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View Structure Prediction Details

Protein: vhp-1
Organism: Caenorhabditis elegans
Length: 657 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for vhp-1.

Description E-value Query
Range
Subject
Range
gi|12697945 - gi|12697945|dbj|BAB21791.1| KIAA1700 protein [Homo sapiens]
369.0 [0..4] [600..30]

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Predicted Domain #1
Region A:
Residues: [1-171]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVLDTVTIS TCGLAALIRE APDTTLVVDC RGFTEYNESH VRHSMNAFFS KLIRRRLFEN  60
   61 KLDDNCLIHQ LMSCSSGCTK MDEKLDLVLY AEEDKPRGNK RRIASCNAPE STAKIMRVLR 120
  121 ERLEDTDKFR SVMVLEGGFK QFAQQYPQLC ESSEGMTRLP QSLSQPCLSQ P

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 32.0
Match: 1hzmA
Description: Erk2 binding domain of Mapk phosphatase mkp-3
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
phosphoprotein phosphatase activity 4.79074052803751 bayes_pls_golite062009
phosphatase activity 4.46276380920308 bayes_pls_golite062009
phosphoric ester hydrolase activity 4.26891308022499 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 3.37977783690618 bayes_pls_golite062009
protein tyrosine phosphatase activity 2.84204105189999 bayes_pls_golite062009
hydrolase activity 2.12055507229256 bayes_pls_golite062009
binding 1.72957395505299 bayes_pls_golite062009
protein binding 1.56606332199727 bayes_pls_golite062009
transferase activity 1.00600613068372 bayes_pls_golite062009
catalytic activity 0.687308230067573 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [172-383]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TGDGITLITP NIYLGSQIDS LDETMLDALD ISVVINLSMT CPKSVCIKED KNFMRIPVND  60
   61 SYQEKLSPYF PMAYEFLEKC RRAGKKCLIH CLAGISRSPT LAISYIMRYM KMGSDDAYRY 120
  121 VKERRPSISP NFNFMGQLLE YENVLIKDHV LDYNQASRPH RHMDYYGPSD LCPPKVPKSA 180
  181 SSNCVFPGST HDESSPSSPS VSEGSAASEP ET

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.39794
Match: 2g6zA
Description: No description for 2g6zA was found.

Predicted Domain #3
Region A:
Residues: [384-521]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSAASSSST ASAPPSMPST SEQGTSSGTV NVNGKRNMTM DLGLPHRPKA LGLPSRIGTS  60
   61 VAELPSPSTE LSRLSFNGPE AIAPSTPILN FTNPCFNSPI IPVASSSREV ILTLPTPAAS 120
  121 SSSSTSSEPS FDFSSFES

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [522-657]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSSSSIVVEN PFFASTEVPA GSSSISTPSG SQSTPASASS SAASRCRMKG FFKVFSKKAP  60
   61 ASTSTPASST PGTSRAARPE CLRSSGIIIS APVLAITEEE DAESPESGFN EPEVGEEDDD 120
  121 SVSICSTSSL EIPCHQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle