| Protein: | grk-2 |
| Organism: | Caenorhabditis elegans |
| Length: | 707 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for grk-2.
| Description | E-value | Query Range |
Subject Range |
|
|
557.0 | [0..1] | [684..1] |
|
Region A: Residues: [1-707] |
1 11 21 31 41 51
| | | | | |
1 MADLEAVLAD VSYLMAMEKS RSQPAARASK RIVLPDPSVR SIMQKFLEKS GDMKFDKIFN 60
61 QKLGFLLLKD YAENVSESPC PQIKFYEAIK EYEKMETPDE RLTKAREIYD HHIMVEMLAH 120
121 AHNYSKESLQ HVQYHLLKQN VPPDLFHRYV LEICDQLRGD IFQRFLESDK FTRFCQWKNL 180
181 ELNMQLTMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER 240
241 IMLSLVSTGQ DCPFIVCMTY AFQSPDKLCF ILDLMNGGDL HYHLSQHGVF TEQEMIFYAS 300
301 EVILGLEHMH NRFVVYRDLK PANILLDENG HVRVSDLGLA CDYSKKKPHA SVGTHGYMAP 360
361 EVLAKGVAYD SSADWFSLGC MLYKLLKGHS PFRQHKSKDK NEIDKMTLTQ DIELPNEGLS 420
421 KDCRDLLEGL LKRDVPDRLG CRGKGPTEVK EHPFFKDVDW QTVYLRRMTP PLIPPRGEVN 480
481 AADAFDIGNF DDDEVKGVKL QDGDSDLYKN FNIVISERWQ NEIAETIFEV VNQDADKAES 540
541 KKRSKQKIKV AVEEKDSDVI VHGYIKKLGG PFTSAWQTKY GKLYPSRLEL YPESLTAKPE 600
601 LVFMDQIEDV CAEMQTIKGE TAIIVKLRDG FKEPKICLTN SDEISLKEWH TSLRTAHKVS 660
661 QELLQRMGRK AIKIYGVNHD PMLSESERPG SVTRAFLNRA SSVDSGV
|
| Detection Method: |  |
| Confidence: | 153.0 |
| Match: | 1omwA |
| Description: | G-protein coupled receptor kinase 2, N-terminal domain; G-protein coupled receptor kinase 2 (beta-adrenergic receptor kinase 1); G-protein coupled receptor kinase 2 |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| cyclic nucleotide-dependent protein kinase activity | 4.97855712164511 | bayes_pls_golite062009 |
| insulin-like growth factor receptor binding | 4.68588428747284 | bayes_pls_golite062009 |
| cAMP-dependent protein kinase activity | 4.66277812893755 | bayes_pls_golite062009 |
| structural molecule activity | 4.25992091947152 | bayes_pls_golite062009 |
| SH2 domain binding | 4.2225235101534 | bayes_pls_golite062009 |
| actin binding | 3.72754591832642 | bayes_pls_golite062009 |
| phosphoinositide 3-kinase binding | 3.48970773098023 | bayes_pls_golite062009 |
| cytoskeletal protein binding | 3.48744511411671 | bayes_pls_golite062009 |
| binding | 3.29080729281876 | bayes_pls_golite062009 |
| insulin receptor activity | 3.256741381527 | bayes_pls_golite062009 |
| protein binding | 3.17213698546013 | bayes_pls_golite062009 |
| PTB domain binding | 3.02789234463297 | bayes_pls_golite062009 |
| insulin receptor binding | 2.87341016128079 | bayes_pls_golite062009 |
| tau-protein kinase activity | 2.37138140221719 | bayes_pls_golite062009 |
| tubulin binding | 2.18641675163967 | bayes_pls_golite062009 |
| transcription regulator activity | 2.10584700564436 | bayes_pls_golite062009 |
| actin filament binding | 2.03444575838575 | bayes_pls_golite062009 |
| microtubule binding | 1.88110801192607 | bayes_pls_golite062009 |
| general RNA polymerase II transcription factor activity | 1.8384977631304 | bayes_pls_golite062009 |
| acetylcholine receptor activator activity | 1.83545227594542 | bayes_pls_golite062009 |
| receptor signaling protein serine/threonine kinase activity | 1.81249386965144 | bayes_pls_golite062009 |
| DNA binding | 1.77960272183811 | bayes_pls_golite062009 |
| armadillo repeat domain binding | 1.70850996351356 | bayes_pls_golite062009 |
| insulin receptor substrate binding | 1.62657794525303 | bayes_pls_golite062009 |
| molecular transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| signal transducer activity | 1.55319485371003 | bayes_pls_golite062009 |
| nucleic acid binding | 1.55295906221034 | bayes_pls_golite062009 |
| phosphotransferase activity, alcohol group as acceptor | 1.53043443218632 | bayes_pls_golite062009 |
| kinase activity | 1.49733072352288 | bayes_pls_golite062009 |
| transferase activity, transferring phosphorus-containing groups | 1.36365892826676 | bayes_pls_golite062009 |
| ErbB-3 class receptor binding | 1.34841233233438 | bayes_pls_golite062009 |
| protein kinase activity | 1.34246406302496 | bayes_pls_golite062009 |
| ErbB-2 class receptor binding | 1.33825339298024 | bayes_pls_golite062009 |
| transporter activity | 1.28986800087234 | bayes_pls_golite062009 |
| gamma-tubulin binding | 1.28511591054866 | bayes_pls_golite062009 |
| brain-derived neurotrophic factor binding | 1.28495809513039 | bayes_pls_golite062009 |
| insulin binding | 1.23861703046323 | bayes_pls_golite062009 |
| receptor activity | 1.1755016270537 | bayes_pls_golite062009 |
| enzyme binding | 1.17212675145623 | bayes_pls_golite062009 |
| transmembrane receptor activity | 1.1152029796159 | bayes_pls_golite062009 |
| transcription factor activity | 1.10928254946881 | bayes_pls_golite062009 |
| phospholipid binding | 1.09683218092034 | bayes_pls_golite062009 |
| Ran GTPase binding | 1.07023555877478 | bayes_pls_golite062009 |
| transferase activity | 1.05502123133116 | bayes_pls_golite062009 |
| receptor binding | 1.00859318603128 | bayes_pls_golite062009 |
| receptor signaling protein activity | 1.00400540041137 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.97575992765505 | bayes_pls_golite062009 |
| oxidoreductase activity | 0.965872107791437 | bayes_pls_golite062009 |
| kinase binding | 0.961706066143 | bayes_pls_golite062009 |
| cyclin-dependent protein kinase activity | 0.959360414036299 | bayes_pls_golite062009 |
| protein domain specific binding | 0.90578029954417 | bayes_pls_golite062009 |
| JUN kinase kinase kinase kinase activity | 0.886904175966993 | bayes_pls_golite062009 |
| growth factor binding | 0.86076618871384 | bayes_pls_golite062009 |
| insulin-like growth factor II binding | 0.856861384729301 | bayes_pls_golite062009 |
| MAP kinase activity | 0.81943579965027 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 0.79883446648737 | bayes_pls_golite062009 |
| phosphoinositide binding | 0.71817045430443 | bayes_pls_golite062009 |
| structural constituent of muscle | 0.70794260327482 | bayes_pls_golite062009 |
| protein kinase binding | 0.67284191028382 | bayes_pls_golite062009 |
| profilin binding | 0.66906205737225 | bayes_pls_golite062009 |
| protein serine/threonine kinase activity | 0.611829373978789 | bayes_pls_golite062009 |
| Janus kinase activity | 0.580310109637219 | bayes_pls_golite062009 |
| I-SMAD binding | 0.568054578050901 | bayes_pls_golite062009 |
| protein complex binding | 0.55916857709427 | bayes_pls_golite062009 |
| protein serine/threonine/tyrosine kinase activity | 0.48345772948903 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.450699332958421 | bayes_pls_golite062009 |
| protein kinase C activity | 0.41587987561486 | bayes_pls_golite062009 |
| magnesium ion binding | 0.393328812780268 | bayes_pls_golite062009 |
| 3-phosphoinositide-dependent protein kinase binding | 0.372842462336059 | bayes_pls_golite062009 |
| MAP kinase kinase kinase activity | 0.37115026509016 | bayes_pls_golite062009 |
| mRNA binding | 0.369721687873392 | bayes_pls_golite062009 |
| GTPase regulator activity | 0.355387992614734 | bayes_pls_golite062009 |
| structural constituent of cytoskeleton | 0.35466574267734 | bayes_pls_golite062009 |
| MAP kinase kinase activity | 0.35402045013148 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 0.335498703113274 | bayes_pls_golite062009 |
| RNA binding | 0.324381862881119 | bayes_pls_golite062009 |
| transmembrane receptor protein tyrosine kinase signaling protein activity | 0.28468123649303 | bayes_pls_golite062009 |
| transmembrane receptor protein serine/threonine kinase activity | 0.20643152368029 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity | 0.20643152368029 | bayes_pls_golite062009 |
| enzyme regulator activity | 0.189879136353541 | bayes_pls_golite062009 |
| photoreceptor activity | 0.187612589250841 | bayes_pls_golite062009 |
| ion transmembrane transporter activity | 0.148194101970458 | bayes_pls_golite062009 |
| G-protein-coupled receptor binding | 0.12466518799375 | bayes_pls_golite062009 |
| peptide binding | 0.118578378753757 | bayes_pls_golite062009 |
| alpha-catenin binding | 0.102004310679969 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.0611639610381174 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.0524559849408587 | bayes_pls_golite062009 |
| transforming growth factor beta receptor activity, type I | 0.0506751594607393 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.0498422520006935 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.0040394359628233 | bayes_pls_golite062009 |
