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View Structure Prediction Details

Protein: spk-1
Organism: Caenorhabditis elegans
Length: 698 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for spk-1.

Description E-value Query
Range
Subject
Range
spk-1 - serine\/threonine kinase (2 domains) status:Partially_confirmed UniProt:Q03563 protein_id:CAA79540.2
390.0 [0..54] [695..342]

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Predicted Domain #1
Region A:
Residues: [1-104]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGGPEKNSTV PLPNKKRKKK TNKKKPTAPN TPTSPQAGEK NANLKNGTVT TNGSNHVERT  60
   61 EVNANEERLD DLSVSPGRSD SPGGGGGGHS DSFQDPMDPG EQLG

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [105-355]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SDDEEQEDPR DYKRGGYHPV NIGDVFNARY HVIRKLGWGH FSTVWLAWDT QDKRFVAMKI  60
   61 VKSAEHYTEA ALDEIKLLLS VRSADPNDIG CHKVVQLLDE FTVTGINGQH VAMVFEVLGC 120
  121 NLLKLIIRSN YRGLHLEQVR KICRQVLEAL GYMHEKCGII HTDIKPENVL ITMSREEIKI 180
  181 MAQHAVVARK MNMKMSGSAV STAPDHLVKM AQENMTKNKK KKMKKKAKKQ REKLEAELAG 240
  241 LEGLKMDANG L

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.045757
Match: 1wakA
Description: No description for 1wakA was found.

Predicted Domain #3
Region A:
Residues: [356-414]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEAYNNAPEL ENFNASQVED VTMEDTVNEN GNRNKVEIRS PDRFDRTTLT PFSDPESKF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [415-698]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDLASPSAEY LSSPMSQLPP GGILPAPPVG PNIGDPYCDI DVKIADLGNA CWVNHHYTDD  60
   61 IQTRQYRALE VLIGSGYGPP ADIWSTACMA FELATGDYLF EPHQGDNYSR DEDHLAHISE 120
  121 LLGAIPPSIY KKGKHWREFF HKNGHLLHIH QLKPWSLYEV LRQKYEWSHE DAQQFESFLR 180
  181 PMLDFDQEKR STAKIALKHP FLLPFGGRAP KSDCPPELLS KMFPDGLIPE PFDGNEHQEV 240
  241 YRDENDSRSA SERSANSRSA GGSDDDDEEE FNMNRPGPSG LDLQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 54.154902
Match: 1jnkA
Description: THE C-JUN N-TERMINAL KINASE (JNK3S) COMPLEXED WITH MGAMP-PNP
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein kinase activity 5.08693983533348 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 4.80278598786839 bayes_pls_golite062009
kinase activity 4.59756610116144 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 4.25355168820731 bayes_pls_golite062009
protein serine/threonine kinase activity 4.23864440079487 bayes_pls_golite062009
transferase activity 3.26787750561728 bayes_pls_golite062009
ATP binding 1.87003701072722 bayes_pls_golite062009
adenyl ribonucleotide binding 1.82650528610717 bayes_pls_golite062009
adenyl nucleotide binding 1.79644024762454 bayes_pls_golite062009
purine ribonucleotide binding 1.56978145564551 bayes_pls_golite062009
ribonucleotide binding 1.56956819263374 bayes_pls_golite062009
purine nucleotide binding 1.54471996792105 bayes_pls_golite062009
nucleotide binding 1.53595022832543 bayes_pls_golite062009
binding 1.2544309640633 bayes_pls_golite062009
catalytic activity 1.21655087018101 bayes_pls_golite062009
protein tyrosine kinase activity 1.17063753242103 bayes_pls_golite062009
protein binding 1.1071219729093 bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity 1.05410128646972 bayes_pls_golite062009
receptor signaling protein activity 0.98751004123886 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.439470338563384 bayes_pls_golite062009
magnesium ion binding 0.0936583701619971 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle