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View Structure Prediction Details

Protein: kap-1
Organism: Caenorhabditis elegans
Length: 696 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for kap-1.

Description E-value Query
Range
Subject
Range
gi|9800185 - gi|9800185|gb|AAF99086.1|AF149287_1 KAP [Caenorhabditis elegans]
374.0 [0..1] [696..1]

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Predicted Domain #1
Region A:
Residues: [1-100]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNQVSIDAHP SDQAIIVRFE QSPTNVESLG HQKIIHLKEM SLDVDIRALS NVILQKCLFI  60
   61 PATSRSQLEQ VLFYIQKRGN QRISARSRSS SAVSFDRRPI 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.39794
Match: 2c1tA
Description: Structure of the Kap60p:Nup2 complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [101-696]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HSPTISAELG KIDEYIECFY GETSVEKNKG AVALYELSKN PQNLTQLVNN ETLMMALARV  60
   61 FREDWKKHFE VGTNIMNLFV NISKFSCLHG ILLHHKIGTL CVNAMEHETK RYDFWIAEMK 120
  121 KTDQETLRKL KTAIRKQAML LAACVTFLTN LATDISVELK MVRRNLVALL VKCLQMSSES 180
  181 TSSLTTATIK FLLKLSIFDE NKIVMEQNGT IEKLLKLFPI QDPELRKAVI MLLFNFSFDS 240
  241 KNLPKMVNGG LVPHMASLLD SDTKALNMMY LLSCNDDAKA MLAYTDAIKL LMKDVLSGTG 300
  301 SEVTKAVLLN ICLEKRNAQL VCGQRGQGLD LLMEMSINSR DLMLIKVVRA ISSHEGATQN 360
  361 MFLKWIETLI GIAKNEGADN SESKSSFGLE CMGTVAELKV APWAKIIQSE NLVPWMKTQL 420
  421 QEGIDESEEV TVLRDIKPLQ LQIVIACGTM ARQLDAARLL APLIDTFVQL LQSCQIDDEF 480
  481 VVQLLYVFLQ FLKHKELSAR LMTQDSALGA HMIDLMHDAN AVVREVCDNA LLIMGEHSKE 540
  541 WAKRIAGERF KWHNAQWLEM VERDDSEFVD YDDEDFGADL KFDHYDDGFD MNEPLF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.0
Match: 1t08A
Description: Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein transporter activity 3.05338750264476 bayes_pls_golite062009
protein binding 2.78733902345842 bayes_pls_golite062009
binding 2.6374633159018 bayes_pls_golite062009
transporter activity 1.55621630624352 bayes_pls_golite062009
substrate-specific transporter activity 1.33334123659384 bayes_pls_golite062009
cytoskeletal protein binding 1.23804310697631 bayes_pls_golite062009
protein transmembrane transporter activity 1.15447282085461 bayes_pls_golite062009
enzyme regulator activity 0.698613639309592 bayes_pls_golite062009
nucleic acid binding 0.425403776087115 bayes_pls_golite062009
actin binding 0.360199499297314 bayes_pls_golite062009
transmembrane transporter activity 0.350388174853674 bayes_pls_golite062009
signal sequence binding 0.27824906981293 bayes_pls_golite062009
cell adhesion molecule binding 0.237512539263598 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.141331164449492 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.0332743336452223 bayes_pls_golite062009
RNA binding 0.0287526191298597 bayes_pls_golite062009
GTPase regulator activity 0.0268373969988844 bayes_pls_golite062009
guanyl ribonucleotide binding 0.00234756529236324 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle