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View Structure Prediction Details

Protein: GLS1_ECOLI, GLSA...
Organism: Escherichia coli
Length: 310 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GLS1_ECOLI, GLSA....

Description E-value Query
Range
Subject
Range
gi|119631262 - gi|119631262|gb|EAX10857.1| glutaminase, isoform CRA_b [Homo sapiens]
gi|114582297 - gi|114582297|ref|XP_001167475.1| PREDICTED: glutaminase C isoform 3 [Pan troglodytes]
459.0 [0..3] [309..223]
gi|82878984 - gi|82878984|ref|XP_905282.1| PREDICTED: glutaminase isoform 5 [Mus musculus]
459.0 [0..3] [309..227]
gi|60654403 - gi|60654403|gb|AAX29892.1| glutaminase [synthetic construct]
458.0 [0..3] [309..222]
gi|21361452, gi|... - gi|21361452|ref|NP_055720.2| glutaminase C [Homo sapiens], gi|12044394|gb|AAG47842.1|AF327434_1 glut...
458.0 [0..3] [309..223]

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Predicted Domain #1
Region A:
Residues: [1-310]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLDANKLQQA VDQAYTQFHS LNGGQNADYI PFLANVPGQL AAVAIVTCDG NVYSAGDSDY  60
   61 RFALESISKV CTLALALEDV GPQAVQDKIG ADPTGLPFNS VIALELHGGK PLSPLVNAGA 120
  121 IATTSLINAE NVEQRWQRIL HIQQQLAGEQ VALSDEVNQS EQTTNFHNRA IAWLLYSAGY 180
  181 LYCDAMEACD VYTRQCSTLL NTIELATLGA TLAAGGVNPL THKRVLQADN VPYILAEMMM 240
  241 EGLYGRSGDW AYRVGLPGKS GVGGGILAVV PGVMGIAAFS PPLDEDGNSV RGQKMVASVA 300
  301 KQLGYNVFKG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 116.0
Match: 1u60A
Description: MCSG APC5046 Probable glutaminase ybaS
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
glutaminase activity 3.05260098857235 bayes_pls_golite062009
catalytic activity 1.85492008367309 bayes_pls_golite062009
hydrolase activity 1.71405735425066 bayes_pls_golite062009
peptidase activity 1.14979151805038 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.993155046655368 bayes_pls_golite062009
binding 0.561769858928222 bayes_pls_golite062009
serine hydrolase activity 0.0949097045108613 bayes_pls_golite062009
serine-type peptidase activity 0.0789968984744888 bayes_pls_golite062009
exopeptidase activity 0.0768852505919514 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle