YRC Public Data Repository - Protein Structure Prediction

Protein:	FKBA_ECOLI
Organism:	Escherichia coli
Length:	270 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FKBA_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|110616728, gi... - gi\|110807180\|ref\|YP_690700.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Shigella flexneri 5 str... gi\|24053810, gi\|... - gi\|24114611\|ref\|NP_709121.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Shigella flexneri 2a str... gi\|30065367, gi\|... - gi\|30065367\|ref\|NP_839538.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Shigella flexneri 2a str...	211.0	[0..1]	[259..1]
gi\|209756942, gi... - pir\|\|F91153 FKBP-type peptidyl-prolyl cis-trans isomerase [imported] - Escherichia coli (strain O157... FKBA_ECOL6 - FKBP-type peptidyl-prolyl cis-trans isomerase FkpA OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 7... gi\|168753103, gi... - gi\|189359191\|gb\|EDU77610.1\| FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [Escherichia coli O15... gi\|188014187, gi... - gi\|188014187\|gb\|EDU52309.1\| FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [Escherichia coli O15... gi\|218697026, gi... - gi\|218697026\|ref\|YP_002404693.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli 559... gi\|218560408, gi... - gi\|218560408\|ref\|YP_002393321.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli S88... gi\|91212823, gi\|... - gi\|91212823\|ref\|YP_542809.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli UTI89],... gi\|218706941, gi... - gi\|218706941\|ref\|YP_002414460.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli UMN... gi\|13363671, gi\|... - gi\|15833452\|ref\|NP_312225.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli O157:H7... gi\|218702095, gi... - gi\|218702095\|ref\|YP_002409724.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli IAI... gi\|193061860, gi... - gi\|75260363\|ref\|ZP_00731631.1\| COG0545: FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Escherichi... gi\|188493036, gi... - gi\|188493036\|ref\|ZP_03000306.1\| FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [Escherichia coli... gi\|74313853, gi\|... - gi\|74313853\|ref\|YP_312272.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Shigella sonnei Ss046], ... gi\|170680696, gi... - gi\|170680696\|ref\|YP_001745595.1\| FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [Escherichia col... gi\|194430698, gi... - gi\|75207903\|ref\|ZP_00708356.1\| COG0545: FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Escherichi... gi\|208814429, gi... - gi\|208814429\|ref\|ZP_03255758.1\| FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [Escherichia coli... gi\|191171482, gi... - gi\|75241558\|ref\|ZP_00725403.1\| COG0545: FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Escherichi... gi\|195934843 - gi\|195934843\|ref\|ZP_03080225.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli O157... FKBA_ECOL6 - FKBP-type peptidyl-prolyl cis-trans isomerase fkpA OS=Escherichia coli O6 GN=fkpA PE=3 SV=1 gi\|209914058, gi... - gi\|209920799\|ref\|YP_002294883.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli SE1... FKBA_ECO57 - FKBP-type peptidyl-prolyl cis-trans isomerase FkpA OS=Escherichia coli O157:H7 GN=fkpA PE=3 SV=1 gi\|209397438, gi... - gi\|209397438\|ref\|YP_002272789.1\| FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [Escherichia col... gi\|81247107, gi\|... - gi\|82545696\|ref\|YP_409643.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Shigella boydii Sb227], ... gi\|218555891, gi... - gi\|218555891\|ref\|YP_002388804.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli IAI... gi\|217320648, gi... - gi\|217324427\|ref\|ZP_03440511.1\| FKBP-type peptidyl-prolyl cis-trans isomerase FkpA [Escherichia coli... gi\|157157129, gi... - gi\|75188122\|ref\|ZP_00701389.1\| COG0545: FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Escherichi... gi\|157162823, gi... - gi\|75197279\|ref\|ZP_00707349.1\| COG0545: FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Escherichi... gi\|115514749, gi... - gi\|117625625\|ref\|YP_858948.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli APEC O... gi\|227883481, gi... - gi\|227883481\|ref\|ZP_04001286.1\| peptidylprolyl isomerase [Escherichia coli 83972], gi\|227839360\|gb\|E... gi\|226902342, gi... - gi\|237703078\|ref\|ZP_04533559.1\| peptidyl-prolyl cis-trans isomerase fkpA [Escherichia sp. 3_2_53FAA]... gi\|242378873, gi... - gi\|251786600\|ref\|YP_003000904.1\| hypothetical protein B21_03149 [Escherichia coli BL21], gi\|24237887... gi\|254290025, gi... - gi\|254290025\|ref\|YP_003055773.1\| FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) [Escherich... gi\|254163275, gi... - gi\|254163275\|ref\|YP_003046383.1\| FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) [Escherich... gi\|254594670, gi... - gi\|254795270\|ref\|YP_003080107.1\| FKBP-type peptidyl-prolyl cis-trans isomerase (rotamase) [Escherich...	211.0	[0..1]	[259..1]
gi\|187428304, gi... - gi\|75180040\|ref\|ZP_00700027.1\| COG0545: FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Shigella b...	211.0	[0..1]	[259..1]
gi\|12517968, gi\|... - gi\|15803860\|ref\|NP_289894.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli O157:H7... gi\|25358304 - gi\|25358304\|pir\|\|B85999 hypothetical protein fkpA [imported] - Escherichia coli (strain O157:H7, su...	208.0	[0..1]	[259..1]
gi\|110643588, gi... - gi\|110643588\|ref\|YP_671318.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Escherichia coli 536], ...	208.0	[0..1]	[259..1]
gi\|82778628, gi\|... - gi\|82778628\|ref\|YP_404977.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Shigella dysenteriae Sd1...	206.0	[0..1]	[248..1]
gi\|27364730, gi\|... - gi\|27364730\|ref\|NP_760258.1\| FKBP-type peptidyl-prolyl cis-trans isomerase 1 [Vibrio vulnificus CMCP...	206.0	[0..1]	[252..1]
gi\|37199972, gi\|... - gi\|37681221\|ref\|NP_935830.1\| FKBP-type peptidyl-prolyl cis-trans isomerase 1 [Vibrio vulnificus YJ01...	206.0	[0..1]	[252..5]
gi\|238722947, gi... - gi\|77975000\|ref\|ZP_00830537.1\| COG0545: FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Yersinia f...	205.0	[0..1]	[253..5]
gi\|25358305, gi\|... - gi\|25358305\|pir\|\|AD1004 peptidylprolyl isomerase (EC 5.2.1.8) - Salmonella enterica subsp. enterica ... gi\|29144317, gi\|... - gi\|29144317\|ref\|NP_807659.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Salmonella enterica subs... gi\|213416478 - gi\|213416478\|ref\|ZP_03349622.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Salmonella enterica s... gi\|213163704 - gi\|213163704\|ref\|ZP_03349414.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Salmonella enterica s... gi\|16762830 - gi\|16762830\|ref\|NP_458447.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Salmonella enterica subs... gi\|213865465 - gi\|213865465\|ref\|ZP_03387584.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Salmonella enterica s... gi\|213649025 - gi\|213649025\|ref\|ZP_03379078.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Salmonella enterica s... gi\|213608031 - gi\|213608031\|ref\|ZP_03368857.1\| FKBP-type peptidyl-prolyl cis-trans isomerase [Salmonella enterica s...	204.0	[0..1]	[248..1]

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Predicted Domain #1

Region A:
Residues: [1-270]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKSLFKVTLL ATTMAVALHA PITFAAEAAK PATAADSKAA FKNDDQKSAY ALGASLGRYM  60
   61 ENSLKEQEKL GIKLDKDQLI AGVQDAFADK SKLSDQEIEQ TLQAFEARVK SSAQAKMEKD 120
  121 AADNEAKGKE YREKFAKEKG VKTSSTGLVY QVVEAGKGEA PKDSDTVVVN YKGTLIDGKE 180
  181 FDNSYTRGEP LSFRLDGVIP GWTEGLKNIK KGGKIKLVIP PELAYGKAGV PGIPPNSTLV 240
  241 FDVELLDVKP APKADAKPEA DAKAADSAKK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	44.522879
Match:	1q6uA
Description:	Crystal structure of FkpA from Escherichia coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ryanodine-sensitive calcium-release channel activity	10.9968443145942	bayes_pls_golite062009
intracellular ligand-gated calcium channel activity	10.9968443145942	bayes_pls_golite062009
macrolide binding	7.31599503004442	bayes_pls_golite062009
FK506 binding	7.22442625476031	bayes_pls_golite062009
metal ion transmembrane transporter activity	6.74926751944787	bayes_pls_golite062009
calcium channel activity	6.4374377859142	bayes_pls_golite062009
cation channel activity	6.06732269872248	bayes_pls_golite062009
ion channel activity	5.45007096522107	bayes_pls_golite062009
passive transmembrane transporter activity	5.32426176964634	bayes_pls_golite062009
channel activity	5.32426176964634	bayes_pls_golite062009
substrate-specific channel activity	5.28960420749143	bayes_pls_golite062009
gated channel activity	5.28074654906904	bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity	4.0615867467963	bayes_pls_golite062009
cis-trans isomerase activity	3.99265212272703	bayes_pls_golite062009
ligand-gated channel activity	3.34717828007833	bayes_pls_golite062009
ligand-gated ion channel activity	3.34717828007833	bayes_pls_golite062009
ion transmembrane transporter activity	2.6566793500337	bayes_pls_golite062009
cation transmembrane transporter activity	2.61794461605199	bayes_pls_golite062009
calcium-release channel activity	2.58969194870156	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.47257819150887	bayes_pls_golite062009
isomerase activity	2.31710030777753	bayes_pls_golite062009
transcription regulator activity	1.85589011277711	bayes_pls_golite062009
receptor activity	1.78361575899771	bayes_pls_golite062009
transmembrane receptor activity	1.7459556028988	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	1.68688812199737	bayes_pls_golite062009
kinase activity	1.67904764195462	bayes_pls_golite062009
binding	1.63170667962375	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	1.57898291235576	bayes_pls_golite062009
signal transducer activity	1.53711974553033	bayes_pls_golite062009
molecular transducer activity	1.53711974553033	bayes_pls_golite062009
protein kinase activity	1.45320632553313	bayes_pls_golite062009
drug binding	1.39643621593407	bayes_pls_golite062009
transferase activity	1.34122735969662	bayes_pls_golite062009
receptor serine/threonine kinase binding	1.32709321745178	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding	1.32470025150272	bayes_pls_golite062009
transforming growth factor beta receptor binding	1.32470025150272	bayes_pls_golite062009
transporter activity	1.25197125648774	bayes_pls_golite062009
protein binding	1.08765413491791	bayes_pls_golite062009
SMAD binding	1.04905381164355	bayes_pls_golite062009
transmembrane transporter activity	1.03909235910355	bayes_pls_golite062009
catalytic activity	0.885282592863018	bayes_pls_golite062009
substrate-specific transporter activity	0.789390402522536	bayes_pls_golite062009
transmembrane receptor protein kinase activity	0.780499202755666	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	0.763739321802433	bayes_pls_golite062009
transforming growth factor beta receptor activity	0.763739321802433	bayes_pls_golite062009
intracellular ligand-gated ion channel activity	0.727019445105701	bayes_pls_golite062009
protein serine/threonine kinase activity	0.671059013500415	bayes_pls_golite062009
activin binding	0.33489895389042	bayes_pls_golite062009
unfolded protein binding	0.27473817613726	bayes_pls_golite062009
transcription elongation regulator activity	0.0778721788337902	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: