YRC Public Data Repository - Protein Structure Prediction

Protein:	FTSI_ECOLI
Organism:	Escherichia coli
Length:	588 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FTSI_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|227837840, gi... - gi\|227885011\|ref\|ZP_04002816.1\| peptidoglycan synthetase ftsI precursor [Escherichia coli 83972], gi... gi\|26106414, gi\|... - gi\|26246017\|ref\|NP_752056.1\| peptidoglycan synthetase ftsI precursor [Escherichia coli CFT073], gi\|2...	585.0	[0..1]	[588..1]
gi\|91209148, gi\|... - gi\|91209148\|ref\|YP_539134.1\| peptidoglycan synthetase FtsI precursor [Escherichia coli UTI89], gi\|91... gi\|110640297, gi... - gi\|110640297\|ref\|YP_668025.1\| peptidoglycan synthetase FtsI precursor [Escherichia coli 536], gi\|110... gi\|215485250, gi... - gi\|215485250\|ref\|YP_002327681.1\| transpeptidase involved in septal peptidoglycan synthesis (penicill... gi\|218363793, gi... - gi\|218557024\|ref\|YP_002389937.1\| transpeptidase involved in septal peptidoglycan synthesis (penicill... gi\|117622370, gi... - gi\|117622370\|ref\|YP_851283.1\| peptidoglycan synthetase FtsI precursor [Escherichia coli APEC O1], gi... gi\|226902145, gi... - gi\|237704233\|ref\|ZP_04534714.1\| peptidoglycan synthetase FtsI [Escherichia sp. 3_2_53FAA], gi\|226902...	585.0	[0..1]	[588..1]
gi\|157159555, gi... - gi\|75194301\|ref\|ZP_00704371.1\| COG0768: Cell division protein FtsI/penicillin-binding protein 2 [Esc...	584.0	[0..1]	[588..1]
gi\|56126651, gi\|... - gi\|56412394\|ref\|YP_149469.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. ente... gi\|197361330, gi... - gi\|197361330\|ref\|YP_002140965.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. ...	583.0	[0..1]	[588..1]
gi\|193070824, gi... - gi\|75234321\|ref\|ZP_00718699.1\| COG0768: Cell division protein FtsI/penicillin-binding protein 2 [Esc...	583.0	[0..1]	[588..1]
gi\|224581965, gi... - gi\|224581965\|ref\|YP_002635763.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. ... gi\|62126322, gi\|... - gi\|62178689\|ref\|YP_215106.1\| division specific transpeptidase, penicillin-binding protein 3 re [Salm... gi\|213052855 - gi\|213052855\|ref\|ZP_03345733.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. e... gi\|206707439, gi... - gi\|207855636\|ref\|YP_002242287.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. ... gi\|213647635 - gi\|213647635\|ref\|ZP_03377688.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. e... gi\|213585691 - gi\|213585691\|ref\|ZP_03367517.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. e... gi\|16418621, gi\|... - gi\|16763512\|ref\|NP_459127.1\| division specific transpeptidase [Salmonella typhimurium LT2], gi\|16418... gi\|29136291, gi\|... - gi\|29140667\|ref\|NP_804009.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. ente... gi\|25297744, gi\|... - gi\|25297744\|pir\|\|AG0517 penicillin-binding protein 3 precursor [imported] - Salmonella enterica subs... gi\|16759117 - gi\|16759117\|ref\|NP_454734.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. ente... gi\|197262017, gi... - gi\|197262017\|ref\|ZP_03162091.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica s... gi\|197213689, gi... - gi\|197249986\|ref\|YP_002145108.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica ... lcl\|NC_016856.1_... - [gene=ftsI] [protein=division specific transpeptidase] [protein_id=YP_005235781.1] [location=142438.... gi\|205271242, gi... - gi\|205351461\|ref\|YP_002225262.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. ... gi\|238911179 - gi\|238911179\|ref\|ZP_04655016.1\| penicillin-binding protein 3 precursor [Salmonella enterica subsp. e... gi\|200388309, gi... - gi\|200388309\|ref\|ZP_03214921.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica s... gi\|194450364, gi... - gi\|194450364\|ref\|YP_002044092.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica ... gi\|194446375, gi... - gi\|194446375\|ref\|YP_002039354.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica ... gi\|194734823, gi... - gi\|194734823\|ref\|YP_002113140.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica ... gi\|194457965, gi... - gi\|194471601\|ref\|ZP_03077585.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica s... gi\|205337555, gi... - gi\|205337555\|gb\|EDZ24319.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica serov... gi\|168234886, gi... - gi\|197291983\|gb\|EDY31333.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica serov... gi\|168820884, gi... - gi\|205342445\|gb\|EDZ29209.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica serov... gi\|168262193, gi... - gi\|205348668\|gb\|EDZ35299.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica serov... gi\|167550683, gi... - gi\|205324395\|gb\|EDZ12234.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica serov... gi\|168230401, gi... - gi\|205335151\|gb\|EDZ21915.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica serov... gi\|205331385, gi... - gi\|205331385\|gb\|EDZ18149.1\| peptidoglycan synthetase FtsI [Salmonella enterica subsp. enterica serov...	582.0	[0..1]	[588..1]
gi\|110613696, gi... - gi\|110804148\|ref\|YP_687668.1\| penicillin-binding protein 3; peptidoglycan synthetase [Shigella flexn...	581.0	[0..1]	[588..1]
gi\|24050287, gi\|... - gi\|24111529\|ref\|NP_706039.1\| penicillin-binding protein 3; peptidoglycan synthetase [Shigella flexne... gi\|30039893, gi\|... - gi\|30061651\|ref\|NP_835822.1\| penicillin-binding protein 3; peptidoglycan synthetase [Shigella flexne...	581.0	[0..1]	[588..1]
gi\|74310703, gi\|... - gi\|74310703\|ref\|YP_309122.1\| septum formation; penicillin-binding protein 3; peptidoglycan synthetas...	581.0	[0..1]	[588..1]
gi\|50122743, gi\|... - gi\|50122743\|ref\|YP_051910.1\| peptidoglycan synthetase [Pectobacterium atrosepticum SCRI1043], gi\|496...	571.0	[0..1]	[588..1]

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Predicted Domain #1

Region A:
Residues: [1-588]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKAAAKTQKP KRQEEHANFI SWRFALLCGC ILLALAFLLG RVAWLQVISP DMLVKEGDMR  60
   61 SLRVQQVSTS RGMITDRSGR PLAVSVPVKA IWADPKEVHD AGGISVGDRW KALANALNIP 120
  121 LDQLSARINA NPKGRFIYLA RQVNPDMADY IKKLKLPGIH LREESRRYYP SGEVTAHLIG 180
  181 FTNVDSQGIE GVEKSFDKWL TGQPGERIVR KDRYGRVIED ISSTDSQAAH NLALSIDERL 240
  241 QALVYRELNN AVAFNKAESG SAVLVDVNTG EVLAMANSPS YNPNNLSGTP KEAMRNRTIT 300
  301 DVFEPGSTVK PMVVMTALQR GVVRENSVLN TIPYRINGHE IKDVARYSEL TLTGVLQKSS 360
  361 NVGVSKLALA MPSSALVDTY SRFGLGKATN LGLVGERSGL YPQKQRWSDI ERATFSFGYG 420
  421 LMVTPLQLAR VYATIGSYGI YRPLSITKVD PPVPGERVFP ESIVRTVVHM MESVALPGGG 480
  481 GVKAAIKGYR IAIKTGTAKK VGPDGRYINK YIAYTAGVAP ASQPRFALVV VINDPQAGKY 540
  541 YGGAVSAPVF GAIMGGVLRT MNIEPDALTT GDKNEFVINQ GEGTGGRS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	102.0
Match:	1rp5A
Description:	PBP2x from Streptococcus pneumoniae strain 5259 with reduced susceptibility to beta-lactam antibiotics
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
serine-type D-Ala-D-Ala carboxypeptidase activity	3.12650314537616	bayes_pls_golite062009
serine-type carboxypeptidase activity	2.70174066798582	bayes_pls_golite062009
serine-type exopeptidase activity	2.69091897402517	bayes_pls_golite062009
drug binding	2.00030594135732	bayes_pls_golite062009
carboxypeptidase activity	1.96547160092829	bayes_pls_golite062009
penicillin binding	1.46269268256076	bayes_pls_golite062009
exopeptidase activity	1.44522375970439	bayes_pls_golite062009
binding	1.43165609051179	bayes_pls_golite062009
catalytic activity	0.767627914425245	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	0.163657050466595	bayes_pls_golite062009
protein binding	0.0666688846338231	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: