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View Structure Prediction Details

Protein: tra-3
Organism: Caenorhabditis elegans
Length: 648 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tra-3.

Description E-value Query
Range
Subject
Range
gi|8132991, gi|4... - gi|8132991|gb|AAF73443.1|AF263609_1 micromolar calcium-activated neutral protease 1 isoform B; CAPN1...
526.0 [0..1] [648..28]

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Predicted Domain #1
Region A:
Residues: [1-648]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTRSEKTRHF GNQNYEKLRK ICIKKKQPFV DTLFPPTNQS LFLEQRQSSD IVWKRPGELH  60
   61 PDPHLFVEGA SPNDVTQGIL GNCWFVSACS ALTHNFKLLA QVIPDADDQE WSTKHAYAGI 120
  121 FRFRFWRFGK WVEVVIDDLL PTRDGKLLFA RSKTPNEFWS ALLEKAFAKL YGCYENLVGG 180
  181 HLSDALQDVS GGVAETLHVR KFLKDDPNDT ELKLFNDLKT AFDKGALVVA AIAARTKEEI 240
  241 EESLDCGLVK GHAYAVSAVC TIDVTNPNER SFTSFIMGSK RKQNLIRLQN PWGEKEWNGA 300
  301 WSDDSPEWQN VSASQLSTMG VQPANSDSDD GDFWMPWESF VHYFTDISLC QLFNTSVFSF 360
  361 SRSYDEQIVF SEWTTNGKKS GAPDDRAGGC HNFKATFCNN PQYIFDIPSP NCSVMFALIQ 420
  421 NDPSEGLKKR EPFVTIGMHV MKVENNRQYR VHTAMHPIAI SDYASGRSVY LHLQSLPRGR 480
  481 YLLIPTTFAP KEQTLFMLRV YSDEHIHFSP LTKHAPKLGL LKCKSAQSVT RLTIHGVDFN 540
  541 SASTGTHNVY AILKDSRKSF RTKTLSGVKS IQWDEQFLFH KSKNRQQYKI EVWEDRKMAR 600
  601 DHLLAQSVII ALIDNENRDT TLQLTDPRGT VIGTVSVTVS AFDDPMYL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 148.0
Match: 1kfuL
Description: Calpain large subunit, C-terminal domain (domain IV); Calpain large subunit, middle domain (domain III); Calpain large subunit, catalytic domain (domain II)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 3.19059336788201 bayes_pls_golite062009
cysteine-type peptidase activity 3.05412701733177 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 2.93596559605971 bayes_pls_golite062009
endopeptidase activity 2.91734319991078 bayes_pls_golite062009
hydrolase activity 2.43328552376748 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
protein binding 1.92445772322782 bayes_pls_golite062009
binding 1.92046698500094 bayes_pls_golite062009
structural constituent of muscle 1.30577051923353 bayes_pls_golite062009
transporter activity 1.21845572420504 bayes_pls_golite062009
actin binding 1.1967948958876 bayes_pls_golite062009
cytoskeletal protein binding 1.19670958990587 bayes_pls_golite062009
signal transducer activity 1.11706264292297 bayes_pls_golite062009
molecular transducer activity 1.11706264292297 bayes_pls_golite062009
small conjugating protein-specific protease activity 1.07520173658976 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
transmembrane transporter activity 1.00091316610003 bayes_pls_golite062009
calcium ion binding 0.687204894708051 bayes_pls_golite062009
motor activity 0.68020805045422 bayes_pls_golite062009
microfilament motor activity 0.515693296786409 bayes_pls_golite062009
ubiquitin-specific protease activity 0.495368836247989 bayes_pls_golite062009
substrate-specific transporter activity 0.484449686814032 bayes_pls_golite062009
transcription regulator activity 0.354062437867002 bayes_pls_golite062009
nucleic acid binding 0.313326619937245 bayes_pls_golite062009
DNA binding 0.306964954191276 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 0.246369226539662 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
active transmembrane transporter activity 0.193338880082314 bayes_pls_golite062009
tubulin binding 0.11107511867058 bayes_pls_golite062009
protein complex binding 0.0676093357928913 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle