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View Structure Prediction Details

Protein: cash-1
Organism: Caenorhabditis elegans
Length: 678 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for cash-1.

Description E-value Query
Range
Subject
Range
gi|186464325, gi... - gi|23128981|ref|ZP_00110817.1| COG2319: FOG: WD40 repeat [Nostoc punctiforme PCC 73102], gi|18668187...
479.0 [0..34] [677..1032]

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Predicted Domain #1
Region A:
Residues: [1-159]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDASQLSNS QNDKAKDETT RPQYTMSGIL HFIQHEWTKN ELDRTRWEAE RAEMQARIAF  60
   61 LQGERKGQEN LKQDLVRRIK MLEFCLKQER AKNYRLTHNG EEPPSLEESP NENSAPSENS 120
  121 HLTADLDAYI NDAGEAGGSF RQGRLLLKRY LEEIGYSEH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.522879
Match: 2i1jA
Description: No description for 2i1jA was found.

Predicted Domain #2
Region A:
Residues: [160-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IMDVRSFRVK NLLGLLPQAD LPSSERLNGR KEKSDSDSDD GHDDAALDAD ASKAFEEFDF  60
   61 LNNMDAKEKG SDDDWAGKGA SFEKLIKQYK DDPKVKRRSR TSTEESEEKT SNDVQKNLET 120
  121 DVPPGIRSAI DAAAQEELPV R

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [301-678]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RQGRRSANFG YGNGNELDVA LGMQDNDNMD IKDEFKDEDD DPNAQQVKWN IKVTLRSHLD  60
   61 SIRAMQFHPV EPVLFTASED GLIKLWNLDQ KKDEKHNSGG TELEPVYTFR GHKGPVLCLV 120
  121 LSPTGDHLYT GGIDGNICCF NVPSSNGDPF DSYDPRVLTE TLTGHTDAIW SVAYHSSNSR 180
  181 LVSASSDSTV RLWEPGNGEP LIRTIGAPKS GILPTSVDFV STETSHLLAA YTNCYAQIID 240
  241 IDTGSTVMVF DFGAVTGSPT MNKIVSHPTM PLTLIGGEDR TIRYFDNTNG SIIHEAIAHV 300
  301 EGVSSLAIDP NGLYLLSGSH DGSIRMWNME KRSCLQEISA HRKKNDSAVT SVAFHPSRSL 360
  361 IGSAGADSLA KVYVSGSN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 72.69897
Match: 1vyhC
Description: PAF-AH Holoenzyme: Lis1/Alfa2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
6.67009948605948 bayes_pls_golite062009
histone methyltransferase activity (H3-K4 specific) 4.71992275913384 bayes_pls_golite062009
GTPase activity 4.02994814377904 bayes_pls_golite062009
RNA binding 3.77273677738815 bayes_pls_golite062009
actin binding 3.31804728298431 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 3.25521258308263 bayes_pls_golite062009
cytoskeletal protein binding 3.1056443224755 bayes_pls_golite062009
tubulin binding 2.76945430061825 bayes_pls_golite062009
microtubule binding 2.72684103222924 bayes_pls_golite062009
dynein binding 2.54821997913979 bayes_pls_golite062009
binding 2.42570478946173 bayes_pls_golite062009
transcription regulator activity 2.3610959773142 bayes_pls_golite062009
nucleic acid binding 2.30918780727915 bayes_pls_golite062009
snoRNA binding 2.27164613239345 bayes_pls_golite062009
transcription repressor activity 2.14857757853663 bayes_pls_golite062009
dynactin binding 1.92897254169098 bayes_pls_golite062009
histone methyltransferase activity 1.85632145559025 bayes_pls_golite062009
DNA binding 1.71685536470455 bayes_pls_golite062009
actin filament binding 1.5197243426595 bayes_pls_golite062009
structural molecule activity 1.47097979074281 bayes_pls_golite062009
protein methyltransferase activity 1.35170368882651 bayes_pls_golite062009
transcription corepressor activity 1.32093016237625 bayes_pls_golite062009
protein binding 1.21879977456466 bayes_pls_golite062009
transporter activity 1.21549336905926 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 1.21305848427711 bayes_pls_golite062009
lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
protein-lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
histone-lysine N-methyltransferase activity 1.15313682561559 bayes_pls_golite062009
receptor activity 1.12819778129653 bayes_pls_golite062009
G-protein-coupled receptor binding 1.11754260203517 bayes_pls_golite062009
transcription factor activity 1.08768505897883 bayes_pls_golite062009
mRNA binding 1.05053985350578 bayes_pls_golite062009
microtubule plus-end binding 1.01166033978052 bayes_pls_golite062009
molecular transducer activity 0.974380908248463 bayes_pls_golite062009
signal transducer activity 0.974380908248463 bayes_pls_golite062009
angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
type 1 angiotensin receptor binding 0.920323565472959 bayes_pls_golite062009
substrate-specific transporter activity 0.734793983890004 bayes_pls_golite062009
histone binding 0.685319917508843 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.676924760416604 bayes_pls_golite062009
transcription factor binding 0.489473003915035 bayes_pls_golite062009
dynein intermediate chain binding 0.443846546939402 bayes_pls_golite062009
receptor binding 0.316169754698691 bayes_pls_golite062009
transcription cofactor activity 0.30761651528651 bayes_pls_golite062009
protein kinase activity 0.229242350006544 bayes_pls_golite062009
enzyme regulator activity 0.161639372576406 bayes_pls_golite062009
chromatin binding 0.151977098745772 bayes_pls_golite062009
structural constituent of cytoskeleton 0.118975415284669 bayes_pls_golite062009
nucleoside-triphosphatase activity 0.00585398682921312 bayes_pls_golite062009
N-methyltransferase activity 0.00335766408304172 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle