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View Structure Prediction Details

Protein: aex-5
Organism: Caenorhabditis elegans
Length: 537 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for aex-5.

Description E-value Query
Range
Subject
Range
PCSK5_MOUSE, PCK... - Proprotein convertase subtilisin/kexin type 5 OS=Mus musculus GN=Pcsk5 PE=1 SV=2, (Q04592) Proprotei...
417.0 [0..1] [536..17]

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Predicted Domain #1
Region A:
Residues: [1-459]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKLIFLLLLF GVSPIVCQDF EDGVFLAKIT SIDEHDARKI GRRFGFEAQW KLQSYTDVYV  60
   61 GRRLRRRKRG IEDEIVAEMM LSQQVQFIEK LQGFRRYKRA PMTNKGYPVH VWNLTPSLYI 120
  121 REAWEDGFNA SRVTVAVVDD GVDIKHVDLK SAFSPRVSFD FVRFGDLPTP KNSKEFEHGT 180
  181 QCAGLVAMEG QQCGLGVGHG ATLGAIKLLG QDFLNDALEG DALAFQKDLI DIYSVSWGPK 240
  241 DDGKSAEKPA KFTEEAIKNG ALHGRNGKGN IFVWASGNGG VNGDNCAYDG YVSNEYTLSF 300
  301 GVIDASGAPA AYGEGCSSVL AAVSGGDAMI QTTGLESTCS SISGSSASAA IASGIISLVL 360
  361 DANPTLSQRD IQHLIARTSN ASAIRDVELY ENSAGLNFHP KVGFGLLNAQ KLVVMAATWE 420
  421 NVAPQVTCEK MNLANGIIDN SDCDVTKVER VIVSGSIIH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.69897
Match: 1r6vA
Description: Crystal structure of fervidolysin from Fervidobacterium pennivorans, a keratinolytic enzyme related to subtilisin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.77677490610016 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.40501322467328 bayes_pls_golite062009
serine hydrolase activity 4.30899317351154 bayes_pls_golite062009
serine-type peptidase activity 4.29545891350519 bayes_pls_golite062009
nerve growth factor binding 3.93556598541015 bayes_pls_golite062009
endopeptidase activity 3.83336601331518 bayes_pls_golite062009
serine-type endopeptidase activity 3.71508033196614 bayes_pls_golite062009
neurotrophin binding 2.36320382357038 bayes_pls_golite062009
hydrolase activity 2.05732080397524 bayes_pls_golite062009
eukaryotic cell surface binding 1.50287724152407 bayes_pls_golite062009
binding 1.08901362883653 bayes_pls_golite062009
receptor binding 0.961603322073186 bayes_pls_golite062009
catalytic activity 0.597535457699629 bayes_pls_golite062009
exopeptidase activity 0.42083764849682 bayes_pls_golite062009
protein binding 0.380935140681308 bayes_pls_golite062009
growth factor binding 0.340551753396889 bayes_pls_golite062009
glycosaminoglycan binding 0.3360733982591 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [460-537]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PHRGQVQIRL ESPRGTISEL LPLRPKDTSR DLLDWNFVSV NFFGENSRGI WKLHVTSEED  60
   61 DVDFRVEMKM FKVVGTMS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.99
Match: 1p8jA
Description: Furin, C-terminal domain; Furin, N-terminal domain
Matching Structure (courtesy of the PDB):

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