| Protein: | nhr-1 |
| Organism: | Caenorhabditis elegans |
| Length: | 445 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-1.
| Description | E-value | Query Range |
Subject Range |
|
|
318.0 | [0..4] | [444..383] |
|
Region A: Residues: [1-155] |
1 11 21 31 41 51
| | | | | |
1 MNGTLADQLQ SHLANYGQPM VNSQRNEDPS MYMNGSAASV SHTNGSSSMG NDQKFPSYKR 60
61 MAQRRKVPEG ELCAVCSDLA TGYHYGVASC NGCKTFFRRT IVSEQTFICQ YNGNCDVNKN 120
121 IRCACRHCRF NKCLLVGMDA KALQIPAIQN DRDRI
|
| Detection Method: |  |
| Confidence: | 25.522879 |
| Match: | 2a66A |
| Description: | Human Liver Receptor Homologue DNA-Binding Domain (hLRH-1 DBD) in Complex with dsDNA from the hCYP7A1 Promoter |
Matching Structure (courtesy of the PDB): |
|
|
Region A: Residues: [156-445] |
1 11 21 31 41 51
| | | | | |
1 GPTKKIKMSS GSDDEQATTP HRLQDQEIID QLTQVEGLCQ ELRRCIIPEV TGVTHALTSP 60
61 CLLFETTDLK VDVSLTNTIF KELFPASMND IRMWNIREMR ICIEWAKTFD VYQRLNLFDQ 120
121 FALVRNFAFA FNLLNRVFYS PDHGPDKIVF QNGAFIMRQP QQQVQLSGCR PIYTRQMDEI 180
181 MIPFRKLQLS VAEFATFKAA LFFNPDALDL SPQAKQEVFE ERNKYLGGLF TCITQKIGIP 240
241 TGVQKYGSLL MMTASIQNIL AQNEENMQVM ELFKNWEVDP FVKELCMKRA
|
| Detection Method: | |
| Confidence: | 42.154902 |
| Match: | 1xdkB |
| Description: | Crystal Structure of the RARbeta/RXRalpha Ligand Binding Domain Heterodimer in Complex with 9-cis Retinoic Acid and a Fragment of the TRAP220 Coactivator |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| transcription regulator activity | 5.53061626347066 | bayes_pls_golite062009 |
| DNA binding | 4.92165988569962 | bayes_pls_golite062009 |
| steroid hormone receptor activity | 4.81441024181511 | bayes_pls_golite062009 |
| nucleic acid binding | 4.78024150262074 | bayes_pls_golite062009 |
| transcription activator activity | 4.53302455129434 | bayes_pls_golite062009 |
| sequence-specific DNA binding | 4.11614358606713 | bayes_pls_golite062009 |
| transcription factor activity | 4.0914094580319 | bayes_pls_golite062009 |
| nuclear hormone receptor binding | 3.91470119037087 | bayes_pls_golite062009 |
| ligand-dependent nuclear receptor activity | 3.89763470197726 | bayes_pls_golite062009 |
| binding | 3.85318710398432 | bayes_pls_golite062009 |
| transcription repressor activity | 3.83878598697109 | bayes_pls_golite062009 |
| hormone receptor binding | 3.79647267365529 | bayes_pls_golite062009 |
| molecular transducer activity | 3.57626193382263 | bayes_pls_golite062009 |
| signal transducer activity | 3.57626193382263 | bayes_pls_golite062009 |
| receptor activity | 3.45094937361521 | bayes_pls_golite062009 |
| protein binding | 3.21524787168952 | bayes_pls_golite062009 |
| transcription activator binding | 2.98235973123409 | bayes_pls_golite062009 |
| estrogen receptor activity | 2.84886725099086 | bayes_pls_golite062009 |
| transcription factor binding | 2.68044489404568 | bayes_pls_golite062009 |
| ecdysteroid hormone receptor activity | 2.54335605534182 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity | 2.38308182853979 | bayes_pls_golite062009 |
| transcription coactivator activity | 2.27959329058894 | bayes_pls_golite062009 |
| hormone binding | 2.22128813425565 | bayes_pls_golite062009 |
| transcription cofactor activity | 1.73827483890179 | bayes_pls_golite062009 |
| structure-specific DNA binding | 1.70383793233433 | bayes_pls_golite062009 |
| retinoic acid receptor binding | 1.59968001933699 | bayes_pls_golite062009 |
| retinoid binding | 1.57244905045132 | bayes_pls_golite062009 |
| estrogen response element binding | 1.56094639526803 | bayes_pls_golite062009 |
| double-stranded DNA binding | 1.48246587604476 | bayes_pls_golite062009 |
| isoprenoid binding | 1.45798199211445 | bayes_pls_golite062009 |
| retinoid X receptor binding | 1.45560845709347 | bayes_pls_golite062009 |
| specific RNA polymerase II transcription factor activity | 1.34794228300778 | bayes_pls_golite062009 |
| promoter binding | 1.28787959668198 | bayes_pls_golite062009 |
| palmitoyl-CoA hydrolase activity | 1.23181585568439 | bayes_pls_golite062009 |
| transcription corepressor activity | 0.995333369475571 | bayes_pls_golite062009 |
| steroid binding | 0.933060984463406 | bayes_pls_golite062009 |
| retinoic acid receptor activity | 0.853869057774515 | bayes_pls_golite062009 |
| protein dimerization activity | 0.797229273848179 | bayes_pls_golite062009 |
| steroid hormone receptor binding | 0.754240851368212 | bayes_pls_golite062009 |
| retinoic acid binding | 0.676688935879073 | bayes_pls_golite062009 |
| protein N-terminus binding | 0.57701453824007 | bayes_pls_golite062009 |
| thyroid hormone receptor activity | 0.49784404390361 | bayes_pls_golite062009 |
| lipid binding | 0.475303782949439 | bayes_pls_golite062009 |
| protein heterodimerization activity | 0.45265806678057 | bayes_pls_golite062009 |
| vitamin D3 receptor activity | 0.428420599209378 | bayes_pls_golite062009 |
| receptor binding | 0.418843034756825 | bayes_pls_golite062009 |
| androgen receptor activity | 0.399730816072004 | bayes_pls_golite062009 |
| ligand-regulated transcription factor activity | 0.202197503742221 | bayes_pls_golite062009 |
| RNA polymerase II transcription factor activity, enhancer binding | 0.15737167800277 | bayes_pls_golite062009 |
| catalytic activity | 0.106902059021677 | bayes_pls_golite062009 |
| androgen binding | 0.0219623894804069 | bayes_pls_golite062009 |
