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View Structure Prediction Details

Protein: CLCA_ECOLI
Organism: Escherichia coli
Length: 473 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CLCA_ECOLI.

Description E-value Query
Range
Subject
Range
gi|50745842 - gi|50745842|ref|XP_420265.1| PREDICTED: similar to chloride channel CLC-5 [Gallus gallus]
351.0 [0..2] [466..936]
gi|119625190, gi... - gi|55770840|ref|NP_776297.2| chloride channel 3 isoform e [Homo sapiens], gi|119625190|gb|EAX04785.1...
gi|114596816 - gi|114596816|ref|XP_001153846.1| PREDICTED: chloride channel 3 isoform 3 [Pan troglodytes]
349.0 [0..2] [470..95]
gi|74177944, gi|... - gi|74177944|dbj|BAE29767.1| unnamed protein product [Mus musculus], gi|74141979|dbj|BAE41053.1| unna...
349.0 [0..2] [470..95]
gi|74006439 - gi|74006439|ref|XP_856009.1| PREDICTED: similar to Chloride channel protein 4 (ClC-4) isoform 3 [Can...
348.0 [0..1] [466..36]
gi|220061722, gi... - gi|47210785|emb|CAF91095.1| unnamed protein product [Tetraodon nigroviridis], gi|220061722|gb|ACL795...
348.0 [0..2] [471..72]
gi|114596822 - gi|114596822|ref|XP_001154032.1| PREDICTED: similar to chloride channel 3 isoform 6 [Pan troglodytes...
346.0 [0..2] [470..68]

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Predicted Domain #1
Region A:
Residues: [1-473]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKTDTPSLET PQAARLRRRQ LIRQLLERDK TPLAILFMAA VVGTLVGLAA VAFDKGVAWL  60
   61 QNQRMGALVH TADNYPLLLT VAFLCSAVLA MFGYFLVRKY APEAGGSGIP EIEGALEDQR 120
  121 PVRWWRVLPV KFFGGLGTLG GGMVLGREGP TVQIGGNIGR MVLDIFRLKG DEARHTLLAT 180
  181 GAAAGLAAAF NAPLAGILFI IEEMRPQFRY TLISIKAVFI GVIMSTIMYR IFNHEVALID 240
  241 VGKLSDAPLN TLWLYLILGI IFGIFGPIFN KWVLGMQDLL HRVHGGNITK WVLMGGAIGG 300
  301 LCGLLGFVAP ATSGGGFNLI PIATAGNFSM GMLVFIFVAR VITTLLCFSS GAPGGIFAPM 360
  361 LALGTVLGTA FGMVAVELFP QYHLEAGTFA IAGMGALLAA SIRAPLTGII LVLEMTDNYQ 420
  421 LILPMIITGL GATLLAQFTG GKPLYSAILA RTLAKQEAEQ LARSKAASAS ENT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 80.69897
Match: 1kplA
Description: Clc chloride channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
anion channel activity 5.23649338477108 bayes_pls_golite062009
chloride channel activity 5.23649338477108 bayes_pls_golite062009
anion transmembrane transporter activity 4.7823647688311 bayes_pls_golite062009
voltage-gated chloride channel activity 4.66898411574669 bayes_pls_golite062009
voltage-gated anion channel activity 4.66898411574669 bayes_pls_golite062009
ion transmembrane transporter activity 3.29532156100584 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.9211909958998 bayes_pls_golite062009
ion channel activity 2.47371003999085 bayes_pls_golite062009
substrate-specific channel activity 2.3506930471942 bayes_pls_golite062009
channel activity 2.34190943501298 bayes_pls_golite062009
passive transmembrane transporter activity 2.34190943501298 bayes_pls_golite062009
voltage-gated ion channel activity 1.83450427449366 bayes_pls_golite062009
voltage-gated channel activity 1.82456160587504 bayes_pls_golite062009
gated channel activity 1.60884925346186 bayes_pls_golite062009
transporter activity 1.42882449395305 bayes_pls_golite062009
transmembrane transporter activity 1.27364043073575 bayes_pls_golite062009
substrate-specific transporter activity 1.11689211993777 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle