YRC Public Data Repository - Protein Structure Prediction

Protein:	AQPZ_ECOLI
Organism:	Escherichia coli
Length:	231 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for AQPZ_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|69111664 - gi\|69111664\|gb\|AAZ03394.1\| Aqp4-Luc fusion protein [Reporter vector pmuAqp4-Luc]	218.0	[0..2]	[230..13]
gi\|69111702 - gi\|69111702\|gb\|AAZ03395.1\| Aqp4-Luc fusion protein [Reporter vector praAqp4-Luc]	214.0	[0..2]	[230..13]
gi\|115459788, gi... - gi\|50927737\|ref\|XP_473424.1\| OSJNBb0034G17.15 [Oryza sativa (japonica cultivar-group)], gi\|38605857\|...	205.0	[0..2]	[227..18]
gi\|94399989 - gi\|94399989\|ref\|XP_001003734.1\| PREDICTED: similar to aquaporin 5 [Mus musculus]	205.0	[0..2]	[229..165]
gi\|73961781 - gi\|73961781\|ref\|XP_855456.1\| PREDICTED: similar to Aquaporin 4 (WCH4) (Mercurial-insensitive water c...	202.0	[0..2]	[230..110]
gi\|151944919 - gi\|151944919\|gb\|EDN63174.1\| conserved protein [Saccharomyces cerevisiae YJM789] YFL054C - Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the prese... YFF4_YEAST - Uncharacterized membrane protein YFL054C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN...	201.0	[0..2]	[205..347]
gi\|18481673 - gi\|18481673\|gb\|AAL73511.1\|AF465730_1 aquaporin-4 [Coturnix coturnix]	199.0	[0..2]	[230..47]
gi\|52345956, gi\|... - gi\|52345956\|ref\|NP_001004765.1\| aquaporin 4 [Gallus gallus], gi\|52138496\|dbj\|BAD46731.1\| aquaporin 4...	197.0	[0..2]	[230..47]
gi\|255646628 - gi\|255646628\|gb\|ACU23788.1\| unknown [Glycine max] PIP27_MAIZE - Aquaporin PIP2-7 OS=Zea mays GN=PIP2-7 PE=2 SV=1	197.0	[0..1]	[228..38]
gi\|62546339 - gi\|62546339\|gb\|AAX86046.1\| PIP2,2 [Glycine max]	196.0	[0..1]	[228..38]

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Predicted Domain #1

Region A:
Residues: [1-231]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFRKLAAECF GTFWLVFGGC GSAVLAAGFP ELGIGFAGVA LAFGLTVLTM AFAVGHISGG  60
   61 HFNPAVTIGL WAGGRFPAKE VVGYVIAQVV GGIVAAALLY LIASGKTGFD AAASGFASNG 120
  121 YGEHSPGGYS MLSALVVELV LSAGFLLVIH GATDKFAPAG FAPIAIGLAL TLIHLISIPV 180
  181 TNTSVNPARS TAVAIFQGGW ALEQLWFFWV VPIVGGIIGG LIYRTLLEKR D

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.09691
Match:	1rc2B
Description:	2.5 Angstrom Resolution X-ray Structure of Aquaporin Z
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
water transmembrane transporter activity	9.67908250471459	bayes_pls_golite062009
water channel activity	9.56962566441621	bayes_pls_golite062009
transporter activity	5.23077472964938	bayes_pls_golite062009
transmembrane transporter activity	4.83314424546299	bayes_pls_golite062009
substrate-specific transporter activity	4.81038646091786	bayes_pls_golite062009
channel activity	4.07325022774195	bayes_pls_golite062009
passive transmembrane transporter activity	4.07325022774195	bayes_pls_golite062009
substrate-specific channel activity	4.06232743056	bayes_pls_golite062009
glycerol channel activity	3.87882884469974	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.579516223912	bayes_pls_golite062009
pyrimidine transmembrane transporter activity	1.71827601616207	bayes_pls_golite062009
nucleobase transmembrane transporter activity	1.38222966724035	bayes_pls_golite062009
purine transmembrane transporter activity	1.38222966724035	bayes_pls_golite062009
binding	0.880990983024834	bayes_pls_golite062009
polyol transmembrane transporter activity	0.820388351311438	bayes_pls_golite062009
alcohol transmembrane transporter activity	0.820388351311438	bayes_pls_golite062009
glycerol transmembrane transporter activity	0.545299611300918	bayes_pls_golite062009
active transmembrane transporter activity	0.315342449421593	bayes_pls_golite062009
ion transmembrane transporter activity	0.244345278509118	bayes_pls_golite062009
protein binding	0.179478120921785	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: