YRC Public Data Repository - Protein Structure Prediction

Protein:	SPCC594.05c
Organism:	Schizosaccharomyces pombe
Length:	424 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPCC594.05c.

Description	E-value	Query Range	Subject Range
gi\|42553816, gi\|... - gi\|46136055\|ref\|XP_389719.1\| hypothetical protein FG09543.1 [Gibberella zeae PH-1], gi\|42553816\|gb\|E...	222.0	[0..22]	[408..2]
gi\|39971077, gi\|... - gi\|86196741\|gb\|EAQ71379.1\| hypothetical protein MGCH7_ch7g786 [Magnaporthe grisea 70-15], gi\|3997107...	218.0	[0..20]	[403..93]
gi\|38567239, gi\|... - gi\|38567239\|emb\|CAE76530.1\| conserved hypothetical protein [Neurospora crassa], gi\|32420341\|ref\|XP_3... gi\|85113780 - gi\|85113780\|ref\|XP_964584.1\| hypothetical protein NCU03178 [Neurospora crassa OR74A]	216.0	[0..13]	[407..34]
gi\|67524785, gi\|... - gi\|67524785\|ref\|XP_660454.1\| hypothetical protein AN2850.2 [Aspergillus nidulans FGSC A4], ref\|XP_40...	214.0	[0..7]	[408..309]
gi\|70999398, gi\|... - gi\|70999398\|ref\|XP_754418.1\| PHD transcription factor [Aspergillus fumigatus Af293], gi\|66852055\|gb\|... gi\|159127434 - gi\|159127434\|gb\|EDP52549.1\| PHD transcription factor, putative [Aspergillus fumigatus A1163]	198.0	[0..22]	[399..390]
gi\|68469461, gi\|... - gi\|68469461\|ref\|XP_721245.1\| potential COMPASS histone methyltransferase subunit Spp1p [Candida albi... orf19.10536, orf... - orf19.3018 CGDID:CAL0001351 Assembly 19, Contig19-10163 (184195, 182975) CDS, reverse complemented, ...	180.0	[0..70]	[392..16]
gi\|44981556 - gi\|44981556\|gb\|AAS51341.1\| ACR115Wp [Ashbya gossypii ATCC 10895] gi\|44981556, gi\|... - gi\|45185801\|ref\|NP_983517.1\| ACR115Wp [Ashbya gossypii ATCC 10895], gi\|44981556\|gb\|AAS51341.1\| ACR11...	176.0	[0..117]	[397..42]
gi\|190407821 - gi\|190407821\|gb\|EDV11086.1\| compass component spp1 [Saccharomyces cerevisiae RM11-1a] SPP1 - Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in tel... gi\|151942661 - gi\|151942661\|gb\|EDN61007.1\| COMPASS (complex proteins associated with Set1p) component [Saccharomyce... SPP1_YEAST - COMPASS component SPP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPP1 PE=1 SV=1	174.0	[0..117]	[398..21]
gi\|74137329 - gi\|74137329\|dbj\|BAE22029.1\| unnamed protein product [Mus musculus]	169.0	[0..116]	[294..3]

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Predicted Domain #1

Region A:
Residues: [1-115]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELTQENTEE NEKTHVESIV KFEDSNRGTI TDFHIETANN EEEKDANVIL NKSVKMEVEE  60
   61 VNGHVDSSST ETDIEMQVIQ QPTIPKKPPV SAHRRGPRKH RGNANSQLNL STADH

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [116-190]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QRPLYCICQK PDDGSWMLGC DGCEDWFHGT CVNIPESYND LTVQYFCPKC TEEGKGITTW  60
   61 KRKCRLRECS NPTRP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	14.09691
Match:	1wepA
Description:	Solution structure of PHD domain in PHF8
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
histone methyltransferase activity (H3-K4 specific)	4.92637371481036	bayes_pls_golite062009
methylated histone residue binding	4.19057851212315	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.36166850120952	bayes_pls_golite062009
histone acetyltransferase activity	3.20023500652896	bayes_pls_golite062009
lysine N-acetyltransferase activity	3.20023500652896	bayes_pls_golite062009
histone binding	3.01402804224903	bayes_pls_golite062009
binding	2.93415748500038	bayes_pls_golite062009
transcription regulator activity	2.10215685716306	bayes_pls_golite062009
DNA binding	2.03869452357604	bayes_pls_golite062009
histone methyltransferase activity	2.02130427551376	bayes_pls_golite062009
nucleic acid binding	1.96131140205947	bayes_pls_golite062009
protein deacetylase activity	1.85191754801422	bayes_pls_golite062009
histone deacetylase activity	1.81121374048292	bayes_pls_golite062009
nucleosome binding	1.69494047037058	bayes_pls_golite062009
protein methyltransferase activity	1.49667541832007	bayes_pls_golite062009
protein binding	1.42349040268084	bayes_pls_golite062009
	1.38236406424542	bayes_pls_golite062009
protein-lysine N-methyltransferase activity	1.3339105639569	bayes_pls_golite062009
histone-lysine N-methyltransferase activity	1.3339105639569	bayes_pls_golite062009
lysine N-methyltransferase activity	1.3339105639569	bayes_pls_golite062009
N-acetyltransferase activity	1.19037129579681	bayes_pls_golite062009
transcription factor activity	1.07783732946409	bayes_pls_golite062009
deacetylase activity	0.912057424750107	bayes_pls_golite062009
N-acyltransferase activity	0.873079221910902	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.655033722565177	bayes_pls_golite062009
kinase activity	0.596989785523293	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.465950484314184	bayes_pls_golite062009
transcription activator activity	0.412877524046899	bayes_pls_golite062009
protein kinase activity	0.405766438875014	bayes_pls_golite062009
acetyltransferase activity	0.39905022319963	bayes_pls_golite062009
cytoskeletal protein binding	0.327424740985033	bayes_pls_golite062009
transferase activity	0.245705939593188	bayes_pls_golite062009
transcription repressor activity	0.21967019109013	bayes_pls_golite062009
N-methyltransferase activity	0.137650352572163	bayes_pls_golite062009
	0.0927457062201698	bayes_pls_golite062009
histone acetyl-lysine binding	0.0410393640547611	bayes_pls_golite062009
chromatin binding	0.00998492293684938	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [191-299]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSNYCSDKHG VDFFREKVKL STVEPSAIKN LVLFAKKREE FQNLGTVGPT LPSQVPPEVV  60
   61 YNFEIEEANR LNAEIVQLNK EKEVASNKKI FLQLIKDSSR RAVLAYKER

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [300-424]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EGIKKDLCGF DSRLLFNQQQ MNELWEKVSN GAPLSLDMSI DPSPESTCFT EKRRCAKHTS  60
   61 WQVIFTEDFE LQESNILQKL NMKQTAKDVM LEHQKQRCLP GIQYDGYARF CHEQLSPEKM 120
  121 ANLLK

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: