YRC Public Data Repository - Protein Structure Prediction

Protein:	ARAE_ECOLI
Organism:	Escherichia coli
Length:	472 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ARAE_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|91078244 - gi\|91078244\|ref\|XP_970364.1\| PREDICTED: similar to CG10960-PB, isoform B [Tribolium castaneum]	319.0	[0..22]	[467..688]
gi\|49527412 - gi\|49527412\|emb\|CAG61052.1\| unnamed protein product [Candida glabrata] gi\|50291337, gi\|... - gi\|50291337\|ref\|XP_448101.1\| unnamed protein product [Candida glabrata], gi\|49527412\|emb\|CAG61052.1\|...	316.0	[0..1]	[463..97]
gi\|125807904, gi... - gi\|54635731\|gb\|EAL25134.1\| GA15593-PA [Drosophila pseudoobscura], gi\|125807904\|ref\|XP_001360559.1\| G...	308.0	[0..12]	[466..387]
gi\|42555201, gi\|... - gi\|46126945\|ref\|XP_388026.1\| hypothetical protein FG07850.1 [Gibberella zeae PH-1], gi\|42555201\|gb\|E...	301.0	[0..3]	[463..1499]
CG30035-PA - This gene is referred to in FlyBase by the symbol Dmel\CG30035 (CG30035, FBgn0050035). It is a prote...	301.0	[0..12]	[466..386]
gi\|90307566, gi\|... - gi\|90307566\|gb\|EAS37197.1\| hypothetical protein CIMG_02551 [Coccidioides immitis RS], gi\|119196353\|r...	299.0	[0..9]	[463..239]
TRET1_AEDAE - Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1	299.0	[0..12]	[466..335]
SNF3 - Plasma membrane low glucose sensor that regulates glucose transport; contains 12 predicted transmemb... SNF3_YEAST - High-affinity glucose transporter SNF3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=S...	298.0	[0..1]	[461..67]
gi\|115402325, gi... - gi\|115402325\|ref\|XP_001217239.1\| hypothetical protein ATEG_08653 [Aspergillus terreus NIH2624], gi\|1...	295.0	[0..16]	[470..43]
gi\|169764102 - gi\|169764102\|ref\|XP_001727951.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83770979 - gi\|83770979\|dbj\|BAE61112.1\| unnamed protein product [Aspergillus oryzae]	291.0	[0..1]	[463..192]

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Predicted Domain #1

Region A:
Residues: [1-472]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVTINTESAL TPRSLRDTRR MNMFVSVAAA VAGLLFGLDI GVIAGALPFI TDHFVLTSRL  60
   61 QEWVVSSMML GAAIGALFNG WLSFRLGRKY SLMAGAILFV LGSIGSAFAT SVEMLIAARV 120
  121 VLGIAVGIAS YTAPLYLSEM ASENVRGKMI SMYQLMVTLG IVLAFLSDTA FSYSGNWRAM 180
  181 LGVLALPAVL LIILVVFLPN SPRWLAEKGR HIEAEEVLRM LRDTSEKARE ELNEIRESLK 240
  241 LKQGGWALFK INRNVRRAVF LGMLLQAMQQ FTGMNIIMYY APRIFKMAGF TTTEQQMIAT 300
  301 LVVGLTFMFA TFIAVFTVDK AGRKPALKIG FSVMALGTLV LGYCLMQFDN GTASSGLSWL 360
  361 SVGMTMMCIA GYAMSAAPVV WILCSEIQPL KCRDFGITCS TTTNWVSNMI IGATFLTLLD 420
  421 SIGAAGTFWL YTALNIAFVG ITFWLIPETK NVTLEHIERK LMAGEKLRNI GV

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	30.045757
Match:	1pw4A
Description:	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
alcohol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
polyol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
glycerol transmembrane transporter activity	6.54968363274124	bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity	5.40344495119017	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	3.29248638217469	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	3.29248638217469	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
binding	1.89539096965643	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	1.6904339767429	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: