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View Structure Prediction Details

Protein: uch2
Organism: Schizosaccharomyces pombe
Length: 300 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for uch2.

Description E-value Query
Range
Subject
Range
gi|229577283, gi... - gi|5738242|gb|AAD50311.1|AF175903_1 ubiquitin C-terminal hydrolase UCH-L5 [Mus musculus], gi|2295772...
381.0 [0..2] [298..7]
gi|75773502, gi|... - gi|76253713|ref|NP_776906.2| ubiquitin carboxyl-terminal hydrolase L5 [Bos taurus], gi|75773502|gb|A...
381.0 [0..2] [298..7]
ENSMMUT000000318... - null, null
gi|15930175, gi|... - gi|55859543|emb|CAI10833.1| ubiquitin carboxyl-terminal hydrolase L5 [Homo sapiens], gi|30582419|gb|...
gi|61360019 - gi|61360019|gb|AAX41799.1| ubiquitin carboxyl-terminal hydrolase L5 [synthetic construct]
380.0 [0..2] [298..7]
gi|61369961, gi|... - gi|61369961|gb|AAX43419.1| ubiquitin carboxyl-terminal hydrolase L5 [synthetic construct], gi|305846...
380.0 [0..2] [298..7]
UCHL5_PIG - Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Sus scrofa GN=UCHL5 PE=2 SV=1
ENSOCUP00000014412 - pep:novel chromosome:oryCun2:16:77766040:77802483:1 gene:ENSOCUG00000016766 transcript:ENSOCUT000000...
379.0 [0..2] [298..7]
gi|74006052 - gi|74006052|ref|XP_536116.2| PREDICTED: similar to ubiquitin C-terminal hydrolase UCH37 [Canis famil...
378.0 [0..2] [298..7]

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Predicted Domain #1
Region A:
Residues: [1-220]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSWTTIESDA GVFTDLIENL GVKDVEVDEL YSLDVDSLRQ FPDIYGIIFL FKWNSKVDKP  60
   61 DGTMDYDSMD NIFFAKQVIN NACATQALLS VLLNHSDEID LGTTLSEFKD FSKTLPPELK 120
  121 GEALGNSEHI RCCHNSFARS DPFISEEVRA ATDEDEVYHF IAYTNINNVF YELDGLQAAP 180
  181 INHGSCTKEE FAEKAVSVIQ ARIANYDPAE IRFNLMVICK 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 81.522879
Match: 1uchA
Description: DEUBIQUITINATING ENZYME UCH-L3 (HUMAN) AT 1.8 ANGSTROM RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
peptidase activity 7.38847948226412 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 7.21002260103248 bayes_pls_golite062009
endopeptidase activity 6.57191549077589 bayes_pls_golite062009
cysteine-type peptidase activity 6.54685807643041 bayes_pls_golite062009
small conjugating protein-specific protease activity 6.39247995905454 bayes_pls_golite062009
ubiquitin-specific protease activity 5.91394445088241 bayes_pls_golite062009
hydrolase activity 4.82615927403291 bayes_pls_golite062009
ubiquitin thiolesterase activity 4.1832081096766 bayes_pls_golite062009
thiolester hydrolase activity 2.96735553959103 bayes_pls_golite062009
SUMO-specific protease activity 2.65263825059319 bayes_pls_golite062009
cysteine-type endopeptidase activity 1.95802900199539 bayes_pls_golite062009
binding 1.3276268995308 bayes_pls_golite062009
catalytic activity 1.05972260874031 bayes_pls_golite062009
protein binding 0.896934807256194 bayes_pls_golite062009
NEDD8-specific protease activity 0.687958315289315 bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds 0.495951820083869 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.467924587720185 bayes_pls_golite062009
nucleic acid binding 0.439226369799415 bayes_pls_golite062009
calcium-dependent cysteine-type endopeptidase activity 0.196538841514154 bayes_pls_golite062009
DNA binding 0.168761518285256 bayes_pls_golite062009
transferase activity 0.0852393573521809 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [221-300]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DKKASLLTRE DLTDEEKAAS IAVEDEKRLR WKRENQLRRH NFVGLFVELS KLLVKDRIDK  60
   61 NTWNSTLETA KAKYASQKRP 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.826 a.29.4 RecG, N-terminal domain


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle