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View Structure Prediction Details

Protein: bli-4
Organism: Caenorhabditis elegans
Length: 730 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for bli-4.

Description E-value Query
Range
Subject
Range
gi|39595663, gi|... - gi|39595663|emb|CAE67165.1| Hypothetical protein CBG12593 [Caenorhabditis briggsae], gi|187029207|em...
gi|157747461 - gi|157747461|ref|XP_001668825.1| Hypothetical protein CBG12593 [Caenorhabditis briggsae AF16]
537.0 [0..1] [730..1]

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Predicted Domain #1
Region A:
Residues: [1-158]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRISIGRIAW QILAVLIAVA FTIEHDSICD ESIGACGEPI HTVIRLAKRD DELARRIAAD  60
   61 HDMHVKGDPF LDTHYFLYHS ETTRTRRHKR AIVERLDSHP AVEWVEEQRP KKRVKRDYIL 120
  121 LDNDVHHSNP FRRSVLNRDG TRRAQRQQPQ SPREIPSL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 9.045757
Match: 1t1eA
Description: High Resolution Crystal Structure of the Intact Pro-Kumamolisin, a Sedolisin Type Proteinase (previously called Kumamolysin or KSCP)
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [159-628]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFPDPLYKDQ WYLHGGAVGG YDMNVRQAWL QGYAGRNVSV SILDDGIQRD HPDLAANYDP  60
   61 LASTDINDHD DDPTPQNNGD NKHGTRCAGE VAALAGNNQC GVGVAFKAKI GGVRMLDGAV 120
  121 SDSVEAASLS LNQDHIDIYS ASWGPEDDGK TFDGPGPLAR EAFYRGIKNG RGGKGNIFVW 180
  181 ASGNGGSRQD SCSADGYTTS VYTLSISSAT YDNHRPWYLE ECPSSIATTY SSADFRQPAI 240
  241 VTVDVPGGCT DKHTGTSASA PLAAGIIALA LEANPELTWR DMQHLVLRTA NWKPLENNPG 300
  301 WSRNGVGRMV SNKFGYGLID GGALVNMAKT WKTVPEQHIC TYEYRLANPN PRPIVGRFQL 360
  361 NFTLDVNGCE SGTPVLYLEH VQVHATVRYL KRGDLKLTLF SPSGTRSVLL PPRPQDFNAN 420
  421 GFHKWPFLSV QQWGEDPRGT WLLMVESVTT NPAATGTFHD WTLLLYGTAD 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 93.522879
Match: 1p8jA
Description: Furin, C-terminal domain; Furin, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 4.77677490610016 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 4.40501322467328 bayes_pls_golite062009
serine hydrolase activity 4.30899317351154 bayes_pls_golite062009
serine-type peptidase activity 4.29545891350519 bayes_pls_golite062009
nerve growth factor binding 3.93556598541015 bayes_pls_golite062009
endopeptidase activity 3.83336601331518 bayes_pls_golite062009
serine-type endopeptidase activity 3.71508033196614 bayes_pls_golite062009
neurotrophin binding 2.36320382357038 bayes_pls_golite062009
hydrolase activity 2.05732080397524 bayes_pls_golite062009
eukaryotic cell surface binding 1.50287724152407 bayes_pls_golite062009
binding 1.08901362883653 bayes_pls_golite062009
catalytic activity 0.597535457699629 bayes_pls_golite062009
exopeptidase activity 0.42083764849682 bayes_pls_golite062009
protein binding 0.380935140681308 bayes_pls_golite062009
receptor binding 0.222369968782666 bayes_pls_golite062009
glycosaminoglycan binding 0.11649614154172 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [629-730]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PAQSGDPVYS ATPATSQGVL SRVHQLTSQG DEVVERIRNH WEVTLEESSH WNWEHAREHK  60
   61 SLQELNSSSR THSFLYSFTK FQPIFLIILV CIFDAIHRQF AV

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle