YRC Public Data Repository - Protein Structure Prediction

Protein:	KDUD_ECOLI
Organism:	Escherichia coli
Length:	253 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for KDUD_ECOLI.

Description	E-value	Query Range	Subject Range
FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima GN=fabG PE=3 SV=1 FABG_THEMA - 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / D...	276.0	[0..6]	[251..1]
gi\|146296617, gi... - gi\|82501013\|ref\|ZP_00886394.1\| 3-oxoacyl-(acyl-carrier-protein) reductase [Caldicellulosiruptor sacc...	270.0	[0..5]	[252..1]
gi\|115250215, gi... - gi\|126698778\|ref\|YP_001087675.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile 6... gi\|255306086 - gi\|255306086\|ref\|ZP_05350258.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile AT... gi\|255100197 - gi\|255100197\|ref\|ZP_05329174.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC...	270.0	[0..5]	[253..1]
gi\|255313843 - gi\|255313843\|ref\|ZP_05355426.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255516524 - gi\|255516524\|ref\|ZP_05384200.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255649624 - gi\|255649624\|ref\|ZP_05396526.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|254974717 - gi\|254974717\|ref\|ZP_05271189.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile QC... gi\|255092105 - gi\|255092105\|ref\|ZP_05321583.1\| 3-oxoacyl-[acyl-carrier protein] reductase [Clostridium difficile CI... gi\|90575404, gi\|... - gi\|90575404\|ref\|ZP_01231888.1\| hypothetical protein CdifQ_02001165 [Clostridium difficile QCD-32g58]...	269.0	[0..5]	[253..1]
gi\|18310052, gi\|... - gi\|18310052\|ref\|NP_561986.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens st...	269.0	[0..8]	[252..2]
gi\|89098688, gi\|... - gi\|89098688\|ref\|ZP_01171570.1\| beta-ketoacyl-acyl carrier protein reductase [Bacillus sp. NRRL B-149...	267.0	[0..6]	[252..1]
gi\|168210762, gi... - gi\|170711222\|gb\|EDT23404.1\| 3-oxoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens B st... gi\|110675446, gi... - gi\|110800799\|ref\|YP_695772.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens A... gi\|170660709, gi... - gi\|170660709\|gb\|EDT13392.1\| 3-oxoacyl- reductase [Clostridium perfringens E str. JGS1987], gi\|168207...	265.0	[0..8]	[252..2]
gi\|91184216, gi\|... - gi\|91217712\|ref\|ZP_01254669.1\| putative 3-oxoacyl-[acyl-carrier protein] reductase [Psychroflexus to...	265.0	[0..2]	[251..5]
gi\|110803752, gi... - gi\|110803752\|ref\|YP_698460.1\| 3-ketoacyl-(acyl-carrier-protein) reductase [Clostridium perfringens S...	264.0	[0..8]	[252..2]
gi\|219540094, gi... - gi\|68206640\|ref\|ZP_00558823.1\| Glucose/ribitol dehydrogenase [Desulfitobacterium hafniense DCB-2], g...	262.0	[0..6]	[252..1]

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Predicted Domain #1

Region A:
Residues: [1-253]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MILSAFSLEG KVAVVTGCDT GLGQGMALGL AQAGCDIVGI NIVEPTETIE QVTALGRRFL  60
   61 SLTADLRKID GIPALLDRAV AEFGHIDILV NNAGLIRRED ALEFSEKDWD DVMNLNIKSV 120
  121 FFMSQAAAKH FIAQGNGGKI INIASMLSFQ GGIRVPSYTA SKSGVMGVTR LMANEWAKHN 180
  181 INVNAIAPGY MATNNTQQLR ADEQRSAEIL DRIPAGRWGL PSDLMGPIVF LASSASDYVN 240
  241 GYTIAVDGGW LAR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	69.221849
Match:	1vl8A
Description:	Crystal structure of Gluconate 5-dehydrogenase (TM0441) from Thermotoga maritima at 2.07 A resolution
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	3.09625241707629	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	3.06391460989761	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-CH group of donors	3.02758902218302	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	2.66329970371321	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	1.81060491890041	bayes_pls_golite062009
catalytic activity	1.79741889688267	bayes_pls_golite062009
steroid dehydrogenase activity	1.75109362865449	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	1.65338499044318	bayes_pls_golite062009
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.55012034958204	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.47309297191111	bayes_pls_golite062009
fatty acid synthase activity	1.23679054027553	bayes_pls_golite062009
sorbose reductase activity	1.06293597394863	bayes_pls_golite062009
binding	0.784517759335365	bayes_pls_golite062009
3-oxoacyl-[acyl-carrier-protein] reductase activity	0.604742541607263	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	0.576163737662951	bayes_pls_golite062009
DNA binding	0.525227236870065	bayes_pls_golite062009
nucleic acid binding	0.459537641913493	bayes_pls_golite062009
enoyl-CoA hydratase activity	0.439912268968251	bayes_pls_golite062009
transcription regulator activity	0.152651308844322	bayes_pls_golite062009
inorganic cation transmembrane transporter activity	0.0913823272876781	bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity	0.00644214957417527	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: