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View Structure Prediction Details

Protein: zag-1
Organism: Caenorhabditis elegans
Length: 596 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for zag-1.

Description E-value Query
Range
Subject
Range
gi|76651068 - gi|76651068|ref|XP_887912.1| PREDICTED: similar to zinc finger protein 192 isoform 5 [Bos taurus]
786.0 [0..3] [594..326]

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Predicted Domain #1
Region A:
Residues: [1-128]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDIAEAMPT TASSLPSDEA LRKFKCPECT KAFKFKHHLK EHIRIHSGEK PFECQQCHKR  60
   61 FSHSGSYSSH MSSKKCVQQA SPSMVTPFNP YQLMMYRNIM LQLQTPQVSF LPSTAANNMD 120
  121 YMSLLQAN

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.045757
Match: 2dlkA
Description: No description for 2dlkA was found.

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.14649486810497 bayes_pls_golite062009
DNA binding 2.89992872665011 bayes_pls_golite062009
nucleic acid binding 2.66588130528088 bayes_pls_golite062009
transcription factor activity 1.97913234583912 bayes_pls_golite062009
binding 1.7678140110688 bayes_pls_golite062009
transcription repressor activity 1.56441586442357 bayes_pls_golite062009
protein binding 1.33682539095771 bayes_pls_golite062009
catalytic activity 0.616333600617445 bayes_pls_golite062009
transcription activator activity 0.35578487491271 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.29294316958168 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [129-196]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LFQSLENGTS PTPTQEPSAP ASPEPKIEVV DEPEVSSEVK TEVKTEVKTE DSVPEESITP  60
   61 AVSMSLSP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [197-349]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 APEQNGNESM NNGGSGSDGK SSPDWRPLRS RSFLNDSQVA VLQNHFKRNP FPSKYELSAV  60
   61 AEQIGVNKRV VQVWFQNTRA KERRSNRLPS MPRGSVASAA AAAATSPTVW QTPVQLMAAW 120
  121 ASQFSNGNNS LTASQDERNN ENTDEVMDHD GLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.69897
Match: 1tf6A
Description: Transcription factor IIIA, TFIIIA
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 3.14649486810497 bayes_pls_golite062009
DNA binding 2.89992872665011 bayes_pls_golite062009
nucleic acid binding 2.66588130528088 bayes_pls_golite062009
transcription factor activity 1.97913234583912 bayes_pls_golite062009
binding 1.7678140110688 bayes_pls_golite062009
transcription repressor activity 1.56441586442357 bayes_pls_golite062009
protein binding 1.33682539095771 bayes_pls_golite062009
catalytic activity 0.616333600617445 bayes_pls_golite062009
transcription activator activity 0.35578487491271 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.29294316958168 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [350-430]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGKETPLDLT LSTDDTEPEW SPEKLIGFLD QTGGVIQELL RQAGNGFVTN QEDEEEKPIK  60
   61 AEESPVSSGS SSIWPSFIGQ Y

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 0.983
Match: 1neqA
Description: SOLUTION STRUCTURE OF THE MU NER PROTEIN BY MULTIDIMENSIONAL NMR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
DNA binding 3.50333148278009 bayes_pls_golite062009
transcription regulator activity 3.22435490927648 bayes_pls_golite062009
nucleic acid binding 3.13941403740118 bayes_pls_golite062009
binding 2.1596228032617 bayes_pls_golite062009
transcription factor activity 2.10376028888832 bayes_pls_golite062009
transcription repressor activity 1.47303242361831 bayes_pls_golite062009
protein binding 0.835527357717776 bayes_pls_golite062009
catalytic activity 0.416161499675821 bayes_pls_golite062009
RNA polymerase II transcription factor activity 0.0407275201491086 bayes_pls_golite062009

Predicted Domain #5
Region A:
Residues: [431-596]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSILDSASLS VLEKALDQQK SSEDDASSLC SNESKLLKFP TTPLKEEEGL FSCDQCDKVF  60
   61 GKQSSLARHK YEHSGQRPYK CDICEKAFKH KHHLTEHKRL HSGEKPFQCD KCLKRFSHSG 120
  121 SYSQHMNHRY SYCKPYREQP ASPSDVLNGG SVTVSPSSSN TPPPST

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 57.154902
Match: 2i13A
Description: No description for 2i13A was found.

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Created and Maintained by: Michael Riffle