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View Structure Prediction Details

Protein: CNGC6_ARATH
Organism: Arabidopsis thaliana
Length: 747 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CNGC6_ARATH.

Description E-value Query
Range
Subject
Range
CNGC9_ARATH - Putative cyclic nucleotide-gated ion channel 9 OS=Arabidopsis thaliana GN=CNGC9 PE=2 SV=1
407.0 [0..4] [746..3]

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Predicted Domain #1
Region A:
Residues: [1-84]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDTCGPKGV KSQVISGQRE NFVRLDSMDS RYSQSSETGL NKCTLNIQGG PKRFAQGSKA  60
   61 SSGSFKKGFR KGSEGLWSIG RSIG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [85-230]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGVSRAVFPE DLEVSEKKIF DPQDKFLLLC NKLFVASCIL AVSVDPLFLY LPFINDKAKC  60
   61 VGIDRKLAII VTTIRTVIDS FYLFHMALRF RTAYVAPSSR VFGRGELVID PAQIAKRYLQ 120
  121 QYFIIDLLSV LPVPQIIVWR FLYTSR

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.5
Match: 2a0lA
Description: Crystal structure of KvAP-33H1 Fv complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [231-497]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GANVLATKQA LRYIVLVQYI PRFLRMYPLS SELKRTAGVF AETAWAGAAY YLLLYMLASH  60
   61 IVGALWYLLA LERNNDCWSK ACHNNQNCTR NFLFCGNQNM KGYAAWDNIK VSYLQLKCPV 120
  121 NVPEDEEPPF DFGIYLRALS SGIVSSKNFV SKYFFCLWWG LQNLSTLGQG LETSTYPGEV 180
  181 IFSITLAIAG LLLFALLIGN MQTYLQSLTI RLEEMRVKRR DSEQWMHHRM LPPELRERVR 240
  241 RYDQYKWLET RGVDEENLVQ NLPKDLR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 16.221849
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [498-650]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDIKRHLCLA LVRRVPLFEN MDERLLDAIC ERLKPCLFTE KSYLVREGDP VNEMLFIIRG  60
   61 RLESVTTDGG RSGFYNRSLL KEGDFCGDEL LTWALDPKSG SNLPSSTRTV KALTEVEAFA 120
  121 LIADELKFVA SQFRRLHSRQ VQHTFRFYSQ QWR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.221849
Match: 1wgpA
Description: Solution structure of the cNMP-binding domain from Arabidopsis thaliana cyclic nucleotide-regulated ion channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclic nucleotide-gated ion channel activity 9.28636958853471 bayes_pls_golite062009
intracellular cyclic nucleotide activated cation channel activity 9.28636958853471 bayes_pls_golite062009
intracellular cGMP activated cation channel activity 9.19973076787954 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 8.92326348606261 bayes_pls_golite062009
cGMP binding 7.7575871125398 bayes_pls_golite062009
cyclic nucleotide binding 7.37322432929433 bayes_pls_golite062009
GMP binding 5.49455172024846 bayes_pls_golite062009
ligand-gated channel activity 2.24160712920592 bayes_pls_golite062009
ligand-gated ion channel activity 2.24160712920592 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.1641765932136 bayes_pls_golite062009
ion channel activity 1.99113461395381 bayes_pls_golite062009
gated channel activity 1.96880619620616 bayes_pls_golite062009
channel activity 1.95481941885364 bayes_pls_golite062009
passive transmembrane transporter activity 1.95481941885364 bayes_pls_golite062009
substrate-specific channel activity 1.9532743483506 bayes_pls_golite062009
cation channel activity 1.8875306855156 bayes_pls_golite062009
binding 1.03706428234992 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.745476294699195 bayes_pls_golite062009
ion transmembrane transporter activity 0.646885146396875 bayes_pls_golite062009
substrate-specific transporter activity 0.582561336941853 bayes_pls_golite062009
protein binding 0.560659365968498 bayes_pls_golite062009
cation transmembrane transporter activity 0.489669604147601 bayes_pls_golite062009
transporter activity 0.232363663369302 bayes_pls_golite062009
transmembrane transporter activity 0.209203009093296 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [651-747]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TWAACFMQAA WRRYIKRKKL EQLRKEEEEE EAAAASVIAG GSPYSIRATF LASKFAANAL  60
   61 RSVHKNRTAK STLLLSSTKE LVKFQKPPEP DFSAEDH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 29.39794
Match: 1i5zA
Description: Catabolite gene activator protein (CAP), C-terminal domain; Catabolite gene activator protein, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.33495708130358 bayes_pls_golite062009
DNA binding 1.3643232454136 bayes_pls_golite062009
nucleic acid binding 1.27790965988833 bayes_pls_golite062009
transcription regulator activity 0.931016322768698 bayes_pls_golite062009
transcription factor activity 0.880776321779274 bayes_pls_golite062009
protein binding 0.501337284874473 bayes_pls_golite062009
transcription activator activity 0.225529556408477 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle