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View Structure Prediction Details

Protein: hlh-14
Organism: Caenorhabditis elegans
Length: 246 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for hlh-14.

Description E-value Query
Range
Subject
Range
gi|33355711 - gi|33355711|gb|AAQ16205.1| eukaryotic myogenic factor MYF-6 [Sus scrofa]
124.0 [0..2] [245..1]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMLESLIVIF LNSHSCKIFQ ICTSSQSFDL ELFNSSLYNL VPIRFVPIST LLVPPIRLSR  60
   61 PAFPLTISLI HSVHPHSLLA TTVFPLSFYF PAQQKKEAMA K

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [102-246]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNQVARNERE RKRVHQVNHG FDVLRNRLQP KNHTKKWSKA DTLREAVKYI QQLQVLLNQD  60
   61 PQQPSVSSST PDYTMNNSNN FNNYAVKEEF SMYLPQNYCP QNQMSVPHGD VSHNFNSPTS 120
  121 SVSSSSYSPT QMCYPPVSYS NYPHH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 1r05A
Description: Solution Structure of Max B-HLH-LZ
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.47866819971988 bayes_pls_golite062009
transcription regulator activity 2.04191582741352 bayes_pls_golite062009
DNA binding 1.881116513908 bayes_pls_golite062009
transcription factor activity 1.75305749487981 bayes_pls_golite062009
nucleic acid binding 1.70236865157557 bayes_pls_golite062009
protein binding 0.880820411513 bayes_pls_golite062009
transcription activator activity 0.314165294474 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle