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View Structure Prediction Details

Protein: lgc-33
Organism: Caenorhabditis elegans
Length: 444 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lgc-33.

Description E-value Query
Range
Subject
Range
gi|73992736 - gi|73992736|ref|XP_543097.2| PREDICTED: similar to Neuronal acetylcholine receptor protein, alpha-4 ...
278.0 [0..20] [416..86]

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Predicted Domain #1
Region A:
Residues: [1-308]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVASKKIGMM AFTKLACLLL LFYQFSLVSS ISQNELNELS RKFKYYHSAV RPAAPDNFVS  60
   61 DRNGTFFNIP VEIHLLATRI VNRNLYLEVI IVMTWIDERL RLRELQDRFS MPSEYPPWHP 120
  121 SLVFAPPVTS KYTTLAPTSG TVNSYNTIKT TVECQTNAWK YPFESFTCTL SVGPEGDETL 180
  181 TVAQFHDLRS HTQKLLTNVF LGDYPTCSLE FIFKSEWPRA LLSSFLPSIL IVSSVFFAQW 240
  241 KRRKIQILVS LAAMLCSQRP YTSTTLMDLW LCANFIHSVF LVFVDLTLPA RRVRYTLMVH 300
  301 VDEEKKQA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 48.522879
Match: 2bg9A
Description: Refined structure of the nicotinic acetylcholine receptor at 4A resolution.
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [309-444]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NPVKIMTSGR FFGCSSASFE FIKKLSTNKL CTIKFHTISG NLHSVSLRLS SSHTIYLADT  60
   61 EHSGPLRYVN HVIDYLMKKE HKPRTTIVTA CPGPTPIQRQ ITTAMLGNRK RAALFCIFLS 120
  121 YLTFLLIYAI IVIVID

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.39794
Match: 1oedB
Description: Acetylcholine receptor protein, beta chain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transporter activity 0.8634160537398 bayes_pls_golite062009
transmembrane transporter activity 0.85769987951557 bayes_pls_golite062009
channel activity 0.82494017759356 bayes_pls_golite062009
passive transmembrane transporter activity 0.82494017759356 bayes_pls_golite062009
substrate-specific transporter activity 0.699135829541381 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.69403270260693 bayes_pls_golite062009
ion transmembrane transporter activity 0.68865958955334 bayes_pls_golite062009
substrate-specific channel activity 0.67623695447613 bayes_pls_golite062009
ion channel activity 0.675765443996379 bayes_pls_golite062009
gated channel activity 0.60374435462213 bayes_pls_golite062009
ligand-gated ion channel activity 0.60262355448371 bayes_pls_golite062009
ligand-gated channel activity 0.60262355448371 bayes_pls_golite062009
cation transmembrane transporter activity 0.544647628998121 bayes_pls_golite062009
metal ion transmembrane transporter activity 0.537135922480839 bayes_pls_golite062009
cation channel activity 0.53391585932077 bayes_pls_golite062009
excitatory extracellular ligand-gated ion channel activity 0.463355765957441 bayes_pls_golite062009
extracellular ligand-gated ion channel activity 0.463355765957441 bayes_pls_golite062009
nicotinic acetylcholine-activated cation-selective channel activity 0.26375810963714 bayes_pls_golite062009
binding 0.227765742225932 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle