YRC Public Data Repository - Protein Structure Prediction

Protein:	CE19046
Organism:	Caenorhabditis elegans
Length:	269 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CE19046.

Description	E-value	Query Range	Subject Range
gi\|152976184, gi... - gi\|89203212\|ref\|ZP_01181903.1\| DNA polymerase III, epsilon subunit:DNA polymerase III, alpha subunit...	226.0	[0..3]	[260..322]
DPO3_CALS4 - DNA polymerase III PolC-type OS=Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242... DPO3_THETN - DNA polymerase III polC-type OS=Thermoanaerobacter tengcongensis GN=polC PE=3 SV=1	225.0	[0..3]	[266..293]
gi\|125973511, gi... - gi\|67917180\|ref\|ZP_00510847.1\| DNA polymerase III, epsilon subunit:DNA polymerase III, alpha subunit...	223.0	[0..4]	[267..335]
gi\|228660107, gi... - gi\|229123331\|ref\|ZP_04252535.1\| DNA polymerase III polC-type [Bacillus cereus 95/8201], gi\|228660107... gi\|21401801, gi\|... - gi\|65321145\|ref\|ZP_00394104.1\| COG2176: DNA polymerase III, alpha subunit (gram-positive type) [Baci... gi\|228947537, gi... - gi\|228947537\|ref\|ZP_04109827.1\| DNA polymerase III polC-type [Bacillus thuringiensis serovar monterr... gi\|227813274, gi... - gi\|227813274\|ref\|YP_002813283.1\| DNA polymerase III, alpha subunit, Gram-positive type [Bacillus ant... gi\|165872624, gi... - gi\|165872624\|ref\|ZP_02217255.1\| DNA polymerase III, alpha subunit, Gram-positive type [Bacillus anth... gi\|170687849, gi... - gi\|170687849\|ref\|ZP_02879063.1\| DNA polymerase III, alpha subunit, Gram-positive type [Bacillus anth... gi\|170128318, gi... - gi\|170706900\|ref\|ZP_02897358.1\| DNA polymerase III, alpha subunit, Gram-positive type [Bacillus anth... gi\|49180595, gi\|... - gi\|49186668\|ref\|YP_029920.1\| DNA polymerase III PolC [Bacillus anthracis str. Sterne], gi\|49180595\|g... gi\|52141670, gi\|... - gi\|52141670\|ref\|YP_085159.1\| DNA polymerase III PolC [Bacillus cereus E33L], gi\|51975139\|gb\|AAU16689... gi\|30258465, gi\|... - gi\|30263821\|ref\|NP_846198.1\| DNA polymerase III PolC [Bacillus anthracis str. Ames], gi\|30258465\|gb\|... gi\|47504393, gi\|... - gi\|47529245\|ref\|YP_020594.1\| DNA polymerase III PolC [Bacillus anthracis str. 'Ames Ancestor'], gi\|4... gi\|190568456, gi... - gi\|190568456\|ref\|ZP_03021363.1\| DNA polymerase III, alpha subunit, Gram-positive type [Bacillus anth... gi\|196042171, gi... - gi\|196042171\|ref\|ZP_03109454.1\| DNA polymerase III, alpha subunit, Gram-positive type [Bacillus cere... gi\|218904946, gi... - gi\|218904946\|ref\|YP_002452780.1\| DNA polymerase III, alpha subunit, Gram-positive type [Bacillus cer... gi\|254759330 - gi\|254759330\|ref\|ZP_05211355.1\| DNA polymerase III PolC [Bacillus anthracis str. Australia 94] gi\|254756009 - gi\|254756009\|ref\|ZP_05208040.1\| DNA polymerase III PolC [Bacillus anthracis str. Vollum] gi\|254721996 - gi\|254721996\|ref\|ZP_05183785.1\| DNA polymerase III PolC [Bacillus anthracis str. A1055] gi\|254683475 - gi\|254683475\|ref\|ZP_05147335.1\| DNA polymerase III PolC [Bacillus anthracis str. CNEVA-9066] gi\|229601637, gi... - gi\|229601637\|ref\|YP_002868056.1\| DNA polymerase III, alpha subunit, Gram-positive type [Bacillus ant...	219.0	[0..3]	[259..322]
gi\|89098599, gi\|... - gi\|89098599\|ref\|ZP_01171481.1\| DNA polymerase III subunit alpha [Bacillus sp. NRRL B-14911], gi\|8908...	219.0	[0..3]	[266..329]
gi\|114843683, gi... - gi\|167040287\|ref\|YP_001663272.1\| DNA polymerase III PolC [Thermoanaerobacter sp. X514], gi\|166854527...	219.0	[0..4]	[263..300]
DPO3_BACHD - DNA polymerase III polC-type OS=Bacillus halodurans GN=polC PE=3 SV=1 DPO3_BACHD - DNA polymerase III PolC-type OS=Bacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / J...	218.0	[0..3]	[259..323]
gi\|49478392, gi\|... - gi\|49478392\|ref\|YP_037879.1\| DNA polymerase III PolC [Bacillus thuringiensis serovar konkukian str. ...	218.0	[0..3]	[259..322]
DPO3_BACCR - DNA polymerase III PolC-type OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 ... gi\|229146389, gi... - gi\|229146389\|ref\|ZP_04274760.1\| DNA polymerase III polC-type [Bacillus cereus BDRD-ST24], gi\|2286370...	217.0	[0..3]	[259..324]
gi\|42738836, gi\|... - gi\|42782909\|ref\|NP_980156.1\| DNA polymerase III, alpha subunit [Bacillus cereus ATCC 10987], gi\|4273...	217.0	[0..3]	[260..322]

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Predicted Domain #1

Region A:
Residues: [1-100]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASKHAAKTV DPKDLSPAWK VLQMKLNEEK AEKEKAAKAE KEANPEGSDD GFTKVQTKKQ  60
   61 KQKMNRKRRA QEALAAASEV KRVHHDIPVV IEDSERGELT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

		MCM Score	SCOP Match	SCOP Description
View	Download	0.818	a.7.5	Tubulin chaperone cofactor A

Predicted Domain #2

Region A:
Residues: [101-269]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVIAIDCEYV GAGMGGTTDI LARISIVNEL GKIVYDKFVK PTEKVTDFRT AVSGIRPENM  60
   61 IKAIPFDRAQ TEVSKLIDGR IVIGHAVHND FRVLKLNHIR KLTRDTAKCT ILKNMANHHG 120
  121 TPSLKKLAKE VLGIEIQRGE HDSITDARVA LRLYEAVKKQ WEAEIKRYR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	31.0
Match:	1wljA
Description:	human ISG20
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ribonuclease activity	5.30591758406946	bayes_pls_golite062009
exoribonuclease activity	3.71639182685131	bayes_pls_golite062009
exoribonuclease activity, producing 5'-phosphomonoesters	3.59362615133405	bayes_pls_golite062009
3'-5'-exoribonuclease activity	3.1992647486402	bayes_pls_golite062009
exonuclease activity	3.13676176369406	bayes_pls_golite062009
nuclease activity	3.11657409772275	bayes_pls_golite062009
ribonuclease H activity	2.91966688044755	bayes_pls_golite062009
single-stranded DNA specific 3'-5' exodeoxyribonuclease activity	2.75003136922541	bayes_pls_golite062009
endonuclease activity	2.63074055051349	bayes_pls_golite062009
endoribonuclease activity	2.59247838057313	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	2.57498413015114	bayes_pls_golite062009
hydrolase activity	2.41899414621161	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	2.04408785855894	bayes_pls_golite062009
3'-5' exonuclease activity	1.44123900197846	bayes_pls_golite062009
catalytic activity	1.25233849524628	bayes_pls_golite062009
nucleic acid binding	1.23371034593624	bayes_pls_golite062009
protein binding	1.16870279238939	bayes_pls_golite062009
deoxyribonuclease activity	1.1219517187744	bayes_pls_golite062009
transcription regulator activity	1.10433412699603	bayes_pls_golite062009
DNA binding	0.860359347662869	bayes_pls_golite062009
binding	0.762139256580538	bayes_pls_golite062009
DNA polymerase activity	0.717600245625866	bayes_pls_golite062009
endoribonuclease activity, producing 5'-phosphomonoesters	0.708753843279937	bayes_pls_golite062009
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.598360955770972	bayes_pls_golite062009
DNA-directed DNA polymerase activity	0.568273228950698	bayes_pls_golite062009
	0.49473250705373	bayes_pls_golite062009
transcription factor activity	0.332903382446869	bayes_pls_golite062009
exodeoxyribonuclease activity	0.278838342302102	bayes_pls_golite062009
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	0.261428436029202	bayes_pls_golite062009
structure-specific DNA binding	0.0701825322473915	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.00214157813118243	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: