YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Structure Prediction Details

Protein: CE37018
Organism: Caenorhabditis elegans
Length: 600 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



[What does the above image mean?]


[Show Ginzu Version Information]


Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE37018.

Description E-value Query
Range
Subject
Range
gi|109462002, gi... - gi|149055799|gb|EDM07230.1| E2F transcription factor 8 [Rattus norvegicus], gi|109462002|ref|XP_0010...
386.0 [0..1] [592..18]

Back

Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTIFGSSNA MFLNIEANKE NIPPGTEFKK ESFVLPEPRV NRTTDPDHEN LLPSPVPRPS  60
   61 PAMSQLSDAS FLSQDGGAVN TSADE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [86-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ADDDLEVTSR KEKSLGLLCQ RFLIAINEET VGSSTREVHL ETVARKMNVE KRRIYDIVNV  60
   61 MEALDAMQKT 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.522879
Match: 1cf7A
Description: Cell cycle transcription factor E2F-4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.835523092977445 bayes_pls_golite062009
transcription regulator activity 0.4843036104266 bayes_pls_golite062009
nucleic acid binding 0.37117756729668 bayes_pls_golite062009
DNA binding 0.3118855114645 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [156-275]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NKSYYQWQGL ESLPKLMFDL QNEAVEEGLP ERVLRVEQAM CSFTELSSPR GKQGFKDIVG  60
   61 SFVSCTSTPT TPSTSFDSVT VKMEPAGLLE KRSRVDTRDR QGRNSLAQLC RRFLMVLLSN 120
  121 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.154902
Match: 2azeA
Description: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [276-346]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKNIRKVSLD VASTVLIKDP ETEGFEPPSR SRCRRLYDIA NVLVALGLIK KVHYLFGTKK  60
   61 IPLFVYCGPE P

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.36
Match: 1cf7A
Description: Cell cycle transcription factor E2F-4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 0.683379929086364 bayes_pls_golite062009
transcription regulator activity 0.16959343932447 bayes_pls_golite062009
nucleic acid binding 0.0949481158963694 bayes_pls_golite062009
DNA binding 0.00746597740509714 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [347-461]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DQTGSFDVFQ SVERLLSSSQ NVPQTPIIKA QTDKIVQQIA GFGKRTLSEQ NLTKPSGNTP  60
   61 KIAKIKSAAV RSSPMYMENN LFMFAEVVTA EAAAEKMRYD AFAQLSRTIL GSVAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.154902
Match: 2azeB
Description: Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [462-600]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 INSLNAPLTS SQHPMTSRLP PLPMAPLQLP KLPEIPKPQA QKQFTFPATS RPRFNFPDYT  60
   61 PVQSTIRPLV SQMTFPQESS QLHNLDVKPK HLMSNILGES KKFKNNQNTF EHTTSSAFQV 120
  121 VKKGETRPKK VFGEIQNLQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle