YRC Public Data Repository - Protein Structure Prediction

Protein:	GADC_ECOLI
Organism:	Escherichia coli
Length:	511 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GADC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|50292087, gi\|... - gi\|50292087\|ref\|XP_448476.1\| unnamed protein product [Candida glabrata], gi\|49527788\|emb\|CAG61437.1\|... gi\|49527788 - gi\|49527788\|emb\|CAG61437.1\| unnamed protein product [Candida glabrata]	323.0	[0..4]	[501..142]
AGP1_SACBA - General amino acid permease AGP1 OS=Saccharomyces bayanus GN=AGP1 PE=3 SV=1 AGP1_SACU7 - General amino acid permease AGP1 OS=Saccharomyces uvarum (strain ATCC 76518 / CBS 7001 / CLIB 283 / ...	316.0	[0..2]	[500..114]
AGP1_YEAST - General amino acid permease AGP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AGP1 PE... AGP1 - Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, gluta...	313.0	[0..2]	[500..114]
gi\|49657519, gi\|... - gi\|50426505\|ref\|XP_461849.1\| hypothetical protein DEHA0G07579g [Debaryomyces hansenii CBS767], gi\|49...	310.0	[0..2]	[499..77]
gi\|238482071, gi... - gi\|238482071\|ref\|XP_002372274.1\| amino acid permease (Gap1), putative [Aspergillus flavus NRRL3357],... gi\|169765514 - gi\|169765514\|ref\|XP_001817228.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83765083 - gi\|83765083\|dbj\|BAE55226.1\| unnamed protein product [Aspergillus oryzae]	310.0	[0..2]	[501..76]
gi\|85095443 - gi\|85095443\|ref\|XP_960090.1\| general amino-acid permease GAP1 [Neurospora crassa OR74A] gi\|32410409, gi\|... - gi\|32410409\|ref\|XP_325685.1\| hypothetical protein [Neurospora crassa], gi\|28921549\|gb\|EAA30854.1\| ge...	309.0	[0..4]	[500..145]
gi\|39943728, gi\|... - gi\|39943728\|ref\|XP_361401.1\| hypothetical protein MG03875.4 [Magnaporthe grisea 70-15], gb\|EAA50116....	308.0	[0..3]	[507..40]

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Predicted Domain #1

Region A:
Residues: [1-511]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MATSVQTGKA KQLTLLGFFA ITASMVMAVY EYPTFATSGF SLVFFLLLGG ILWFIPVGLC  60
   61 AAEMATVDGW EEGGVFAWVS NTLGPRWGFA AISFGYLQIA IGFIPMLYFV LGALSYILKW 120
  121 PALNEDPITK TIAALIILWA LALTQFGGTK YTARIAKVGF FAGILLPAFI LIALAAIYLH 180
  181 SGAPVAIEMD SKTFFPDFSK VGTLVVFVAF ILSYMGVEAS ATHVNEMSNP GRDYPLAMLL 240
  241 LMVAAICLSS VGGLSIAMVI PGNEINLSAG VMQTFTVLMS HVAPEIEWTV RVISALLLLG 300
  301 VLAEIASWIV GPSRGMYVTA QKNLLPAAFA KMNKNGVPVT LVISQLVITS IALIILTNTG 360
  361 GGNNMSFLIA LALTVVIYLC AYFMLFIGYI VLVLKHPDLK RTFNIPGGKG VKLVVAIVGL 420
  421 LTSIMAFIVS FLPPDNIQGD STDMYVELLV VSFLVVLALP FILYAVHDRK GKANTGVTLE 480
  481 PINSQNAPKG HFFLHPRARS PHYIVMNDKK H

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.48
Match:	2a65A
Description:	Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	2.74779078524788	bayes_pls_golite062009
substrate-specific transporter activity	2.49498661846993	bayes_pls_golite062009
cation transmembrane transporter activity	2.16798643239726	bayes_pls_golite062009
ion transmembrane transporter activity	2.13565576681993	bayes_pls_golite062009
binding	0.55120193133745	bayes_pls_golite062009
transporter activity	0.13055672366183	bayes_pls_golite062009
transmembrane transporter activity	0.0150231301077546	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: