YRC Public Data Repository - Protein Structure Prediction

Protein:	DPIB_ECOLI
Organism:	Escherichia coli
Length:	552 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPIB_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|124499344, gi... - gi\|124530181\|ref\|ZP_01700930.1\| signal transduction histidine kinase regulating citrate/malate metab... gi\|169755950, gi... - gi\|170021022\|ref\|YP_001725976.1\| signal transduction histidine kinase regulating citrate/malate meta... gi\|83570450, gi\|... - gi\|83570450\|ref\|ZP_00921895.1\| COG3290: Signal transduction histidine kinase regulating citrate/mala...	297.0	[0..1]	[552..1]
gi\|83586946, gi\|... - gi\|83586946\|ref\|ZP_00925576.1\| COG3290: Signal transduction histidine kinase regulating citrate/mala... gi\|218694060, gi... - gi\|218694060\|ref\|YP_002401727.1\| sensory histidine kinase in two-component regulatory system with ci... gi\|75258644, gi\|... - gi\|75258644\|ref\|ZP_00730051.1\| COG3290: Signal transduction histidine kinase regulating citrate/mala... gi\|75229496, gi\|... - gi\|75229496\|ref\|ZP_00716043.1\| COG3290: Signal transduction histidine kinase regulating citrate/mala... gi\|209917878, gi... - gi\|209917878\|ref\|YP_002291962.1\| two-component sensor kinase [Escherichia coli SE11], gi\|209911137\|d... gi\|75210753, gi\|... - gi\|75210753\|ref\|ZP_00710885.1\| COG3290: Signal transduction histidine kinase regulating citrate/mala... gi\|218359930, gi... - gi\|218553162\|ref\|YP_002386075.1\| sensory histidine kinase in two-component regulatory system with ci... gi\|157157319, gi... - gi\|75189658\|ref\|ZP_00702925.1\| COG3290: Signal transduction histidine kinase regulating citrate/mala... gi\|209777258, gi... - gi\|209777264\|gb\|ACI86944.1\| putative sensor-type protein [Escherichia coli], gi\|209777258\|gb\|ACI8694...	296.0	[0..1]	[552..1]
gi\|190907379, gi... - gi\|75240775\|ref\|ZP_00724682.1\| COG3290: Signal transduction histidine kinase regulating citrate/mala... gi\|218426007, gi... - gi\|218688443\|ref\|YP_002396655.1\| sensory histidine kinase in two-component regulatory system with ci... gi\|110640849, gi... - gi\|110640849\|ref\|YP_668577.1\| sensor kinase DpiB [Escherichia coli 536], gi\|110342441\|gb\|ABG68678.1\|...	296.0	[0..1]	[552..1]
gi\|75236601, gi\|... - gi\|75236601\|ref\|ZP_00720689.1\| COG3290: Signal transduction histidine kinase regulating citrate/mala...	296.0	[0..1]	[552..1]
gi\|26246600, gi\|... - gi\|26246600\|ref\|NP_752639.1\| sensor kinase dpiB [Escherichia coli CFT073], gi\|26106999\|gb\|AAN79183.1...	296.0	[0..1]	[552..21]
gi\|209398542, gi... - gi\|209398542\|ref\|YP_002269255.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC4115]... gi\|208823051, gi... - gi\|208823051\|ref\|ZP_03263369.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC4042],... gi\|208815854, gi... - gi\|208815854\|ref\|ZP_03257033.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC4045],... gi\|254791786, gi... - gi\|254791786\|ref\|YP_003076623.1\| sensory histidine kinase in two-component regulatory system with ci... gi\|208727472, gi... - gi\|208807671\|ref\|ZP_03250008.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC4206],... gi\|217322265, gi... - gi\|217326044\|ref\|ZP_03442128.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. TW14588]... gi\|187769798, gi... - gi\|187769798\|gb\|EDU33642.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC4196], gi\|... gi\|168760231, gi... - gi\|189369152\|gb\|EDU87568.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC4501], gi\|... gi\|25298485, gi\|... - pir\|\|F85561 probable sensor-type protein citA [imported] - Escherichia coli (strain O157:H7, substra... gi\|189358058, gi... - gi\|189358058\|gb\|EDU76477.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC4401], gi\|... gi\|168747710, gi... - gi\|188017702\|gb\|EDU55824.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC4113], gi\|... gi\|12513518, gi\|... - gi\|15800334\|ref\|NP_286346.1\| putative sensor-type protein [Escherichia coli O157:H7 EDL933], gi\|1251... gi\|195936169 - gi\|195936169\|ref\|ZP_03081551.1\| putative sensor-type protein [Escherichia coli O157:H7 str. EC4024] gi\|13360116, gi\|... - gi\|15829912\|ref\|NP_308685.1\| putative sensor-type protein [Escherichia coli O157:H7], gi\|13360116\|db... gi\|189379234, gi... - gi\|189379234\|gb\|EDU97650.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC508], gi\|1... gi\|168786467, gi... - gi\|189373705\|gb\|EDU92121.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC869], gi\|1... gi\|189002723, gi... - gi\|189002723\|gb\|EDU71709.1\| sensor histidine kinase DpiB [Escherichia coli O157:H7 str. EC4076], gi\|... gi\|13360116, gi\|... - gi\|15829912\|ref\|NP_308685.1\| putative sensor-type protein [Escherichia coli O157:H7 str. Sakai], gi\|...	295.0	[0..1]	[552..1]
gi\|157160115, gi... - gi\|75194803\|ref\|ZP_00704873.1\| COG3290: Signal transduction histidine kinase regulating citrate/mala...	295.0	[0..1]	[552..1]
gi\|218364328, gi... - gi\|218557559\|ref\|YP_002390472.1\| sensory histidine kinase in two-component regulatory system with ci... gi\|117622838, gi... - gi\|117622838\|ref\|YP_851751.1\| sensor kinase DpiB [Escherichia coli APEC O1], gi\|115511962\|gb\|ABJ0003...	295.0	[0..1]	[552..1]
gi\|73854631, gi\|... - gi\|74311154\|ref\|YP_309573.1\| putative sensor-type protein [Shigella sonnei Ss046], gi\|73854631\|gb\|AA...	294.0	[0..1]	[552..1]
gi\|91209668, gi\|... - gi\|91209668\|ref\|YP_539654.1\| sensor kinase DpiB [Escherichia coli UTI89], gi\|91071242\|gb\|ABE06123.1\|... gi\|237707408, gi... - gi\|237707408\|ref\|ZP_04537889.1\| sensor kinase DpiB [Escherichia sp. 3_2_53FAA], gi\|226898618\|gb\|EEH8...	294.0	[0..1]	[552..21]

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Predicted Domain #1

Region A:
Residues: [1-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLQLNENKQF AFFQRLAFPL RIFLLILVFS IFVIAALAQY FTASFEDYLT LHVRDMAMNQ  60
   61 AKIIASNDSV ISAVKTRDYK RLATIANKLQ RDTDFDYVVI GDRHSIRLYH PNPEKIGYPM 120
  121 QFTKQGALEK GESYFITGKG SMGMAMRAKT PIFDDDGKVI GVVSIGYLVS KIDSWRAEFL 180
  181 LPMAGVFVVL LGILMLLS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	4.0
Match:	1p0zA
Description:	Sensor Kinase CitA binding domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component sensor activity	2.88093868237858	bayes_pls_golite062009
protein histidine kinase activity	2.86151216540335	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.80671328721504	bayes_pls_golite062009
two-component response regulator activity	1.62873572477094	bayes_pls_golite062009
signal transducer activity	1.10204821596482	bayes_pls_golite062009
molecular transducer activity	1.10204821596482	bayes_pls_golite062009
binding	0.704248066961418	bayes_pls_golite062009
protein kinase activity	0.510808146850279	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.399812011068743	bayes_pls_golite062009
kinase activity	0.223004824807113	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0995264574132551	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [199-324]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WFLAAHIRRQ MMGMEPKQIA RVVRQQEALF SSVYEGLIAV DPHGYITAIN RNARKMLGLS  60
   61 SPGRQWLGKP IVEVVRPADF FTEQIDEKRQ DVVANFNGLS VIANREAIRS GDDLLGAIIS 120
  121 FRSKDE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	5.045757
Match:	1y28A
Description:	Crystal structure of the R220A metBJFIXL HEME domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	1.79230776794479	bayes_pls_golite062009
two-component response regulator activity	1.45691562840107	bayes_pls_golite062009
transcription regulator activity	1.13913685347546	bayes_pls_golite062009
protein binding	1.0133195984081	bayes_pls_golite062009
DNA binding	0.73243452463464	bayes_pls_golite062009
two-component sensor activity	0.58151911764083	bayes_pls_golite062009
protein histidine kinase activity	0.56538125817883	bayes_pls_golite062009
nucleic acid binding	0.5545839402512	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	0.518111391350209	bayes_pls_golite062009
signal transducer activity	0.441034662376355	bayes_pls_golite062009
molecular transducer activity	0.441034662376355	bayes_pls_golite062009
transcription factor activity	0.36759096137141	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [325-552]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ISTLNAQLTQ IKQYVESLRT LRHEHLNWMS TLNGLLQMKE YDRVLAMVQG ESQAQQQLID  60
   61 SLREAFADRQ VAGLLFGKVQ RARELGLKMI IVPGSQLSQL PPGLDSTEFA AIVGNLLDNA 120
  121 FEASLRSDEG NKIVELFLSD EGDDVVIEVA DQGCGVPESL RDKIFEQGVS TRADEPGEHG 180
  181 IGLYLIASYV TRCGGVITLE DNDPCGTLFS IYIPKVKPND SSINPIDR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	41.0
Match:	2c2aA
Description:	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: