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View Structure Prediction Details

Protein: HSCA_ECOLI
Organism: Escherichia coli
Length: 616 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSCA_ECOLI.

Description E-value Query
Range		 Subject
Range
gi|34784832 - gi|34784832|gb|AAH56709.1| Hsp70 protein [Danio rerio]
 656.0 [0..14] [616..1]
gi|3004463 - gi|3004463|emb|CAA04673.1| heat shock protein 70 [Oreochromis mossambicus]
 654.0 [0..18] [616..4]
HSP71_ORYLA - Heat shock 70 kDa protein 1 OS=Oryzias latipes PE=3 SV=1
 653.0 [0..14] [616..1]
gi|82941224 - gi|82941224|dbj|BAE48743.1| heat shock cognate 70 [Plutella xylostella]
 652.0 [0..18] [616..4]
HS71L_MACFA - Heat shock 70 kDa protein 1-like OS=Macaca fascicularis GN=HSPA1L PE=2 SV=1
gi|109070526, gi... - gi|109070526|ref|XP_001113356.1| PREDICTED: similar to heat shock 70kDa protein 1-like isoform 3 [Ma...
 651.0 [0..14] [616..1]
gi|20559 - gi|20559|emb|CAA31663.1| hsp70 (AA 6 - 651) [Petunia x hybrida]
 651.0 [0..18] [616..1]
gi|111306225, gi... - gi|118404236|ref|NP_001072429.1| heat shock 70kDa protein 1-like [Xenopus (Silurana) tropicalis], gi...
 651.0 [0..16] [616..2]

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Predicted Domain #1
Region A:
Residues: [1-551] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLQISEPG LSAAPHQRRL AAGIDLGTTN SLVATVRSGQ AETLADHEGR HLLPSVVHYQ  60
   61 QQGHSVGYDA RTNAALDTAN TISSVKRLMG RSLADIQQRY PHLPYQFQAS ENGLPMIETA 120
  121 AGLLNPVRVS ADILKALAAR ATEALAGELD GVVITVPAYF DDAQRQGTKD AARLAGLHVL 180
  181 RLLNEPTAAA IAYGLDSGQE GVIAVYDLGG GTFDISILRL SRGVFEVLAT GGDSALGGDD 240
  241 FDHLLADYIR EQAGIPDRSD NRVQRELLDA AIAAKIALSD ADSVTVNVAG WQGEISREQF 300
  301 NELIAPLVKR TLLACRRALK DAGVEADEVL EVVMVGGSTR VPLVRERVGE FFGRPPLTSI 360
  361 DPDKVVAIGA AIQADILVGN KPDSEMLLLD VIPLSLGLET MGGLVEKVIP RNTTIPVARA 420
  421 QDFTTFKDGQ TAMSIHVMQG ERELVQDCRS LARFALRGIP ALPAGGAHIR VTFQVDADGL 480
  481 LSVTAMEKST GVEASIQVKP SYGLTDSEIA SMIKDSMSYA EQDVKARMLA EQKVEAARVL 540
  541 ESLHGALAAD A

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 169.0
Match: 1yuwA
Description: crystal structure of bovine hsc70(aa1-554)E213A/D214A mutant
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
structural molecule activity 3.59589495899762 bayes_pls_golite062009
unfolded protein binding 2.80511977200055 bayes_pls_golite062009
binding 2.11855816699924 bayes_pls_golite062009
protein binding 2.00711904074672 bayes_pls_golite062009
carbohydrate kinase activity 1.95648644394423 bayes_pls_golite062009
transcription regulator activity 1.68670098354938 bayes_pls_golite062009
nucleic acid binding 1.43834016708999 bayes_pls_golite062009
DNA binding 1.36804228074586 bayes_pls_golite062009
transporter activity 1.2883466875237 bayes_pls_golite062009
kinase activity 1.11102445353265 bayes_pls_golite062009
hexokinase activity 1.02961928132432 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 1.00147083605664 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides 0.900931843471417 bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 0.898645342556399 bayes_pls_golite062009
pyrophosphatase activity 0.875671218597808 bayes_pls_golite062009
hydrolase activity 0.807017237368431 bayes_pls_golite062009
substrate-specific transporter activity 0.796517590178929 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.795304313835604 bayes_pls_golite062009
transcription factor activity 0.783439770973386 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.78242344952806 bayes_pls_golite062009
ATPase activity 0.687771333492666 bayes_pls_golite062009
glucose binding 0.54517877621659 bayes_pls_golite062009
cytoskeletal protein binding 0.368147081469877 bayes_pls_golite062009
catalytic activity 0.296484721581333 bayes_pls_golite062009
structural constituent of cytoskeleton 0.28741807440215 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.186218331473028 bayes_pls_golite062009
protease binding 0.168989471696885 bayes_pls_golite062009
sugar binding 0.13092093336273 bayes_pls_golite062009
transferase activity 0.105619024604158 bayes_pls_golite062009
chaperone binding 0.00111313452804307 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [552-616] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ALLSAAERQV IDDAAAHLSE VAQGDDVDAI EQAIKNVDKQ TQDFAARRMD QSVRRALKGH  60
   61 SVDEV

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 45.221849
Match: 1u00A
Description: HscA substrate binding domain complexed with the IscU recognition peptide ELPPVKIHC
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle