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View Structure Prediction Details

Protein: lec-1
Organism: Caenorhabditis elegans
Length: 279 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for lec-1.

Description E-value Query
Range
Subject
Range
lec-2 - galactoside-binding lectin status:Confirmed UniProt:Q20684 protein_id:CAA91327.2
329.0 [0..1] [278..968]
gi|157751472 - gi|157751472|ref|XP_001679448.1| Hypothetical protein CBG02815 [Caenorhabditis briggsae AF16]
gi|39597215, gi|... - gi|39597215|emb|CAE59442.1| Hypothetical protein CBG02815 [Caenorhabditis briggsae], gi|187037107|em...
318.0 [0..1] [279..1]
gi|3341815 - gi|3341815|gb|AAD11972.1| galectin [Haemonchus contortus]
316.0 [0..1] [278..1]
gi|1935058, gi|5... - gi|5070261|gb|AAD39095.1|AF105337_1 galectin GAL-1 [Teladorsagia circumcincta], gi|1935058|gb|AAC475...
314.0 [0..1] [278..1]
gi|433317 - gi|433317|gb|AAA20541.1| beta-galactoside-binding lectin
307.0 [0..1] [277..1]

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Predicted Domain #1
Region A:
Residues: [1-155]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEEPKSYP VPYRSVLQEK FEPGQTLIVK GSTIDESQRF TINLHSKTAD FSGNDVPLHV  60
   61 SVRFDEGKIV LNSFSNGEWG KEERKSNPIK KGDSFDIRIR AHDDRFQIIV DHKEFKDYEH 120
  121 RLPLSSISHL SIDGDLYLNH VHWGGKYYPV PYESG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.154902
Match: 2dycA
Description: No description for 2dycA was found.

Predicted Domain #2
Region A:
Residues: [156-279]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LANGLPVGKS LLVFGTVEKK AKRFHVNLLR KNGDISFHFN PRFDEKHVIR NSLAANEWGN  60
   61 EEREGKNPFE KGVGFDLVIQ NEEYAFQVFV NGERYISFAH RADPHDIAGL QISGDIELSG 120
  121 IQIQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 38.522879
Match: 1w6mA
Description: X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH GALACTOSE
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sugar binding 3.34064405064299 bayes_pls_golite062009
binding 2.40096962515027 bayes_pls_golite062009
monosaccharide binding 2.09529521879228 bayes_pls_golite062009
carbohydrate binding 1.90829797790335 bayes_pls_golite062009
extracellular matrix structural constituent 1.81440764049964 bayes_pls_golite062009
protein binding 1.80794638640093 bayes_pls_golite062009
extracellular matrix binding 1.41229380365824 bayes_pls_golite062009
glycosaminoglycan binding 1.25720635817943 bayes_pls_golite062009
molecular transducer activity 1.24423621131253 bayes_pls_golite062009
signal transducer activity 1.24423621131253 bayes_pls_golite062009
polysaccharide binding 1.09475063562581 bayes_pls_golite062009
pattern binding 0.969915174528009 bayes_pls_golite062009
receptor binding 0.9012250808046 bayes_pls_golite062009
heparin binding 0.526582971950561 bayes_pls_golite062009
receptor activity 0.376562682962271 bayes_pls_golite062009
transcription regulator activity 0.372701974560119 bayes_pls_golite062009
laminin binding 0.31629065463492 bayes_pls_golite062009
fibronectin binding 0.296652398618881 bayes_pls_golite062009
nucleic acid binding 0.216086300988177 bayes_pls_golite062009
transmembrane receptor activity 0.213382263378401 bayes_pls_golite062009
DNA binding 0.157628282318248 bayes_pls_golite062009
growth factor activity 0.119475011376319 bayes_pls_golite062009
lactose binding 0.0476297330938394 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle