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View Structure Prediction Details

Protein: idh-2
Organism: Caenorhabditis elegans
Length: 435 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for idh-2.

Description E-value Query
Range
Subject
Range
gi|114658862 - gi|114658862|ref|XP_510589.2| PREDICTED: isocitrate dehydrogenase 2 (NADP+), mitochondrial isoform 4...
483.0 [0..2] [435..11]

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Predicted Domain #1
Region A:
Residues: [1-435]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSRLTSRNV LLARNVATAA TQERQKIKVD NPVVDLDGDE MTRIIWKEIK NKLILPYLDL  60
   61 DIKYYDLGLE YRDETNDQVT IDAAHAILEH SVGIKCATIT PDEARIKEFN LKKMWLSPNG 120
  121 TIRNILGGTV FREPILCKNI PRLVPGWTQP ITIGRHAFGD QYKCTDLVIP SGSTLQLLVN 180
  181 KPDGSKDVHN VYDFKKSGGV GLAMYNTDES IKGFAHSCFQ YALMKQWPLY LSTKNTILKK 240
  241 YDGRFKDIFQ DIYEKKYEAD FKNNKIWYEH RLIDDQVAQA LKSSGGFVWA CKNYDGDVQS 300
  301 DIVAQGYGSL GLMSSVLMCP DGKTIEAEAA HGTVTRHYRE HQKGNSTSTN PIASIFAWTR 360
  361 GLHHRGVLDN NEALKTFSLT LEKACIDTVE EGKMTKDLSI CIHGTKKGTE KGAYLITEDF 420
  421 LSAIDTKMAE LMRQD

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 135.0
Match: 1lwdA
Description: NADP-dependent isocitrate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
isocitrate dehydrogenase (NAD+) activity 5.9567768649084 bayes_pls_golite062009
isocitrate dehydrogenase activity 5.76817846591752 bayes_pls_golite062009
isocitrate dehydrogenase (NADP+) activity 3.47645456015586 bayes_pls_golite062009
oxidoreductase activity 2.74237430402883 bayes_pls_golite062009
catalytic activity 2.71251959637136 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 2.46799258909805 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2.38235863668553 bayes_pls_golite062009
transferase activity, transferring acyl groups 1.15484868227001 bayes_pls_golite062009
3-isopropylmalate dehydrogenase activity 0.848289435089509 bayes_pls_golite062009
binding 0.530580225668688 bayes_pls_golite062009
protein binding 0.074256700284446 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle