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View Structure Prediction Details

Protein: tax-4
Organism: Caenorhabditis elegans
Length: 733 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tax-4.

Description E-value Query
Range
Subject
Range
gi|68359961 - gi|68359961|ref|XP_696520.1| PREDICTED: similar to Cyclic-nucleotide-gated cation channel [Danio rer...
345.0 [0..1] [677..32]

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Predicted Domain #1
Region A:
Residues: [1-430]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTAEPAPDP TNPSTSGLAP TTNGIGSPPP TASAATKFSI LTKFLRRKNQ VHTTTAQQNE  60
   61 FMQKYMPNGN SNAVQPAATG GQPASSDGGS AIEVPPPKES YAVRIRKYLA NYTQDPSTDN 120
  121 FYYWTCVVTV AYIYNLLFVI ARQVFNDLIG PSSQSLCRFY NGTLNSTTQV ECTYNMLTNM 180
  181 KEMPTYSQYP DLGWSKYWHF RMLWVFFDLL MDCVYLIDTF LNYRMGYMDQ GLVVREAEKV 240
  241 TKAYWQSKQY RIDGISLIPL DYILGWPIPY INWRGLPILR LNRLIRYKRV RNCLERTETR 300
  301 SSMPNAFRVV VVVWYIVIII HWNACLYFWI SEWIGLGTDA WVYGHLNKQS LPDDITDTLL 360
  361 RRYVYSFYWS TLILTTIGEV PSPVRNIEYA FVTLDLMCGV LIFATIVGNV GSMISNMSAA 420
  421 RTEFQNKMDG 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.522879
Match: 2a79B
Description: Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [431-496]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKQYMELRKV SKQLEIRVIK WFDYLWTNKQ SLSDQQVLKV LPDKLQAEIA MQVHFETLRK  60
   61 VRIFQD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.154902
Match: 2q0aA
Description: No description for 2q0aA was found.

Predicted Domain #3
Region A:
Residues: [497-733]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CEAGLLAELV LKLQLQVFSP GDFICKKGDI GREMYIVKRG RLQVVDDDGK KVFVTLQEGS  60
   61 VFGELSILNI AGSKNGNRRT ANVRSVGYTD LFVLSKTDLW NALREYPDAR KLLLAKGREI 120
  121 LKKDNLLDEN APEEQKTVEE IAEHLNNAVK VLQTRMARLI VEHSSTEGKL MKRIEMLEKH 180
  181 LSRYKALARR QKTMHGVSID GGDISTDGVD ERVRPPRLRQ TKTIDLPTGT ESESLLK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.0
Match: 1ne4A
Description: Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
cyclic nucleotide-gated ion channel activity 10.1422916734545 bayes_pls_golite062009
intracellular cyclic nucleotide activated cation channel activity 10.1422916734545 bayes_pls_golite062009
intracellular ligand-gated ion channel activity 9.72053268940283 bayes_pls_golite062009
cation channel activity 9.48749374439976 bayes_pls_golite062009
ion channel activity 9.4846197809463 bayes_pls_golite062009
metal ion transmembrane transporter activity 9.3929063879608 bayes_pls_golite062009
channel activity 9.25176207085973 bayes_pls_golite062009
passive transmembrane transporter activity 9.25176207085973 bayes_pls_golite062009
substrate-specific channel activity 9.2472549851376 bayes_pls_golite062009
intracellular cGMP activated cation channel activity 9.19973076787954 bayes_pls_golite062009
gated channel activity 9.19042473454294 bayes_pls_golite062009
cGMP binding 7.7575871125398 bayes_pls_golite062009
ligand-gated channel activity 7.41584542512987 bayes_pls_golite062009
ligand-gated ion channel activity 7.41584542512987 bayes_pls_golite062009
cyclic nucleotide binding 7.37322432929433 bayes_pls_golite062009
voltage-gated ion channel activity 6.57272328088253 bayes_pls_golite062009
voltage-gated channel activity 6.54930851487319 bayes_pls_golite062009
ion transmembrane transporter activity 5.54400173845933 bayes_pls_golite062009
GMP binding 5.49455172024846 bayes_pls_golite062009
cation transmembrane transporter activity 5.34760703274696 bayes_pls_golite062009
potassium channel activity 5.29889968906368 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 5.1138025954757 bayes_pls_golite062009
voltage-gated cation channel activity 4.96516802098805 bayes_pls_golite062009
voltage-gated potassium channel activity 4.52895684111035 bayes_pls_golite062009
intracellular cAMP activated cation channel activity 3.95109938608832 bayes_pls_golite062009
transporter activity 3.30740141256752 bayes_pls_golite062009
substrate-specific transporter activity 3.24402760485462 bayes_pls_golite062009
transmembrane transporter activity 3.22443361822344 bayes_pls_golite062009
protein binding 1.86347494944834 bayes_pls_golite062009
signal transducer activity 1.7487659479534 bayes_pls_golite062009
molecular transducer activity 1.7487659479534 bayes_pls_golite062009
binding 1.59096092728475 bayes_pls_golite062009
transcription regulator activity 1.52941414851886 bayes_pls_golite062009
enzyme regulator activity 1.40720858109605 bayes_pls_golite062009
nucleic acid binding 1.33862527414723 bayes_pls_golite062009
DNA binding 1.17942022803543 bayes_pls_golite062009
GTPase regulator activity 0.930640481652164 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.910527807644534 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.848189810874263 bayes_pls_golite062009
transcription factor activity 0.720377542376114 bayes_pls_golite062009
transcription activator activity 0.659469524274627 bayes_pls_golite062009

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