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View Structure Prediction Details

Protein: nhr-10
Organism: Caenorhabditis elegans
Length: 395 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for nhr-10.

Description E-value Query
Range
Subject
Range
gi|73967652 - gi|73967652|ref|XP_548399.2| PREDICTED: similar to Retinoic acid receptor RXR-alpha (Retinoid X rece...
283.0 [0..3] [391..49]

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Predicted Domain #1
Region A:
Residues: [1-113]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGGGPSSNN SSQPEEVCLV CSDISTGYHY GVPSCNGCKT FFRRTIMKNQ TFSCQFQGKC  60
   61 PVDKSIRCAC RHCRFEKCLQ VGMDRNAIQQ NRDPIGYTKR TRRYPPIKKV EAS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.30103
Match: 1lo1A
Description: Steroid hormone receptor Err2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.00967542385368 bayes_pls_golite062009
DNA binding 3.60745514727532 bayes_pls_golite062009
nucleic acid binding 3.47256374293954 bayes_pls_golite062009
binding 2.96409924710655 bayes_pls_golite062009
transcription activator activity 2.9532663930699 bayes_pls_golite062009
transcription factor activity 2.90769972671972 bayes_pls_golite062009
sequence-specific DNA binding 2.72967350701574 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 2.55186574506963 bayes_pls_golite062009
protein binding 2.44501340584871 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.40923942043513 bayes_pls_golite062009
steroid hormone receptor binding 2.19264900659739 bayes_pls_golite062009
androgen receptor binding 1.92232680714675 bayes_pls_golite062009
nuclear hormone receptor binding 1.91348392022358 bayes_pls_golite062009
transcription repressor activity 1.88834375049208 bayes_pls_golite062009
hormone receptor binding 1.8288193687002 bayes_pls_golite062009
ligand-dependent nuclear receptor activity 1.49515149729803 bayes_pls_golite062009
transcription factor binding 1.38523780690867 bayes_pls_golite062009
steroid hormone receptor activity 1.28090460550476 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.26452462867497 bayes_pls_golite062009
transporter activity 0.768214707487563 bayes_pls_golite062009
structural constituent of ribosome 0.644659911825478 bayes_pls_golite062009
transcription coactivator activity 0.61572149323953 bayes_pls_golite062009
transcription cofactor activity 0.58115018700114 bayes_pls_golite062009
transmembrane transporter activity 0.50876329665586 bayes_pls_golite062009
structural molecule activity 0.441960874303873 bayes_pls_golite062009
receptor activity 0.230063209127305 bayes_pls_golite062009
substrate-specific transporter activity 0.187612502757984 bayes_pls_golite062009
catalytic activity 0.101795606736461 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [114-395]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DECSPAMVSE NDRSEDNFLT LLSSTEQKCC ALRLAEYMPS RTLIEAVVSD CLLTDEVFMA  60
   61 EHAILSPRHR VTSLRFANQS DYHYWHERDW FVMIEWAKTL PVFQSLPFTD KLALLRHSAI 120
  121 TYPSLVHVFN SPDHGLDTIV FPDGAYFDRT PEPTRPLGFN KKKYQMLDQL LKPMRSMEID 180
  181 MTEFAAFKAI FFLNPDADDV DSNAKKTLSD GRSAITNALY RYMVKKKGAE DAGDRFGRLL 240
  241 LLGTVLATMA VEMKEAVLVA DFFDQIQFST FAKQLLFGIK TE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 44.69897
Match: 1xiuA
Description: Crystal structure of the agonist-bound ligand-binding domain of Biomphalaria glabrata RXR
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle