YRC Public Data Repository - Protein Structure Prediction

Protein:	ADIC_ECOLI
Organism:	Escherichia coli
Length:	445 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ADIC_ECOLI.

Description	E-value	Query Range	Subject Range
gi\|68373624 - gi\|68373624\|ref\|XP_692242.1\| PREDICTED: similar to Cationic amino acid transporter 3 (CAT-3) (Solute...	297.0	[0..3]	[378..970]
gi\|42548077, gi\|... - gi\|46115934\|ref\|XP_383985.1\| hypothetical protein FG03809.1 [Gibberella zeae PH-1], gi\|42548077\|gb\|E...	269.0	[0..2]	[437..1097]
gi\|85095443 - gi\|85095443\|ref\|XP_960090.1\| general amino-acid permease GAP1 [Neurospora crassa OR74A] gi\|32410409, gi\|... - gi\|32410409\|ref\|XP_325685.1\| hypothetical protein [Neurospora crassa], gi\|28921549\|gb\|EAA30854.1\| ge...	269.0	[0..6]	[444..145]
gi\|238482071, gi... - gi\|238482071\|ref\|XP_002372274.1\| amino acid permease (Gap1), putative [Aspergillus flavus NRRL3357],... gi\|169765514 - gi\|169765514\|ref\|XP_001817228.1\| hypothetical protein [Aspergillus oryzae RIB40] gi\|83765083 - gi\|83765083\|dbj\|BAE55226.1\| unnamed protein product [Aspergillus oryzae]	267.0	[0..2]	[438..74]
gi\|116181860, gi... - gi\|88185855\|gb\|EAQ93323.1\| hypothetical protein CHGG_01558 [Chaetomium globosum CBS 148.51], gi\|1161...	266.0	[0..2]	[411..105]
gi\|49647803, gi\|... - gi\|50548931\|ref\|XP_501936.1\| YALI0C17237p [Yarrowia lipolytica], gi\|49647803\|emb\|CAG82256.1\| unnamed... gi\|49647803 - gi\|49647803\|emb\|CAG82256.1\| YALI0C17237p [Yarrowia lipolytica]	266.0	[0..2]	[445..102]
YI26_SCHPO - Uncharacterized amino-acid permease P7G5.06 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) G... SPAP7G5.06 - amino acid permease, unknown 4	265.0	[0..6]	[439..80]
gi\|91084137 - gi\|91084137\|ref\|XP_969912.1\| PREDICTED: similar to CG8475-PA, isoform A [Tribolium castaneum]	264.0	[0..3]	[378..2474]

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Predicted Domain #1

Region A:
Residues: [1-445]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDADAHKV GLIPVTLMVS GNIMGSGVFL LPANLASTGG IAIYGWLVTI IGALGLSMVY  60
   61 AKMSFLDPSP GGSYAYARRC FGPFLGYQTN VLYWLACWIG NIAMVVIGVG YLSYFFPILK 120
  121 DPLVLTITCV VVLWIFVLLN IVGPKMITRV QAVATVLALI PIVGIAVFGW FWFRGETYMA 180
  181 AWNVSGLGTF GAIQSTLNVT LWSFIGVESA SVAAGVVKNP KRNVPIATIG GVLIAAVCYV 240
  241 LSTTAIMGMI PNAALRVSAS PFGDAARMAL GDTAGAIVSF CAAAGCLGSL GGWTLLAGQT 300
  301 AKAAADDGLF PPIFARVNKA GTPVAGLIIV GILMTIFQLS SISPNATKEF GLVSSVSVIF 360
  361 TLVPYLYTCA ALLLLGHGHF GKARPAYLAV TTIAFLYCIW AVVGSGAKEV MWSFVTLMVI 420
  421 TAMYALNYNR LHKNPYPLDA PISKD

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.23
Match:	2a65A
Description:	Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
substrate-specific transmembrane transporter activity	2.74779078524788	bayes_pls_golite062009
substrate-specific transporter activity	2.49498661846993	bayes_pls_golite062009
cation transmembrane transporter activity	2.16798643239726	bayes_pls_golite062009
ion transmembrane transporter activity	2.13565576681993	bayes_pls_golite062009
binding	0.55120193133745	bayes_pls_golite062009
transporter activity	0.13055672366183	bayes_pls_golite062009
transmembrane transporter activity	0.0150231301077546	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: