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View Structure Prediction Details

Protein: ttb-1
Organism: Caenorhabditis elegans
Length: 306 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ttb-1.

Description E-value Query
Range
Subject
Range
gi|50751350 - gi|50751350|ref|XP_422356.1| PREDICTED: similar to Transcription initiation factor IIB (General tran...
250.0 [0..4] [305..164]

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Predicted Domain #1
Region A:
Residues: [1-70]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAPVQCPIH PDVHLIEDHR AGDLVCPACG LVVGDRLVDV GTEWRSFSNE RSGNDPSRVG  60
   61 APENPLLSGG 

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 3.1
Match: 1rlyA
Description: RDC-derived models of the zinc ribbon domain of human general transcription TFIIB (zinc bound structures)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 5.56373197054355 bayes_pls_golite062009
transcription elongation regulator activity 4.94644536450092 bayes_pls_golite062009
DNA-directed RNA polymerase activity 4.00205139503916 bayes_pls_golite062009
RNA polymerase activity 4.00205139503916 bayes_pls_golite062009
transcription regulator activity 3.26689775782701 bayes_pls_golite062009
nucleic acid binding 2.22680674586367 bayes_pls_golite062009
binding 2.0546846758949 bayes_pls_golite062009
DNA binding 2.01468878668039 bayes_pls_golite062009
positive transcription elongation factor activity 1.49227692053981 bayes_pls_golite062009
RNA polymerase II transcription factor activity 1.48570514124545 bayes_pls_golite062009
nucleotidyltransferase activity 1.10975425818967 bayes_pls_golite062009
protein binding 0.549662583711205 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.536637459961958 bayes_pls_golite062009
DNA primase activity 0.494157804587957 bayes_pls_golite062009
catalytic activity 0.433059249914853 bayes_pls_golite062009
RNA polymerase II transcription elongation factor activity 0.0384907163875292 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [71-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLSTTIAVGF GGSDSDNSLA NAQRKSMNNT DRQMTAAMSL IREMSERIHL PRNIQDSASR  60
   61 IFKDVLESKA LRGKNNEAQA AACLYIACRK DGVPRTFKEI CAVSRVSKKE IGRCFKIIVR 120
  121 SLETNLEQIT SADFMSRFCG NLSLPNSIQA AATRIAKCAV DMDLVAGRTP ISIAAAAIYM 180
  181 ASQASAEKRS AKEIGDVAGA AEITVRQTYK LLYPKALELF PKDFRFVTPI DALPNS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.69897
Match: 1c9bA
Description: Transcription factor IIB (TFIIB), core domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
general RNA polymerase II transcription factor activity 6.34389570239956 bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity 3.19553060844126 bayes_pls_golite062009
protein kinase regulator activity 2.87088741581791 bayes_pls_golite062009
transcription regulator activity 2.795846725429 bayes_pls_golite062009
binding 2.4204867358489 bayes_pls_golite062009
nucleic acid binding 2.04886889839181 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.00665312545368 bayes_pls_golite062009
DNA binding 1.94297811210385 bayes_pls_golite062009
transcription elongation regulator activity 1.69439693414478 bayes_pls_golite062009
kinase regulator activity 1.65109787211976 bayes_pls_golite062009
protein binding 1.47106731485576 bayes_pls_golite062009
transcription factor activity 1.21921365719206 bayes_pls_golite062009
transcription factor binding 0.749278791251235 bayes_pls_golite062009
enzyme regulator activity 0.729629809946521 bayes_pls_golite062009
positive transcription elongation factor activity 0.42590121577004 bayes_pls_golite062009
transcription coactivator activity 0.138191616709499 bayes_pls_golite062009
transcription activator activity 0.0696060248241566 bayes_pls_golite062009

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