGSSDRAI VDLQQGDYEE 120
  121 LDQMNAAKPY AKAAFRVNQP QDLGIALARA IRVSVSGRPG GVYLDLPANV LAATMEKDEA 180
  181 LTTIVKVENP SPALLPCPKS VTSAISLLAK AERPLIILGK GAAYSQADEQ LREFIESAQI 240
  241 PFLPMSMAKG ILEDTHPLSA AAARSFALAN ADVVMLVGAR LNWLLAHGKK GWAADTQFIQ 300
  301 LDIEPQEIDS NRPIAVPVVG DIASSMQGML AELKQNTFTT PLVWRDILNI HKQQNAQKMH 360
  361 EKLSTDTQPL NYFNALSAVR DVLRENQDIY LVNEGANTLD NARNIIDMYK PRRRLDCGTW 420
  421 GVMGIGMGYA IGASVTSGSP VVAIEGDSAF GFSGMEIETI CRYNLPVTIV IFNNGGIYRG 480
  481 DGVDLSGAGA PSPTDLLHHA RYDKLMDAFR GVGYNVTTTD ELRHALTTGI QSRKPTIINV 540
  541 VIDPAAGTES GHITKLNPKQ VAGN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	107.0
Match:	2c31A
Description:	CRYSTAL STRUCTURE OF OXALYL-COA DECARBOXYLASE IN COMPLEX WITH THE COFACTOR DERIVATIVE THIAMIN-2-THIAZOLONE DIPHOSPHATE AND ADENOSINE DIPHOSPHATE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	12.903449876837	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	12.3239025230705	bayes_pls_golite062009
pyruvate dehydrogenase activity	5.28857071459273	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.21233670052586	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	5.08663245333808	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.15444163802756	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.98546381612935	bayes_pls_golite062009
thiamin pyrophosphate binding	1.87247313698582	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.82969293063325	bayes_pls_golite062009
transketolase activity	1.70348931648612	bayes_pls_golite062009
deoxyhypusine synthase activity	1.46517585302326	bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	1.07090849835369	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	1.0611726850452	bayes_pls_golite062009
protein deacetylase activity	0.882978552120903	bayes_pls_golite062009
histone deacetylase activity	0.881399086357632	bayes_pls_golite062009
cation transmembrane transporter activity	0.78591260444574	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	0.750929351082237	bayes_pls_golite062009
hydrolase activity	0.536729211484905	bayes_pls_golite062009
ion transmembrane transporter activity	0.51426028502998	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	0.492590326775569	bayes_pls_golite062009
oxidoreductase activity	0.459800433209317	bayes_pls_golite062009
transferase activity	0.413024577830522	bayes_pls_golite062009
NAD-dependent histone deacetylase activity	0.38348854354211	bayes_pls_golite062009
NAD-dependent protein deacetylase activity	0.38348854354211	bayes_pls_golite062009
deacetylase activity	0.382228826641711	bayes_pls_golite062009
transcription regulator activity	0.217707914161459	bayes_pls_golite062009
pyruvate decarboxylase activity	0.198062360371269	bayes_pls_golite062009
nucleic acid binding	0.0424046736878951	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: