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View Structure Prediction Details

Protein: CNG20_ARATH
Organism: Arabidopsis thaliana
Length: 764 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CNG20_ARATH.

Description E-value Query
Range
Subject
Range
gi|76609696 - gi|76609696|ref|XP_614343.2| PREDICTED: similar to potassium voltage-gated channel, subfamily H, mem...
398.0 [0..2] [763..126]

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Predicted Domain #1
Region A:
Residues: [1-177]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASHNENDDI PMLPISDPSS RTRARAFTSR SRSVSLSNPT SSIEGFDTST VVLGYTGPLR  60
   61 TQRRPPLVQM SGPLTSTRKH EPLFLPHPSS DSVGVSSQPE RYPSFAALEH KNSSEDEFVL 120
  121 KHANLLRSGQ LGMCNDPYCT TCPSYYNRKA AQIPTSRVSA LFDSTFHNAL YDDAKGW

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [178-319]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARRFASSVNR YLPGIMNPHA KEVQTWTKFF ALSCLLAIFI DPLFFFLIKV QEQNKCIMID  60
   61 WPMTKAFVAV RSVTDVIFTM NILLQFRLAY VARESTVVGA GQLVSHPKKI ALHYLKGKFF 120
  121 LDLFIVMPLP QILILWIIPA HL

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.72
Match: 2a0lA
Description: Crystal structure of KvAP-33H1 Fv complex
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [320-538]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GASGANYAKN LLRAAVLFQY IPKLYRLLPF LAGQTPTGFI FESAWANFVI NLLTFMLAGH  60
   61 VVGSCWYLFG LQRVNQCLRN ACGNFGRECQ DLIDCGNGNS SVLVRATWKD NASANACFQE 120
  121 DGFPYGIYLK AVNLTNHSNL FTRYSYSLFW GFQQISTLAG NQVPSYFLGE VFFTMGIIGL 180
  181 GLLLFALLIG NMQNFLQALG KRNLEMTLRR RDVEQWMSH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 10.154902
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [539-590]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RRLPDGIRRR VREAERFNWA ATRGVNEELL FENMPDDLQR DIRRHLFKFL KK

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.39
Match: 2ptmA
Description: No description for 2ptmA was found.

Predicted Domain #5
Region A:
Residues: [591-764]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VRIFSLMDEP ILDAIRERLK QRTYIGSSTV LHRGGLVEKM VFIVRGEMES IGEDGSVLPL  60
   61 YEGDVCGEEL LTWCLERSSV NPDGTRIRMP SKGLLSSRNV RCVTNVEAFS LSVADLEDVT 120
  121 SLFSRFLRSH RVQGAIRYDS PYWRLRAARQ IQVAWRYRRR RLHRLCTPQS SYSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 12.69897
Match: 1wgpA
Description: Solution structure of the cNMP-binding domain from Arabidopsis thaliana cyclic nucleotide-regulated ion channel
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclic nucleotide-gated ion channel activity 9.28636958853471 bayes_pls_golite062009
intracellular cyclic nucleotide activated cation channel activity 9.28636958853471 bayes_pls_golite062009
intracellular cGMP activated cation channel activity 9.19973076787954 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 8.92326348606261 bayes_pls_golite062009
cGMP binding 7.7575871125398 bayes_pls_golite062009
cyclic nucleotide binding 7.37322432929433 bayes_pls_golite062009
GMP binding 5.49455172024846 bayes_pls_golite062009
ligand-gated channel activity 2.24160712920592 bayes_pls_golite062009
ligand-gated ion channel activity 2.24160712920592 bayes_pls_golite062009
metal ion transmembrane transporter activity 2.1641765932136 bayes_pls_golite062009
ion channel activity 1.99113461395381 bayes_pls_golite062009
gated channel activity 1.96880619620616 bayes_pls_golite062009
channel activity 1.95481941885364 bayes_pls_golite062009
passive transmembrane transporter activity 1.95481941885364 bayes_pls_golite062009
substrate-specific channel activity 1.9532743483506 bayes_pls_golite062009
cation channel activity 1.8875306855156 bayes_pls_golite062009
binding 1.03706428234992 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.745476294699195 bayes_pls_golite062009
ion transmembrane transporter activity 0.646885146396875 bayes_pls_golite062009
substrate-specific transporter activity 0.582561336941853 bayes_pls_golite062009
protein binding 0.560659365968498 bayes_pls_golite062009
cation transmembrane transporter activity 0.489669604147601 bayes_pls_golite062009
transporter activity 0.232363663369302 bayes_pls_golite062009
transmembrane transporter activity 0.209203009093296 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle