YRC Public Data Repository - Protein Structure Prediction

Protein:	NRDD_ECOLI
Organism:	Escherichia coli
Length:	712 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NRDD_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|209749670, gi... - pir\|\|G91280 anaerobic ribonucleoside-triphosphate reductase [imported] - Escherichia coli (strain O1... gi\|12519242, gi\|... - gi\|15804828\|ref\|NP_290869.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli O157:... gi\|13364692, gi\|... - gi\|15834469\|ref\|NP_313242.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli O157:... gi\|254796258, gi... - gi\|254796258\|ref\|YP_003081095.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O... gi\|208733273, gi... - gi\|208811996\|ref\|ZP_03253325.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O1... gi\|208820712, gi... - gi\|208820712\|ref\|ZP_03261032.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O1... gi\|209157226, gi... - gi\|209395826\|ref\|YP_002273781.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O... gi\|217325941, gi... - gi\|217325941\|ref\|ZP_03442025.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O1... gi\|189374739, gi... - gi\|189374739\|gb\|EDU93155.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O157:H... gi\|189379431, gi... - gi\|189379431\|gb\|EDU97847.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O157:H... gi\|195937263 - gi\|195937263\|ref\|ZP_03082645.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli O1... gi\|208808013, gi... - gi\|208808013\|ref\|ZP_03250350.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O1... gi\|168760488, gi... - gi\|189368865\|gb\|EDU87281.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O157:H... gi\|189364193, gi... - gi\|189364193\|gb\|EDU82612.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O157:H... gi\|187770204, gi... - gi\|187770204\|gb\|EDU34048.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O157:H... gi\|188999753, gi... - gi\|188999753\|gb\|EDU68739.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O157:H... gi\|13364692, gi\|... - gi\|15834469\|ref\|NP_313242.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli O157:... gi\|168751072, gi... - gi\|188014840\|gb\|EDU52962.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O157:H... gi\|168754815, gi... - gi\|189357853\|gb\|EDU76272.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli O157:H...	904.0	[0..1]	[712..1]
gi\|194433892, gi... - gi\|83569389\|ref\|ZP_00920843.1\| COG1328: Oxygen-sensitive ribonucleoside-triphosphate reductase [Shig...	904.0	[0..1]	[712..1]
gi\|237703913, gi... - gi\|237703913\|ref\|ZP_04534394.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia sp. 3_2... gi\|190908995, gi... - gi\|75242374\|ref\|ZP_00726136.1\| COG1328: Oxygen-sensitive ribonucleoside-triphosphate reductase [Esch... gi\|115515708, gi... - gi\|117626584\|ref\|YP_859907.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli APEC... gi\|91075365, gi\|... - gi\|91213791\|ref\|YP_543777.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli UTI89... gi\|26251144, gi\|... - gi\|26251144\|ref\|NP_757184.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli CFT07... gi\|110644599, gi... - gi\|110644599\|ref\|YP_672329.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli 536]...	904.0	[0..1]	[712..1]
gi\|157157950, gi... - gi\|75188951\|ref\|ZP_00702218.1\| COG1328: Oxygen-sensitive ribonucleoside-triphosphate reductase [Esch...	903.0	[0..1]	[712..1]
gi\|170021751, gi... - gi\|170021751\|ref\|YP_001726705.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli A... gi\|218368167, gi... - gi\|218561398\|ref\|YP_002394311.1\| anaerobic ribonucleoside triphosphate reductase [Escherichia coli S... gi\|192956890, gi... - gi\|75235453\|ref\|ZP_00719661.1\| COG1328: Oxygen-sensitive ribonucleoside-triphosphate reductase [Esch... gi\|124500742, gi... - gi\|124528300\|ref\|ZP_01699624.1\| anaerobic ribonucleoside-triphosphate reductase [Escherichia coli B]...	903.0	[0..1]	[712..1]
gi\|146970 - gi\|146970\|gb\|AAA24226.1\| ribonucleoside triphosphate reductase gi\|146970 - gi\|146970\|gb\|AAA24226.1\| ribonucleoside triphosphate reductase	903.0	[0..1]	[712..1]
gi\|75515475, gi\|... - gi\|75515475\|ref\|ZP_00737632.1\| COG1328: Oxygen-sensitive ribonucleoside-triphosphate reductase [Esch... gi\|191167267, gi... - gi\|75229609\|ref\|ZP_00716148.1\| COG1328: Oxygen-sensitive ribonucleoside-triphosphate reductase [Esch...	903.0	[0..1]	[712..1]
gi\|81247926, gi\|... - gi\|82546515\|ref\|YP_410462.1\| anaerobic ribonucleoside triphosphate reductase [Shigella boydii Sb227]...	902.0	[0..1]	[712..1]
gi\|82779300, gi\|... - gi\|82779300\|ref\|YP_405649.1\| anaerobic ribonucleoside triphosphate reductase [Shigella dysenteriae S...	902.0	[0..1]	[712..1]
gi\|187731109, gi... - gi\|75179339\|ref\|ZP_00699343.1\| COG1328: Oxygen-sensitive ribonucleoside-triphosphate reductase [Shig...	901.0	[0..1]	[712..1]

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Predicted Domain #1

Region A:
Residues: [1-110]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTPHVMKRDG CKVPFKSERI KEAILRAAKA AEVDDADYCA TVAAVVSEQM QGRNQVDINE  60
   61 IQTAVENQLM SGPYKQLARA YIEYRHDRDI EREKRGRLNQ EIRGLVEQTN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.0
Match:	1zyzA
Description:	Structures of Yeast Ribonucloetide Reductase I
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [111-712]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ASLLNENANK DSKVIPTQRD LLAGIVAKHY ARQHLLPRDV VQAHERGDIH YHDLDYSPFF  60
   61 PMFNCMLIDL KGMLTQGFKM GNAEIEPPKS ISTATAVTAQ IIAQVASHIY GGTTINRIDE 120
  121 VLAPFVTASY NKHRKTAEEW NIPDAEGYAN SRTIKECYDA FQSLEYEVNT LHTANGQTPF 180
  181 VTFGFGLGTS WESRLIQESI LRNRIAGLGK NRKTAVFPKL VFAIRDGLNH KKGDPNYDIK 240
  241 QLALECASKR MYPDILNYDQ VVKVTGSFKT PMGCRSFLGV WENENGEQIH DGRNNLGVIS 300
  301 LNLPRIALEA KGDEATFWKL LDERLVLARK ALMTRIARLE GVKARVAPIL YMEGACGVRL 360
  361 NADDDVSEIF KNGRASISLG YIGIHETINA LFGGEHVYDN EQLRAKGIAI VERLRQAVDQ 420
  421 WKEETGYGFS LYSTPSENLC DRFCRLDTAE FGVVPGVTDK GYYTNSFHLD VEKKVNPYDK 480
  481 IDFEAPYPPL ANGGFICYGE YPNIQHNLKA LEDVWDYSYQ HVPYYGTNTP IDECYECGFT 540
  541 GEFECTSKGF TCPKCGNHDA SRVSVTRRVC GYLGSPDARP FNAGKQEEVK RRVKHLGNGQ 600
  601 IG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1h78A
Description:	Class III anaerobic ribonucleotide reductase NRDD subunit
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribonucleoside-triphosphate reductase activity	9.3477327019931	bayes_pls_golite062009
oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor	8.4227686174128	bayes_pls_golite062009
ribonucleoside-diphosphate reductase activity	7.9433005176339	bayes_pls_golite062009
oxidoreductase activity, acting on CH or CH2 groups	7.80351268764356	bayes_pls_golite062009
class III ribonucleotide reductase activity	5.84425109538191	bayes_pls_golite062009
CTP reductase activity	5.84425109538191	bayes_pls_golite062009
class I ribonucleotide reductase activity	3.5217325854654	bayes_pls_golite062009
catalytic activity	1.95058695475279	bayes_pls_golite062009
oxidoreductase activity	0.610428948300511	bayes_pls_golite062009
binding	0.314904881128799	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: